当前位置： SCI文献检索 > BMC CANCER期刊下所有文献 > Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer.

Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer.

Abstract：

BACKGROUND:Although preoperative radiotherapy (RT) is widely used as the initial treatment for locally advanced rectal cancer (RC) in the neoadjuvant setting, factors determining clinical response have not been adequately defined. In order to find other factors possibly related with radiosensitivity, we evaluated the relationships between circulating blood cell counts and RT effects. METHODS:In 179 cases with advanced RC, we retrospectively examined hemoglobin (Hb) levels and counts of white blood cells (WBC), platelets and WBC subsets before and after RT and investigated their associations with the complete response (CR) rate together with other clinicopathological factors. RESULTS:The ratio of lymphocytes in WBC taken before RT was significantly greater in 15 CR cases as compared with those in non-CR cases. Patients with high lymphocyte percentages (25.7%) showed better outcome than the counterparts. Conversely, the ratio of neutrophiles was reduced in CR cases. The lymphocyte ratio showed an independent association with CR with multivariate analysis, and tended to be maintained at relatively high levels in CR cases. CONCLUSIONS:In RC patients, peripheral blood lymphocytes have a significant impact on the CR rate in response to RT. Lymphocyte-mediated immune reactions are supposed to have positive roles on clinical response in radiotherapy for RC.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Kitayama J,Yasuda K,Kawai K,Sunami E,Nagawa H

doi

10.1186/1471-2407-11-64

subject

Has Abstract

pub_date

2011-02-10 00:00:00

pages

64

issn

1471-2407

pii

1471-2407-11-64

journal_volume

11

pub_type

杂志文章

相关文献

BMC CANCER文献大全