Abstract：
:In recent decades, an increasing number of neuroimaging studies utilizing magnetic resonance imaging (MRI) have explored the differential effects of postherpetic neuralgia (PHN) on brain structure and function. We systematically reviewed and integrated the findings from relevant neuroimaging studies in PHN patients. A total of 15 studies with 16 datasets were ultimately included in the present study, which were categorized by the different neuroimaging modalities. The results revealed that PHN was closely associated with structural/microstructural and functional abnormalities of the brain mainly located in the 'pain matrix', including the thalamus, insula, parahippocampus, amygdala, dorsolateral prefrontal cortex, precentral gyrus and inferior parietal lobe, as well as other regions, such as the precuneus, lentiform nucleus and brainstem. Furthermore, a disruption of multiple networks, including the default-mode network, salience network and limbic system, may contribute to the neurophysiological mechanisms underlying PHN. The findings indicate that the cerebral abnormalities of PHN were not restricted to the pain matrix but extended to other regions, profoundly affecting the regulation and moderation of pain processing in PHN. Future prospective and longitudinal neuroimaging studies with larger samples will elucidate the progressive trajectory of neural changes in the pathophysiological process of PHN.
journal_name
Brain Resjournal_title
Brain researchauthors
Tang Y,Wang M,Zheng T,Xiao Y,Wang S,Han F,Chen Gdoi
10.1016/j.brainres.2020.147219subject
Has Abstractpub_date
2021-02-01 00:00:00pages
147219eissn
0006-8993issn
1872-6240pii
S0006-8993(20)30577-1journal_volume
1752pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the regional density of binding to 5-HT receptors and transporters and the l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02055-7
更新日期：1999-11-13 00:00:00
abstract：:Synaptosomes assemble an equatorial coil of microtubules during incubation at 37 degrees C. Stimulation of synaptosomes by veratridine or A23187 for 5 min results in disassembly of the microtubules. The role of microtubule disassembly in neurotransmitter release was investigated using the microtubule-stabilizing drug ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91192-7
更新日期：1983-11-28 00:00:00
abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02793-1
更新日期：2000-10-13 00:00:00
abstract：:Prolonged exposure of opioid receptors to agonists leads to their regulation by the classical process of clathrin-dependent internalization, followed by their intracellular degradation (down regulation). We have previously shown that the opioid agonist etorphine induced an additional process of down regulation of mu-o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.040
更新日期：2011-04-22 00:00:00
abstract：:Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.009
更新日期：2012-10-30 00:00:00
abstract：:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03178-5
更新日期：2002-10-04 00:00:00
abstract：:The purpose of the present investigation was to record electrophysiological responses from single fibers in the hamster superior laryngeal nerve (SLN) that were responsive to chemical stimulation of the larynx. Twenty chemical solutions, commonly used in studies of mammalian gustatory physiology, were applied to taste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91541-7
更新日期：1988-05-31 00:00:00
abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00659-3
更新日期：1998-08-24 00:00:00
abstract：:Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00076-6
更新日期：1998-03-30 00:00:00
abstract：:Fos expression in vestibular brainstem and cerebellar regions was evaluated during vestibular adaptation in the Mongolian gerbil. In addition, vestibular adaptation was evaluated in both normal and compensated animals, as vestibular compensation reorganizes the vestibular pathway constraining adaptive processes. Behav...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.029
更新日期：2005-07-19 00:00:00
abstract：BACKGROUND:Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.012
更新日期：2016-03-01 00:00:00
abstract：:Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91300-h
更新日期：1993-02-12 00:00:00
abstract：:Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.076
更新日期：2007-02-16 00:00:00
abstract：:It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90234-m
更新日期：1991-07-05 00:00:00
abstract：:High cell density, with attendant aggregation, selectively increases expression of substance P (SP) and choline acetyltransferase (ChAT) in virtually pure neonatal sympathetic neuronal cultures. To investigate the specific role of cell contact in selective transmitter expression, SP content and ChAT activity were exam...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80202-5
更新日期：1986-12-01 00:00:00
abstract：:The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91614-x
更新日期：1993-08-13 00:00:00
abstract：:Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.105
更新日期：2006-06-06 00:00:00
abstract：:The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specificati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.058
更新日期：2008-09-04 00:00:00
abstract：:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02331-3
更新日期：2000-07-28 00:00:00
abstract：:Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90987-8
更新日期：1982-12-02 00:00:00
abstract：:We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02920-6
更新日期：2000-11-10 00:00:00
abstract：:Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.019
更新日期：2015-12-10 00:00:00
abstract：:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91215-7
更新日期：1994-02-21 00:00:00
abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02210-7
更新日期：2001-04-20 00:00:00
abstract：:The effects of sodium valproate on extracellularly recorded spontaneous neuronal activity and its interaction with GABA-induced inhibition were assessed in the rat medial basal hypothalamus both in situ and in explant culture. In situ, valproate enhanced the spontaneous rate in 14 of 20 neurons sampled, 6 neurons were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90288-2
更新日期：1981-08-24 00:00:00
abstract：:The peroxidase-antiperoxidase (PAP) immunohistochemical technique was used to identify neurons in the basolateral amygdaloid nucleus (BL) that contain vasoactive intestinal polypeptide (VIP), somatostatin (SOM) or cholecystokinin (CCK). Examination of immunostained neurons demonstrated that most, if not all, of these ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90266-5
更新日期：1985-07-08 00:00:00
abstract：:Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02918-3
更新日期：2001-11-09 00:00:00
abstract：:alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91215-e
更新日期：1993-04-30 00:00:00
abstract：:We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.025
更新日期：2009-01-16 00:00:00
abstract：:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.04.045
更新日期：2010-06-25 00:00:00
