Changes in the metabolic profiles of the serum and putamen in Parkinson's disease patients - In vitro and in vivo NMR spectroscopy studies.

abstract：:DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form of DJ-1, was observed in PD patients. DJ-1-binding compound B, which ...

journal_title：Brain research

authors： Niki T,Endo J,Takahashi-Niki K,Yasuda T,Okamoto A,Saito Y,Ariga H,Iguchi-Ariga SMM

更新日期：2020-02-15 00:00:00

abstract：:Prior studies indicate that, in tests of recognition memory, ERPs elicited by correctly recognized test items differ according to whether the items were encoded in an emotionally arousing or an emotionally neutral study context. These prior studies employed only a relatively brief (ca. 10 min) retention interval, howe...

journal_title：Brain research

authors： Jaeger A,Johnson JD,Corona M,Rugg MD

更新日期：2009-05-07 00:00:00

abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...

journal_title：Brain research

authors： Holinger DP,Bellugi U,Mills DL,Korenberg JR,Reiss AL,Sherman GF,Galaburda AM

更新日期：2005-03-10 00:00:00

abstract：:Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...

journal_title：Brain research

authors： Mazei MS,Pluto CP,Kirkbride B,Pehek EA

更新日期：2002-05-17 00:00:00

abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...

journal_title：Brain research

authors： She Y,Xu J,Duan Y,Su N,Sun Y,Cao X,Lao L,Zhang R,Xu S

更新日期：2015-12-10 00:00:00

abstract：:Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...

journal_title：Brain research

authors： Kalivas PW,Nemeroff CB,Miller JS,Prange AJ Jr

更新日期：1985-02-11 00:00:00

abstract：:Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, and exerts CB1-mediated central antinociception in the mouse tail-flick assay. The aim of the present study was to further investigate the analgesic properties of supraspinal mouse VD-...

journal_title：Brain research

authors： Zheng T,Zhang R,Zhang T,Zhang MN,Xu B,Song JJ,Li N,Tang HH,Wang P,Wang R,Fang Q

更新日期：2018-02-01 00:00:00

abstract：:The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...

journal_title：Brain research

authors： Uyama O,Nagatsuka K,Fukunaga R,Kusunoki M,Takano T,Yoneda S,Kimura K,Abe H

更新日期：1983-01-24 00:00:00

abstract：:Stroke-prone spontaneously hypertensive rats (SHRSP) are a well-characterized, genetic model for stroke. We showed earlier that the structure and function of the tight junctions in SHRSP blood-brain barrier endothelial cells is disturbed prior to stroke. To investigate the molecular events leading to endothelial dysfu...

journal_title：Brain research

authors： Kirsch T,Wellner M,Luft FC,Haller H,Lippoldt A

更新日期：2001-08-10 00:00:00

abstract：:Peripheral nerve injury induces changes in gene expressions of a variety of neuroactive substances in cell somata, which may have roles in the adaptive response to the injury, neuronal survival, growth and regeneration. In this study, we designed a rat model of ischemic peripheral facial paralysis with a selective emb...

journal_title：Brain research

authors： Mohri D,Satomi F,Kondo E,Fukuoka T,Sakagami M,Noguchi K

更新日期：2001-03-02 00:00:00

abstract：:Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...

journal_title：Brain research

authors： Alzheimer C,Röhrenbeck J,ten Bruggencate G

更新日期：1991-03-08 00:00:00

abstract：:Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...

journal_title：Brain research

authors： Craig AD

更新日期：1992-07-03 00:00:00

abstract：:Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...

journal_title：Brain research

authors： Maciag D,Coppinger D,Paul IA

更新日期：2006-12-13 00:00:00

abstract：:The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions rela...

journal_title：Brain research

authors： Abraham A,Beudt S,Ott DV,Yves von Cramon D

更新日期：2012-10-30 00:00:00

abstract：:In vivo release of labeled serotonin ([3H]5-HT) from the parietal cortex was investigated by cortical cup technique and electrical stimulation of midbrain raphe in rats anesthetized with pentobarbital sodium. The spontaneous efflux of tritium from the parietal cortex preload with [3H]5-HT followed a multiphasic expone...

journal_title：Brain research

authors： Fujiwara H,Uemoto M,Tanaka C

更新日期：1981-07-20 00:00:00

abstract：:The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

journal_title：Brain research

authors： Rasmussen K,Strecker RE,Jacobs BL

更新日期：1986-03-26 00:00:00

abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...

journal_title：Brain research

authors： Neal AP,Stansfield KH,Guilarte TR

更新日期：2012-02-23 00:00:00

abstract：:The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the...

journal_title：Brain research

authors： Arai H,Emson PC,Mountjoy CQ,Carassco LH,Heizmann CW

更新日期：1987-08-18 00:00:00

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP. L-thr...

journal_title：Brain research

authors： Sakai N,Sasa M,Ishihara K,Komure O,Tanaka C,Takaori S

更新日期：1991-12-20 00:00:00

abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is synthesized by discrete populations of hypothalamic neurons which project in different brain regions including the cerebral cortex, hippocampus and amygdala nuclei. The purpose of the present study was to identify the alpha-MSH-immunoreactive species...

journal_title：Brain research

authors： Bunel DT,Delbende C,Blasquez C,Jegou S,Vaudry H

更新日期：1990-04-16 00:00:00

abstract：:Correlative light and electron microscopic immunohistochemical methods were adapted for a descriptive analysis of the normal time course and pattern of expression and intraneuronal localization of the enzyme glutamic acid decarboxylase (GAD) in the neostriatum (Ns) of fetal, postnatal and adult cats. The differentiati...

journal_title：Brain research

authors： Fisher RS,Levine MS,Adinolfi AM,Hull CD,Buchwald NA

更新日期：1987-06-01 00:00:00

abstract：:Mild NMDA receptor activation is correlated with neuroprotection in models of cerebral ischemia. Neuroprotection with NMDA manifests as a form of ischemic tolerance and involves the induction of cellular stress systems sensitive to disturbances in cellular calcium homeostasis. Unilateral micro-injection of 10, 160 and...

journal_title：Brain research

authors： Saleh MC,Connell BJ,Saleh TM

更新日期：2009-01-09 00:00:00

abstract：:Opiates modulate pain perception at a number of different levels within the central nervous system and the importance of synergistic spinal and supraspinal influences have been well documented. In the present study we demonstrate synergistic interactions between the periaqueductal gray and locus coeruleus. Administere...

journal_title：Brain research

authors： Bodnar R,Paul D,Pasternak GW

更新日期：1991-09-06 00:00:00

abstract：:The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...

journal_title：Brain research

authors： Cruickshank JW,Brudzynski SM,McLachlan RS

更新日期：1994-04-18 00:00:00

abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...

journal_title：Brain research

authors： Coelho JE,de Mendonça A,Ribeiro JA

更新日期：2000-06-30 00:00:00

abstract：:beta-Amyloid is the primary protein component of neuritic plaques, which are degenerative foci in brains of patients with Alzheimer's disease (AD). The effects of this naturally occurring beta-amyloid on the cells of the central nervous system have not been completely understood. beta-Amyloid increases the vulnerabili...

journal_title：Brain research

authors： Parpura-Gill A,Beitz D,Uemura E

更新日期：1997-04-18 00:00:00

abstract：:Long-term potentiation (LTP) has a memory-like consolidation period during which it becomes progressively stabilized. However, it is unknown how the consolidation is achieved. The present study demonstrates that nicotine reverses stabilized LTP in the hippocampal CA1 region, providing the first evidence that consolida...

journal_title：Brain research

authors： Guan X,Nakauchi S,Sumikawa K

更新日期：2006-03-17 00:00:00

abstract：:Previous work has shown that administration of corticotropin-releasing factor (CRF) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide Y (NPY), and central injection of CRF antagonist, alpha-helical CRF(9-41) enhanced NPY-induced food intake in satiated rats. The aim of the present study was ...

journal_title：Brain research

authors： Menzaghi F,Heinrichs SC,Pich EM,Tilders FJ,Koob GF

更新日期：1993-07-30 00:00:00

abstract：:In acute cats deeply anesthetized with Nembutal, monosynaptic excitatory postsynaptic potentials (EPSPs) triggered by stimulation of the ventrolateral (VL) thalamic nucleus and the pes pedunculus were recorded in large pyramidal tract cells (PT cells). Deep anesthesia, low intensities of stimulation and an averaging t...

journal_title：Brain research

authors： Deschênes M,Labelle A,Landry P

更新日期：1979-01-05 00:00:00

abstract：:The DNA content and activity of acid and alkaline deoxyribonucleases (DNases) were measured through age 60 days in the hypothalamus of female rats injected s.c. with 1.25 mg testosterone propionate 48 h after birth. DNA significantly increases through age 60 days, however, androgenization does not affect the DNases or...

journal_title：Brain research

authors： Litteria M

更新日期：1985-02-01 00:00:00