Abstract:
BACKGROUND:The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course. METHODS:The expression of CCL2, CCL5, TNFα and IL-1β was determined by immunohistochemistry in patients diagnosed with: (1) Benign breast disorders (=healthy individuals); (2) Ductal Carcinoma In Situ (DCIS); (3) Invasive Ducal Carcinoma without relapse (IDC-no-relapse); (4) IDC-with-relapse. Based on the results obtained, breast tumor cells were stimulated by the inflammatory cytokines, and epithelial-to-mesenchymal transition (EMT) was determined by flow cytometry, confocal analyses and adhesion, migration and invasion experiments. RESULTS:CCL2, CCL5, TNFα and IL-1β were expressed at very low incidence in normal breast epithelial cells, but their incidence was significantly elevated in tumor cells of the three groups of cancer patients. Significant associations were found between CCL2 & CCL5 and TNFα & IL-1β in the tumor cells in DCIS and IDC-no-relapse patients. In the IDC-with-relapse group, the expression of CCL2 & CCL5 was accompanied by further elevated incidence of TNFα & IL-1β expression. These results suggest progression-related roles for TNFα and IL-1β in breast cancer, as indeed indicated by the following: (1) Tumors of the IDC-with-relapse group had significantly higher persistence of TNFα and IL-1β compared to tumors of DCIS or IDC-no-relapse; (2) Continuous stimulation of the tumor cells by TNFα (and to some extent IL-1β) has led to EMT in the tumor cells; (3) Combined analyses with relevant clinical parameters suggested that IL-1β acts jointly with other pro-malignancy factors to promote disease relapse. CONCLUSIONS:Our findings suggest that the coordinated expression of CCL2 & CCL5 and TNFα & IL-1β may be important for disease course, and that TNFα & IL-1β may promote disease relapse. Further in vitro and in vivo studies are needed for determination of the joint powers of the four factors in breast cancer, as well as analyses of their combined targeting in breast cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Soria G,Ofri-Shahak M,Haas I,Yaal-Hahoshen N,Leider-Trejo L,Leibovich-Rivkin T,Weitzenfeld P,Meshel T,Shabtai E,Gutman M,Ben-Baruch Adoi
10.1186/1471-2407-11-130subject
Has Abstractpub_date
2011-04-12 00:00:00pages
130issn
1471-2407pii
1471-2407-11-130journal_volume
11pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-383
更新日期:2014-05-29 00:00:00
abstract:BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-883
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06738-z
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3485-0
更新日期:2017-07-18 00:00:00
abstract:BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2834-8
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3842-z
更新日期:2017-12-05 00:00:00
abstract:BACKGROUND:Clinical characterization of bladder carcinomas is still inadequate using the standard clinico-pathological prognostic markers. We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC). METHODS:nm23-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-32
更新日期:2009-01-26 00:00:00
abstract:BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6583-3
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5641-1
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-618
更新日期:2013-12-31 00:00:00
abstract:BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1390-y
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3803-6
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2840-x
更新日期:2016-10-22 00:00:00
abstract:BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1784-x
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:To date, no single colorectal cancer (CRC) screening strategy has been determined to be applicable worldwide. In China, a CRC screening protocol that combines double fecal immunochemical tests (FITs) and a high-risk factor questionnaire (HRFQ) as the first stage of screening and colonoscopy as the second sta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5191-y
更新日期:2019-01-10 00:00:00
abstract:BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07515-8
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-promoted colon cancer. Resveratrol (trans-3, 4', 5,-trihydroxystilbene), a stilbenoid found in the s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-238
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-193
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved for TNBC and cytotoxic agents remain the mainstay of treatment. Ixazomib is a selective and reversib...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4979-0
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earl...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3175-y
更新日期:2017-03-11 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4637-6
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL is highly personalized and complex therapy. It requests substantial upfront investments from the hosp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4788-5
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced pancreatic cancer (LAPC). METHODS:In this retrospectiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-199
更新日期:2012-05-29 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6538-8
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-143
更新日期:2007-07-30 00:00:00
abstract:BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07751-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-315
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-164
更新日期:2006-06-23 00:00:00
abstract:BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-235
更新日期:2006-10-03 00:00:00