Abstract：
:Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with PD were recruited for this study, 20 with higher anxiety scores and 19 with lower anxiety scores. They all underwent a resting-state fMRI scan, while they were on medication. The amplitude of low-frequency fluctuation (ALFF) and seed-based connectivity were investigated to reveal the changes of the spontaneous activity and the interaction among different related regions. The results provided evidence that anxiety in Parkinson's disease is associated with the over-activation of the amygdala and impaired inter-relationship of regions involved in behavior (i.e. medial prefrontal cortex, insula) and motor control (i.e. basal ganglia).
journal_name
Brain Resjournal_title
Brain researchauthors
Criaud M,Kim JH,Zurowski M,Lobaugh N,Chavez S,Houle S,Strafella APdoi
10.1016/j.brainres.2020.147235subject
Has Abstractpub_date
2021-02-15 00:00:00pages
147235eissn
0006-8993issn
1872-6240pii
S0006-8993(20)30593-Xjournal_volume
1753pub_type
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