解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
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免疫学
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综合和补充性医学
医学伦理学
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医学,全科和内科
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药理学和药剂学
生理学
基本医疗保健
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心理学,临床
abstract::Midodrine hydrochloride is a peripheral alpha(1)-adrenoreceptor agonist that induces venous and arterial vasoconstriction. Midodrine, after oral or intravenous administration, undergoes enzymatic hydrolysis and releases deglymidodrine, a pharmacologically active metabolite. Midodrine and deglymidodrine have a chiral c...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20041
更新日期:2004-07-01 00:00:00
abstract::E-6087 is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2. Because E-6087 has a chiral center, this compound is a racemic mixture of two stereoisomers, (+)-(R)-E-6087 (E-6231) and (-)-(S)-E-6087 (E-6232). A normal-phase liquid-chromatographic method for the enantioselective determi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20030
更新日期:2004-05-15 00:00:00
abstract::Four racemic esters of (1R*,7aR*)-3,6,7,7a-tetrahydro-1-hydroxy-7a-methyl-1H-inden-5(2H)-one were prepared and subjected to hydrolysis with two types of hydrolases, including alcalase and three lipases. Alcalase and lipase showed opposite enantiopreference on these esters. Based on this result, we developed a gram-sca...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20023
更新日期:2004-05-05 00:00:00
abstract::An enantioseparation of the antipsychotic drug butaclamol in human plasma by high-performance liquid chromatography (HPLC) with solid phase extraction is presented. The separation was achieved on the vancomycin macrocyclic antibiotic chiral stationary phase (CSP) Chirobiotic V with a polar ionic mobile phase (PIM) con...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20001
更新日期:2004-03-01 00:00:00
abstract::Racemic ketoconazole (KTZ) was the first orally active azole antifungal agent used in clinical practice and has become widely used in the treatment of mucosal fungal infections associated with AIDS immunosuppression and cancer chemotherapy. However, the use of KTZ has been limited because of adverse drug-drug interact...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10294
更新日期:2004-02-01 00:00:00
abstract::Six secondary phosphine oxides and their tautomeric equilibria as free ligands and in the presence of an equimolar amount of the chiral dirhodium complex Rh* are described and discussed. Discrimination of enantiomers is easily possible by inspecting the (31)P NMR resonances; some (1)H and (13)C NMR resonances are usef...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10306
更新日期:2004-01-01 00:00:00
abstract::The programmed assembly of p-octiphenyl rods carrying six complementary tripeptide strands was studied in the presence of bilayer membranes using circular dichroism (CD) spectroscopy. Thermal CD experiments demonstrated programmed assembly of anionic and cationic rods into supramolecules at low temperature that irreve...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20034
更新日期:2004-01-01 00:00:00
abstract::Advances in the measurement, calculation, and application of vibrational circular dichroism (VCD) for the determination of absolute configuration are described. The purpose of the review is to provide an up-to-date perspective on the capability of VCD to solve problems of absolute stereochemistry for chiral molecules ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10287
更新日期:2003-11-01 00:00:00
abstract::Stereoselective aspects of pharmacokinetics and metabolism of a chiral nonsteroidal antiinflammatory drug, flobufen, 4-(2', 4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid, were studied in male guinea pigs after p.o. administration of racemic flobufen (rac-flobufen) at a dose of 10 mg/kg. Blood samples were coll...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10288
更新日期:2003-10-01 00:00:00
abstract::Chiral natural flavor compounds exhibit characteristic enantiomeric excesses due to stereoselective, enzymatically catalyzed reactions during biogenesis. Although the enzymatic formation of the strawberry key flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF; Furaneol(R)) is anticipated, the naturally occurr...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10247
更新日期:2003-08-01 00:00:00
abstract::A systematic and comprehensive study of the conformational spaces of the Cinchona alkaloids quinine, quinidine, cinchonine, cinchonidine, epiquinine, epiquinidine, epicinchonine, and epicinchonidine using the semiempirical PM3 method is described. The results were analyzed in terms of syn/anti and open/closed/hindered...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10265
更新日期:2003-08-01 00:00:00
abstract::Two diastereomeric cationic surfactants derived from L-proline, in which the second chiral center is a quaternary nitrogen, have been separated and fully characterized. The recognition properties of the aggregates formed by the two diastereomeric surfactants have been investigated by circular dichroism and (1)H NMR th...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10230
更新日期:2003-05-15 00:00:00
abstract::The size, sign, and profile of induced circular dichroism (CD) features in the Soret region are reliable indicators of the binding modes of porphyrins and metalloporphyrins to DNA. Porphyrins shown (using such CD criteria) to be intercalators in monodispersed DNA duplexes prove extremely useful for the detection and c...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.10206
更新日期:2003-05-05 00:00:00
abstract::The influence of latent heat dissipated by the crystallization of 1,1'-binaphthyl in its supercooled molten state on the chiral symmetry breaking transition was investigated. Temperature change in the crystallization system was monitored by infrared thermocamera. Temperature rise due to the dissipation of latent heat ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10187
更新日期:2003-03-01 00:00:00
abstract::We report here a sensitive method for the determination of the absolute configurations of primary amines using exciton-coupled circular dichroism (ECCD). The method works on a microgram scale by derivatization of chiral amines with quinoline chromophores. Complexation of the chiral ligands with metal ion fixes the geo...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10158
更新日期:2003-02-01 00:00:00
abstract::Treatment of benzoate, formate, or trifluoroacetate esters with silyldibromomethyllithiums provides alkyl silyl mixed acetals via the 1,3-rearrangement of a silyl group from carbon to oxygen. A high level of asymmetric induction onto the acetal carbon is observed when chiral alkyl esters are employed. The stereochemic...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10152
更新日期:2003-01-01 00:00:00
abstract::Anodic oxidation of 1-acetoxy-3,4-dihydronaphthalene (1) and alpha-acetoxy-beta-alkylstyrenes (3) at -78 degrees C in a mixed solvent of acetonitrile (CH(3)CN), tetrahydrofuran (THF), and acetic acid (AcOH) containing (S)-tetraethylammonium camphorsulfonate as a chiral supporting electrolyte brought about enantioselec...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10165
更新日期:2003-01-01 00:00:00
abstract::Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryost...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10269
更新日期:2003-01-01 00:00:00
abstract::Results achieved by the authors in the synthesis of chiral P,N-phosphite ligands are summarized. Three groups of new chiral P,N-phosphites are discussed, namely, ligands derived from 1,1'-bi-2-naphthol, ligands possessing an acyclic phosphorus center, and P*-chiral ligands derived from (S)-2-anilinomethylpyrrolidine. ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10258
更新日期:2003-01-01 00:00:00
abstract::An optically active spiropyran 1 with a binaphthol moiety as a chiral source was synthesized. The colored merocyanine form of (R)-1 obtained by the UV irradiation remained in the presence of D-amino acids longer than with L-amino acids. ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10111
更新日期:2002-10-01 00:00:00
abstract::1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, compound B, is a product obtained in the degradation of the anesthetic Sevoflurane. Enantiopure (+)-B was investigated using vibrational circular dichroism (VCD). Experimental absorption and VCD spectra of (+)-B in CDCl(3) solution in the 2,000-900 cm(-1) regio...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10106
更新日期:2002-08-01 00:00:00
abstract::Nine patients taking oral doses of 10 mg/12 h rac-pindolol as part of their treatment for hypertension in pregnancy were recruited for the study. Maternal and fetal gestational age ranged from 20-38 years and 28-41 weeks, respectively. Blood was collected from the umbilical cord vein and from the mother from zero to 1...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10124
更新日期:2002-08-01 00:00:00
abstract::Achiral 4-isopropyltropolone methyl ether (3) included in an optically active host compound (-)-1 yielded optically active photocyclization products (-)-5 and (-)-6 in 96 and 90% ee, respectively, upon photoirradiation in the solid state. ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10091
更新日期:2002-07-01 00:00:00
abstract::We report a method to determine the absolute configuration of alpha-amino acids by exciton coupled circular dichroism (ECCD). Naturally occurring amino acids were successfully derivatized with 2-bromomethylquinoline. Complexation of these conformationally flexible ligands with Cu(II) salts yielded defined propeller-li...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10079
更新日期:2002-06-01 00:00:00
abstract::The aim of our study was to synthesize vinylic and pyrido-fused pyridazines with a spirano moiety and to investigate their stereochemistry by spectroscopic and HPLC analyses. The vinylic compounds 5 were obtained by Knoevenagel condensation of cyclohexylidene malonates 1 with pyridazinecarbaldehyde 2. Compound 5b exhi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10096
更新日期:2002-05-15 00:00:00
abstract::Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Binding kinetics were followed by recording changes in the fluorescence of warfarin upon binding to HSA using the stopped...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10113
更新日期:2002-05-15 00:00:00
abstract::The hydrolysis and acyl migration of biosynthetic S-naproxen-beta-l-O-acyl glucuronide (I) and R-naproxen-beta-l-O-acyl glucuronide (II) was followed by HPLC. Nine first-order kinetic rate constants for the hydrolysis and acyl migration between the beta-l-O-acyl glucuronide, its alpha/beta-2, alpha/beta-3-, alpha/beta...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10047
更新日期:2002-05-05 00:00:00
abstract::2-Alkenyl- and 2-vinyl-5-pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts with significant amplification of enantiomeric excess in the enantioselective addition of diisopropylzinc to 2-alkenyl- and 2-vinylpyrimidine-5-carbaldehydes. Consecutive asymmetric autocatalysis starting from 7% ee increa...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10068
更新日期:2002-02-01 00:00:00
abstract::Allyl nitrite, O=NOCH(2)CH=CH(2), can exist in conformations which include syn (S) and anti (A) configurations of O=N-O-C, anti or gauche (G) configurations of N-O-C-C, and syn or skew (Sk) configurations of O-C-C=C. Four of them have been observed and characterized by their microwave spectra and quantum chemical calc...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10065
更新日期:2002-02-01 00:00:00
abstract::A comparison of the enantiomeric resolution of (+/-)-threo-methylphenidate (MPH) (Ritalin) was achieved on different polysaccharide based chiral stationary phases. The mobile phase used was hexane-ethanol-methanol-trifluoroacetic acid (480:9.75:9.75:0.5, v/v/v/v). Benzoic acid and phenol were used as the mobile phase ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10028
更新日期:2002-01-01 00:00:00
abstract::C(25) highly branched isoprenoid (HBI) alkenes are ubiquitous lipids found in geochemical samples around the globe. The origins of these widespread geochemicals are believed to be restricted to a limited number of diatoms, including Haslea ostrearia (and related species), Rhizosolenia setigera, and Pleurosigma interme...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.1053
更新日期:2001-08-01 00:00:00
abstract::Chiral molecules can either be handed (i.e., "shoes") or nonhanded ("potatoes"). The only chiral ligand partition for tetrahedral metal complexes (or for a tetrahedral carbon atom such as that found in amino acids and other chiral biological molecules) is the fully unsymmetrical degree 6 partition (1(4)), which leads ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.1063
更新日期:2001-08-01 00:00:00
abstract::1alpha,25-Dihydroxyvitamin D(3) (1alpha,25(OH)2D3) has been shown to modulate not only proliferation and differentiation, but also apoptosis in malignant cells, indicating that it could be useful for the treatment of cancer and psoriasis. However, little information has been available on the binding conformation of th...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.1046
更新日期:2001-07-01 00:00:00
abstract::Steady-state pharmacokinetics of indobufen (INDB) enantiomers administered as racemic INDB (rac-INDB) tablets and bleeding time were studied in patients. Two-hundred mg INDB tablets (Ibustrin) were administered twice daily for 7 days to obliterative atherosclerosis patients. Enantiospecific reversed phase (RP) HPLC wi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.1036
更新日期:2001-06-01 00:00:00
abstract::The novel chiral spirobipyridopyrans 1 and 2 were synthesized by the acid catalyzed aldol type condensation of 5-deoxypyridoxal with the appropriate ketone and subsequent reaction of the resulting pyrylium salt with base. The indolinospiropyridopyrans 3-5, which contain the modified B(6) unit, were prepared by aldol r...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/1520-636X(2001)13:2<81::AID-CHIR1002>3.0.C
更新日期:2001-02-01 00:00:00
abstract::6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by part...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.1178
更新日期:2001-01-01 00:00:00
abstract::The aim of this work was to establish structure-reactivity relationships between chiral aggregates (micelles, vesicles, and "pseudo-micelles" of amphiphilic dendrimers) and asymmetric induction. In water, micelles or vesicles formed with sugar-headed surfactants gave less than 10% ee in the reduction of prochiral keto...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/1520-636X(2001)13:1<24::AID-CHIR5>3.0.CO;2
更新日期:2001-01-01 00:00:00
abstract::Analogs of the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2 containing optically pure (R)- and (S)-2-aminotetralin-2-carboxylic acid (Atc) in position 4 were synthesized and evaluated for opioid receptor affinity. These peptides are the first reported dynorphin A analogs containing a conformationally constrained amino...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/1520-636X(2001)13:3<125::AID-CHIR1008>3.0.
更新日期:2001-01-01 00:00:00
abstract::The enantioselective hydrogenation of C==N-C group containing compounds over modified metal catalysts is as yet an uninvestigated research area. This work contains results obtained on the hydrogenation of 1-pyrroline-2-carboxylate esters and sodium salt over cinchona alkaloid-modified alumina-supported Pd catalyst. Th...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10001
更新日期:2001-01-01 00:00:00
abstract::The adsorption of heptahelicene, a helically shaped polyaromatic hydrocarbon (C(30)H(18)), on a Cu(111) surface was studied by means of thermal desorption mass spectrometry (TDMS) and low energy electron diffraction (LEED) at temperatures between 130-1,000 K under ultrahigh vacuum (UHV) conditions. The molecule in the...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.10006
更新日期:2001-01-01 00:00:00