听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览BRAIN RESEARCH期刊下所有文献
  • Anxiety in Parkinson's disease: Abnormal resting activity and connectivity.

    abstract::Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147235

    authors: Criaud M,Kim JH,Zurowski M,Lobaugh N,Chavez S,Houle S,Strafella AP

    更新日期:2021-02-15 00:00:00

  • Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.

    abstract::The contribution of glutamatergic transmission to generation of initial convulsive seizures (CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), affects the onset and progression of initial CS by cholinergic stimulus in juvenile rats. Male rats (24 d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147253

    authors: Pawlik MJ,Obara-Michlewska M,Popek MP,Czarnecka AM,Czuczwar SJ,Łuszczki J,Kołodziej M,Acewicz A,Wierzba-Bobrowicz T,Albrecht J

    更新日期:2021-02-15 00:00:00

  • Structural and functional brain abnormalities in postherpetic neuralgia: A systematic review of neuroimaging studies.

    abstract::In recent decades, an increasing number of neuroimaging studies utilizing magnetic resonance imaging (MRI) have explored the differential effects of postherpetic neuralgia (PHN) on brain structure and function. We systematically reviewed and integrated the findings from relevant neuroimaging studies in PHN patients. A...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147219

    authors: Tang Y,Wang M,Zheng T,Xiao Y,Wang S,Han F,Chen G

    更新日期:2021-02-01 00:00:00

  • Distribution of growth hormone-responsive cells in the brain of rats and mice.

    abstract::A growth hormone (GH) injection is able to induce the phosphorylated form of the signal transducer and activator of transcription 5 (pSTAT5) in a large number of cells throughout the mouse brain. The present study had the objective to map the distribution of GH-responsive cells in the brain of rats that received an in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147189

    authors: Wasinski F,Klein MO,Bittencourt JC,Metzger M,Donato J Jr

    更新日期:2021-01-15 00:00:00

  • Effect of acute mitochondrial dysfunction on hyperexcitable network activity in rat hippocampus in vitro.

    abstract::Metabolic stress imposed by epileptic seizures can result in mitochondrial dysfunction, believed to act as positive feedback on epileptogenesis and seizure susceptibility. As the mechanism behind this positive feedback is unclear, the aim of the present study was to investigate the causal link between acute mitochondr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147193

    authors: Andreasen M,Nedergaard S

    更新日期:2021-01-15 00:00:00

  • Social buffering of cortisol release and tympanic temperature asymmetries during novelty and isolation stress in marmoset monkeys.

    abstract::Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147198

    authors: Pereira LC,Barros M

    更新日期:2021-01-15 00:00:00

  • Salience, emotion, and attention: the neural networks underlying tinnitus distress revealed using music and rest.

    abstract::In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2021.147277

    authors: Shahsavarani S,Schmidt SA,Khan RA,Tai Y,Husain FT

    更新日期:2021-01-07 00:00:00

  • Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry.

    abstract::The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147237

    authors: Alonso-Matielo H,Gonçalves ES,Campos M,Oliveira VRS,Toniolo EF,Alves AS,Lebrun I,de Andrade DC,Teixeira MJ,Britto LRG,Hamani C,Dale CS

    更新日期:2021-01-02 00:00:00

  • Dexmedetomidine inhibits apoptosis of astrocytes induced by oxygen-glucose deprivation via targeting JAK/STAT3 signal pathway.

    abstract:OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147141

    authors: Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

    更新日期:2021-01-01 00:00:00

  • Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.

    abstract::Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147153

    authors: Kanda H,Kobayashi K,Yamanaka H,Okubo M,Dai Y,Noguchi K

    更新日期:2021-01-01 00:00:00

  • Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.

    abstract::Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147127

    authors: Sanfilippo C,Castrogiovanni P,Imbesi R,Nunnari G,Di Rosa M

    更新日期:2020-12-15 00:00:00

  • Cross-talk pattern between GABAA- and glycine-receptors in CNS neurons is shaped by their relative expression levels.

    abstract::GABAA receptors (GABAARs) and glycine receptors (GlyRs) are two principal inhibitory chloride ion channels in the central nervous system. The two receptors do not function independently but cross-talk to each other, i.e., the activation of one receptor would inhibit the other. This cross-talk is present in different p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147071

    authors: Tang ZQ,Lu YG,Huang YN,Chen L

    更新日期:2020-12-01 00:00:00

  • Computational capacity of pyramidal neurons in the cerebral cortex.

    abstract::The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147069

    authors: Georgiev DD,Kolev SK,Cohen E,Glazebrook JF

    更新日期:2020-12-01 00:00:00

  • Vagus nerve stimulation promotes cortical reorganization and reduces task-dependent calorie intake in male and female rats.

    abstract::Numerous preclinical studies demonstrate that vagus nerve stimulation (VNS) paired with motor rehabilitation improves functional recovery after neural injuries such as stroke, traumatic brain injury, and spinal cord injury, in part by driving neural plasticity within the motor cortex. To date, these studies have been ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147099

    authors: Tseng CT,Brougher J,Gaulding SJ,Hassan BS,Thorn CA

    更新日期:2020-12-01 00:00:00

  • Depletion of C1 neurons attenuates the salt-induced hypertension in unanesthetized rats.

    abstract::High salt intake is able to evoke neuroendocrine and autonomic responses that include vasopressin release and sympathoexcitation resulting in increasing in the arterial blood pressure (BP). The C1 neurons are a specific population of catecholaminergic neurons located in the RVLM region and they control BP under homeos...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147107

    authors: Ribeiro N,Martins Sá RW,Antunes VR

    更新日期:2020-12-01 00:00:00

  • Changes in the metabolic profiles of the serum and putamen in Parkinson's disease patients - In vitro and in vivo NMR spectroscopy studies.

    abstract::The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147118

    authors: Toczylowska B,Zieminska E,Michałowska M,Chalimoniuk M,Fiszer U

    更新日期:2020-12-01 00:00:00

  • Theta and alpha oscillatory responses differentiate between six-to seven-year-old children and adults during successful visual and auditory memory encoding.

    abstract::The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147042

    authors: Güntekin B,Uzunlar H,Çalışoğlu P,Eroğlu-Ada F,Yıldırım E,Aktürk T,Atay E,Ceran Ö

    更新日期:2020-11-15 00:00:00

  • An integrative model of network activity during episodic memory retrieval and a meta-analysis of fMRI studies on source memory retrieval.

    abstract::Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147049

    authors: Kim H

    更新日期:2020-11-15 00:00:00

  • Spatiotemporal brain signal associated with high and low levels of proactive motor response inhibition.

    abstract::Proactive motor response inhibition is used to strategically restrain actions in preparation for stopping. In this study, we first examined the event related potential (ERP) elicited by low and high level of proactive response inhibition, as assessed by the stop-signal task. Corroborating previous studies, we found an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147064

    authors: Brevers D,Cheron G,Dahman T,Petieau M,Palmero-Soler E,Foucart J,Verbanck P,Cebolla AM

    更新日期:2020-11-15 00:00:00

  • Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum.

    abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146968

    authors: Almeida LEF,Wang L,Kamimura S,Zerfas PM,Smith ML,Neto OLA,Vale T,Quezado MM,Horkayne-Szakaly I,Wakim P,Quezado ZMN

    更新日期:2020-11-01 00:00:00

  • Dynamic changes of brain networks during feedback-related processing of reinforcement learning in schizophrenia.

    abstract::Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146979

    authors: Zhao Z,Wang C,Yuan Q,Zhao J,Ren Q,Xu Y,Li J,Yu Y

    更新日期:2020-11-01 00:00:00

  • Effects of Toxoplasma gondii infection on the function and integrity of human cerebrovascular endothelial cells and the influence of verapamil treatment in vitro.

    abstract::Toxoplasma gondii can cause parasitic encephalitis, a life-threatening infection that predominately occurs in immunocompromised individuals. T. gondii has the ability to invade the brain, but the mechanisms by which this parasite crosses the blood-brain-barrier (BBB) remain incompletely understood. The present study r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147002

    authors: Harun MSR,Marsh V,Elsaied NA,Webb KF,Elsheikha HM

    更新日期:2020-11-01 00:00:00

  • Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats.

    abstract::Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A li...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147007

    authors: Marques MS,Cordeiro MF,Marinho MAG,Vian CO,Vaz GR,Alves BS,Jardim RD,Hort MA,Dora CL,Horn AP

    更新日期:2020-11-01 00:00:00

  • Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice.

    abstract::Olfactory bulbectomy (OBX) in rodents induces neurochemical and behavioral changes similar to those observed in individuals with depressive disorders. Our previous study suggested that OBX alters dopaminergic function in the striatum of mice; however, the effects on dopaminergic function in the hypothalamus is unknown...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147015

    authors: Takahashi K,Nakagawasai O,Nakajima T,Okubo M,Nishimura Y,Sakuma W,Yamagata R,Nemoto W,Miyagawa K,Kurokawa K,Mochida-Saito A,Tsuji M,Takeda H,Tadano T,Tan-No K

    更新日期:2020-11-01 00:00:00

  • Pubertal stress decreases sexual motivation and supresses the relation between cerebral theta rhythms and testosterone levels in adult male rats.

    abstract::This study evaluated the effect of stress during puberty on sexual motivation and the correlation between serum testosterone levels (T) and the absolute power of the theta electroencephalographic rhythms, recorded in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) of adult male rats. Thirty males of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146937

    authors: Hernández-Arteaga E,Hernández-González M,Bonilla-Jaime H,Guevara MA,Ågmo A

    更新日期:2020-10-15 00:00:00

  • MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification.

    abstract::Seizure is a common acute and severe disease in infants and children. Recurrent seizures or persistent seizures may cause irreversible brain damage. Mitogen activated protein kinase (MAPK) signaling pathway is associated with an inflammatory response, however it's involvement in the pathological process of seizures is...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146932

    authors: Hu QP,Huang XY,Peng F,Yang H,Wu C

    更新日期:2020-10-15 00:00:00

  • Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.

    abstract::The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146879

    authors: Khan M,Kumar P,Qiao F,Islam SMT,Singh AK,Won JS,Feng W,Singh I

    更新日期:2020-08-15 00:00:00

  • One-week phonemic training rebuilds the memory traces of merged phonemes in merged speakers.

    abstract::The phonemic merger is a unique phenomenon which is referred to as acoustically very different phonemes are recognized as the same phoneme. In our previous study, we demonstrated that the merged speakers had lost the ability to discriminate the merged phonemes pre-attentively, as revealed by their failure in mismatch ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146848

    authors: Tang M,Huang ZL,Zhong F,Xiang JL,Wang XD

    更新日期:2020-08-01 00:00:00

  • Evaluating the amygdala network induced by neurofeedback training for emotion regulation using hierarchical clustering.

    abstract:BACKGROUND:Previous studies have shown that regulating the target region by real-time fMRI-based neurofeedback training can influence the activation of other regions and the functional connectivity between them. However, it is not clear whether the training effect of neurofeedback, especially in emotion regulation, is ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146853

    authors: Liu N,Yao L,Zhao X

    更新日期:2020-08-01 00:00:00

  • Intra-axonal mechanisms driving axon regeneration.

    abstract::Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2020.146864

    authors: Smith TP,Sahoo PK,Kar AN,Twiss JL

    更新日期:2020-08-01 00:00:00

  • Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols.

    abstract::The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146798

    authors: Dumont U,Sanchez S,Olivier B,Chateil JF,Deffieux D,Quideau S,Pellerin L,Beauvieux MC,Bouzier-Sore AK,Roumes H

    更新日期:2020-07-01 00:00:00

  • Apathy in frontotemporal dementia is related to medial prefrontal atrophy and is independent of executive dysfunction.

    abstract:INTRODUCTION:Apathy is the most common neuropsychiatric syndrome in behavioral variant frontotemporal dementia (bvFTD), and encompasses cognitive, behavioral and affective symptoms. The neural basis of apathy in bvFTD is not completely understood. Previous neuroimaging studies have poorly considered executive impairmen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146799

    authors: Gonçalves SAB,Caramelli P,Mariano LI,Guimarães HC,Gambogi LB,Resende EPF,Teixeira AL,de Souza LC

    更新日期:2020-06-15 00:00:00

  • Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke.

    abstract::The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146778

    authors: Kaiser EE,Waters ES,Fagan MM,Scheulin KM,Platt SR,Jeon JH,Fang X,Kinder HA,Shin SK,Duberstein KJ,Park HJ,West FD

    更新日期:2020-06-01 00:00:00

  • Complex network analysis of MCI-AD EEG signals under cognitive and resting state.

    abstract:OBJECTIVE:The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions. METHOD:EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146743

    authors: Das S,Puthankattil SD

    更新日期:2020-05-15 00:00:00

  • Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.

    abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146760

    authors: Jung S,Ballheimer YE,Brackmann F,Zoglauer D,Geppert CI,Hartmann A,Trollmann R

    更新日期:2020-05-15 00:00:00

  • Male mice placed on a ketogenic diet from postnatal day (P) 21 through adulthood have reduced growth, are hypoactive, show increased freezing in a conditioned fear paradigm, and have spatial learning deficits.

    abstract::The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146697

    authors: Miles KN,Skelton MR

    更新日期:2020-05-01 00:00:00

  • Glycan changes in the olfactory mucosa of rats with experimental autoimmune encephalomyelitis.

    abstract::Glycans are components of glycoconjugates and function in odorant recognition and cell signaling in the olfactory mucosa. However, little is known about glycan expression in the olfactory mucosa in the presence of neuroinflammatory disorders, which can influence olfaction. We evaluated the changes in glycan in the olf...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146649

    authors: Park C,Kim J,Ahn M,Choi Y,Shin T

    更新日期:2020-04-01 00:00:00

  • Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord.

    abstract::To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146674

    authors: Salehi S,Kashfi K,Manaheji H,Haghparast A

    更新日期:2020-04-01 00:00:00

  • Ethical issues related to brain organoid research.

    abstract::This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2020.146653

    authors: Hyun I,Scharf-Deering JC,Lunshof JE

    更新日期:2020-04-01 00:00:00

  • Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area.

    abstract::Glucose inhibits ∼60% of lateral hypothalamic (LH) orexin neurons. Fasting increases the activation of LH orexin glucose-inhibited (GI) neurons in low glucose. Increases in spontaneous glutamate excitatory postsynaptic currents (sEPSCs) onto putative VTA DA neurons in low glucose are orexin dependent (Sheng et al., 20...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.05.025

    authors: Teegala SB,Sheng Z,Dalal MS,Hirschberg PR,Beck KD,Routh VH

    更新日期:2020-03-15 00:00:00

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