abstract：:Bacteria have developed multiple resistance mechanisms against the most used antibiotics. In particular, zinc-dependent metallo-β-lactamase producing bacteria are a growing threat, and therapeutic options are limited. Zinc chelators have recently been investigated as metallo-β-lactamase inhibitors, as they are often a...

journal_title：Journal of inorganic biochemistry

authors： La Piana L,Viaggi V,Principe L,Di Bella S,Luzzaro F,Viale M,Bertola N,Vecchio G

更新日期：2021-02-01 00:00:00

abstract：:Previously we have shown that among 15 substituted salicyloyl (2-hydroxybenzoyl) 5-seleninic acids (SSAs) 4 compounds with longer side chains or a cyclohexyl group exhibit no glutathione peroxidase (GPx)-like activity in the coupled reductase assay. Experimental inhibition of glutathione reductase (GR) by the seleneny...

journal_title：Journal of inorganic biochemistry

authors： Yu SC,Kim IC,Ri KJ,Ri J,Kühn H

更新日期：2021-02-01 00:00:00

abstract：:A whole-cell biohybrid catalyst where a (pentamethylcyclopentadienyl)rhodium(III) (Cp*Rh(III)) complex was covalently incorporated into the cavity of nitrobindin (NB), a β-barrel protein, was prepared on an E. coli cell surface to produce isoquinolines via C(sp2)-H bond activation. In this whole-cell biohybrid system,...

journal_title：Journal of inorganic biochemistry

authors： Kato S,Onoda A,Grimm AR,Schwaneberg U,Hayashi T

更新日期：2021-01-08 00:00:00

abstract：:The preparation and performance of doped antibacterial carbon dots (CDs) have been the research hotspot. In this paper, we report the preparation of two blue light-emitting silver-doped CDs, CD-1 and CD-2, through one- and two-step routes, respectively, by using polyethyleneimine, citric acid, and AgNO3 as raw materia...

journal_title：Journal of inorganic biochemistry

authors： Zhao D,Liu X,Zhang R,Xiao X,Li J

更新日期：2021-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) generates superoxide, particularly at sub-optimal l-arginine (l-Arg) substrate concentrations. Heat shock protein 90 (Hsp90) was reported to inhibit superoxide generation from nNOS protein. However, commercially available Hsp90 product from bovine brain tissues with unspecified Hs...

journal_title：Journal of inorganic biochemistry

authors： Zheng H,Weaver JM,Feng C

更新日期：2021-01-01 00:00:00

abstract：:A series of iminopyridine complexes of platinum(II), bearing a flexible diethereal, aryl terminated residue, where the size of aryl group is varied from phenyl to 9-anthracenyl, was synthesized. The new complexes are soluble and stable in DMSO/H2O mixtures. Besides the metal center, aryl groups are available for furth...

journal_title：Journal of inorganic biochemistry

authors： Bondi R,Dalla Via L,Hyeraci M,Pagot G,Labella L,Marchetti F,Samaritani S

更新日期：2020-12-15 00:00:00

abstract：:Amphetamine-based (Amph) drugs are metabolized in humans to their hydroxylamine (AmphNHOH) and nitroso (AmphNO) derivatives. The latter metabolites are known to bind to the Fe centers of cytochrome P450 and other heme enzymes to inhibit their activities. Although these AmphNHOH/AmphNO metabolites are present in vivo, ...

journal_title：Journal of inorganic biochemistry

authors： Powell SM,Thomas LM,Richter-Addo GB

更新日期：2020-12-01 00:00:00

abstract：:We prepared and characterized new iridium(III) complexes: [Ir(NC)2(MPPIP)](PF6) (N-C = 2-phenylpyridine 1; benzo[h]quinolone 2; 1-phenylisoquinolone, 3, MPPIP = 2-(4-(4'-methylpiperazin-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline). MTT (MTT = 3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide) method ...

journal_title：Journal of inorganic biochemistry

authors： Gu Y,Wen H,Bai L,Zhou Y,Zhang H,Tian L,Zhang Y,Hao J,Liu Y

更新日期：2020-11-01 00:00:00

abstract：:Curcumin, a constituent of Curcuma longa L-Zingiberaceae is used in traditional Indian and worldwide medicine and shows anticancer and antioxidant properties. Curcumin has numerous biological and pharmacological activities but due to its hydrophobic nature, the major drawback is poor absorption and rapid elimination, ...

journal_title：Journal of inorganic biochemistry

authors： Shedge AA,Pansare SV,Khairkar SR,Chhatre SY,Chakrabarti S,Nagarkar AA,Pansare AV,Patil VR

更新日期：2020-11-01 00:00:00

abstract：:Boosting the photosensitization type I process will enhance the phototherapy efficacy because the superoxide radicals (O2-) generated during type I process are more toxic than the singlet oxygen (1O2) in type II process. Herein, [Ru(Hdtza)(phen)2][PF6] (1) and [Ru(pytz)(phen)2][PF6] (2) (phen = 1,10-phenanthroline) ba...

journal_title：Journal of inorganic biochemistry

authors： Zhang X,Huang X,Xie A,Zhang X,Deng J,Zou D,Zou J

更新日期：2020-11-01 00:00:00

abstract：:The clinical efficiency of Pt(II)-based drugs is founded on articulate mechanisms of action. Indeed it depends on a balanced combination of metal ion reactivity towards proteins and nucleic acids. Here we analysed the effect of two trans-platinum planar amines in comparison to cisplatin and transplatin on the DNA proc...

journal_title：Journal of inorganic biochemistry

authors： Pinato O,Benettazzo A,Dalla Via L,Farrell NP,Sissi C

更新日期：2020-10-01 00:00:00

abstract：:As two quite complicated substances, arsenic (As) and copper (Cu) have polluted to the environment. As is highly toxic and could cause nerve damage. Cu is involved in the occurrence of oxidative stress. The brain is one of the main target organs of heavy metal toxicity, but the damage mechanism activated by As and/or ...

journal_title：Journal of inorganic biochemistry

authors： Liu Y,Zhao H,Wang Y,Guo M,Mu M,Xing M

更新日期：2020-10-01 00:00:00

abstract：:We have analyzed the early stages of unfolding of cytochromes c-b562 (PDB ID: 2BC5) and Rd apo b562 (PDB ID: 1YYJ). Our geometrical approach proceeds from an analysis of the crystal structure reported for each protein. We quantify, residue-by-residue and region-by-region, the spatial and angular changes in the structu...

journal_title：Journal of inorganic biochemistry

authors： Kozak JJ,Gray HB,Garza-López RA

更新日期：2020-10-01 00:00:00

abstract：:To further develop the biomimetic chemistry of [FeFe]- and [NiFe]-hydrogenases for catalytic proton reduction to hydrogen (H2), two serials of dinuclear diiron and trinuclear NiFe2 dithiolate complexes with chelating PCNCP ligands, namely, Fe2(μ-edt)(CO)4{κ2-(Ph2PCH2)2NR} (1a-1c) and Fe2(CO)6(μ3-S)2Ni{(Ph2PCH2)2NR} (2...

journal_title：Journal of inorganic biochemistry

authors： Zhao PH,Li JR,Gu XL,Jing XB,Liu XF

更新日期：2020-09-01 00:00:00

abstract：:Iron overload can act as catalyst for the formation of free radicals, which may promote oxidant-mediated breast carcinogenesis. However, the association between iron and breast cancer has not been comprehensively elucidated. In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6...

journal_title：Journal of inorganic biochemistry

authors： Cheng M,Liu P,Xu LX

更新日期：2020-09-01 00:00:00

abstract：:Aiming at obtaining new copper complexes with good cytotoxicity against cancer cells, triphenylphosphine (TPP) was introduced to obtain insight into the influence of the co-ligands. In this paper, two copper complexes, Cu(2-pbmq)(CH3OH)Br2 (1) and [Cu(2-pbmq)(TPP)Br]2 (2) were designed, synthesized, and characterized ...

journal_title：Journal of inorganic biochemistry

authors： Li S,Zhao J,Guo Y,Mei Y,Yuan B,Gan N,Zhang J,Hu J,Hou H

更新日期：2020-09-01 00:00:00

abstract：:Classical molecular dynamic simulations and density functional theory are used to unveil the interaction of aluminum with various phosphorylated derivatives of the fragment KSPVPKSPVEEKG (NF13), a major multiphosphorylation domain of human neurofilament medium (NFM). Our calculations reveal the rich coordination chemi...

journal_title：Journal of inorganic biochemistry

authors： Grande-Aztatzi R,Formoso E,Mujika JI,de Sancho D,Lopez X

更新日期：2020-09-01 00:00:00

abstract：:We investigated new development in photodynamic therapy (PDT), aiming at enhanced tumor selectivity and biocompatibility, which included application of a third-generation photosensitizing agent, i.e. xanthene-origin Rose Bengal (RB) co-encapsulated with up-converting NaYF4 nanoparticles (NPs) co-doped with lanthanide ...

journal_title：Journal of inorganic biochemistry

authors： Bazylińska U,Wawrzyńczyk D,Szewczyk A,Kulbacka J

更新日期：2020-07-01 00:00:00

abstract：:The antiproliferative properties of a series of structurally-related gold(I) and silver(I) linear complexes inspired to the clinically established gold-based drug auranofin were investigated in A2780 ovarian cancer cells and in their auranofin (A2780/AF-R) and cisplatin (A2780/CDDP-R) resistant counterparts. In A2780 ...

journal_title：Journal of inorganic biochemistry

authors： Landini I,Massai L,Cirri D,Gamberi T,Paoli P,Messori L,Mini E,Nobili S

更新日期：2020-07-01 00:00:00

abstract：:Since the 1970s, the biological role of vanadium compounds has been discussed as insulin-mimetic or insulin-enhancer agents. The action of vanadium compounds has been investigated to determine how they influence the insulin signaling pathway. Khan and coworkers proposed key proteins for the insulin pathway study, intr...

journal_title：Journal of inorganic biochemistry

authors： Treviño S,Diaz A

更新日期：2020-07-01 00:00:00

abstract：:Interactions of three Ru(II) chlorophenyl terpyridine complexes: [Ru(Cl-Ph-tpy)(en)Cl]Cl (1), [Ru(Cl-Ph-tpy)(dach)Cl]Cl (2) and [Ru(Cl-Ph-tpy)(bpy)Cl]Cl (3) (Cl-Ph-tpy = 4'-(4-chlorophenyl)-2,2':6',2''-terpyridine, en = 1,2-diaminoethane, dach = 1,2-diaminocyclohexane, bpy = 2,2'-bipyridine) with human serum albumin (...

journal_title：Journal of inorganic biochemistry

authors： Masnikosa R,Milutinović MM,Crnolatac I,Tot A,Veličković S,Bojić-Trbojević Ž,Rilak-Simović A

更新日期：2020-07-01 00:00:00

abstract：:A photostable Ru(2,2-biquinoline)2(3-(2-pyridyl)-5-(4-carboxyphenyl)-1,2,4-triazolate) (Ru(biq)2(trzbenzCOOH)) complex that exhibits near-infrared (NIR) emission centred at 786 nm is reported. The parent complex was conjugated via amide coupling to a cell-penetrating peptide sequence octa-arginine (R8), and two signal...

journal_title：Journal of inorganic biochemistry

authors： Cullinane D,Gkika KS,Byrne A,Keyes TE

更新日期：2020-06-01 00:00:00

abstract：:A set of new copper(II) complexes containing the Schiff base ligand derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil (6-amino-1,3-dimethyl-5-[(pyridin-2-ylmethylidene)-amino]-pyrimidine-2,4(1H,3H)-dione) with several anions (Cl-, Br-, I-, ClO4-, NO3-) and, two of them with 1,10-phenanthroline,...

journal_title：Journal of inorganic biochemistry

authors： Illán-Cabeza NA,Jiménez-Pulido SB,Hueso-Ureña F,Ramírez-Expósito MJ,Martínez-Martos JM,Moreno-Carretero MN

更新日期：2020-06-01 00:00:00

abstract：:The 1,7-diacetate-4,10-diacetamide substituted 1,4,7,10-tetraazacyclododecane structural unit is common to several responsive Magnetic Resonance Imaging (MRI) contrast agents (CAs). While some of these complexes (agents capable of sensing fluctuations in Zn2+, Ca2+ etc. ions) have already been tested in vivo, the deta...

journal_title：Journal of inorganic biochemistry

authors： Tircsó G,Tircsóné Benyó E,Garda Z,Singh J,Trokowski R,Brücher E,Sherry AD,Tóth É,Kovács Z

更新日期：2020-05-01 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) contribute to tumour progression and have received significant attention as a therapeutic target. These cells produce growth factors, cytokines and chemokines, stimulating cancer cell proliferation and inhibiting their apoptosis. Recent advances in drug delivery have demonstrated a...

journal_title：Journal of inorganic biochemistry

authors： Ferraz FS,López JL,Lacerda SMSN,Procópio MS,Figueiredo AFA,Martins EMN,Guimarães PPG,Ladeira LO,Kitten GT,Dias FF,Domingues RZ,Costa GMJ

更新日期：2020-05-01 00:00:00

abstract：:In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF6, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor ce...

journal_title：Journal of inorganic biochemistry

authors： Graminha AE,Honorato J,Dulcey LL,Godoy LR,Barbosa MF,Cominetti MR,Menezes AC,Batista AA

更新日期：2020-05-01 00:00:00

abstract：:Several studies have focused on the antimicrobial effects of cerium oxide nanoparticles (CeO2-NP) but few have focused on their effects on bacteria under initial biofilm formation conditions. Streptococcus mutans is a prolific biofilm former contributing to dental caries in the presence of fermentable carbohydrates an...

journal_title：Journal of inorganic biochemistry

authors： Bhatt L,Chen L,Guo J,Klie RF,Shi J,Pesavento RP

更新日期：2020-05-01 00:00:00

abstract：:Two novel pyrazole based thiourea palladium(II) complexes, [PdCl(PPh3)(C9H8NO2S-pz)] (1) and [PdCl(PPh3)(C14H10NO2S-pz)] (2) [pz = pyrazole (C3H2N2)] have been obtained unexpectedly from chromone thiosemicarbazones (L1 and L2) and [PdCl2(PPh3)2]. The compounds have been fully characterized by physicochemical studies. ...

journal_title：Journal of inorganic biochemistry

authors： Haribabu J,Balachandran C,Tamizh MM,Arun Y,Bhuvanesh NSP,Aoki S,Karvembu R

更新日期：2020-04-01 00:00:00

abstract：:Signal transduction in plants determines their successful adaptation to diverse stress factors. Our group employed suspension cells to study the phosphoinositide pathway, which is triggered by aluminium stress. We investigated about members of the PI-specific phospholipase C (PLC) family and evaluated their transcript...

journal_title：Journal of inorganic biochemistry

authors： González-Mendoza VM,Sánchez-Sandoval ME,Munnik T,Hernández-Sotomayor SMT

更新日期：2020-03-01 00:00:00

abstract：:Polythiol binding of metal ions plays crucial role in the proper functioning of cysteine-rich proteins that are responsible for metal homeostasis and defending processes against metal toxicity (including heavy metals detoxification). The coordination properties of cysteine residues involved in specific sequencional pa...

journal_title：Journal of inorganic biochemistry

authors： Krzywoszyńska K,Swiątek-Kozłowska J,Potocki S,Ostrowska M,Kozłowski H

更新日期：2020-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative treatment widely used against cancer. PDT requires molecular systems, known as photosensitizers (PS), which not only exhibit strong absorption at a particular wavelength range, but also need to be selectively accumulated inside cancer cells. PS are activated by specific wav...

journal_title：Journal of inorganic biochemistry

authors： Noriega L,Castro ME,Perez-Aguilar JM,Caballero NA,Sanchez-Gaytan BL,González-Vergara E,Melendez FJ

更新日期：2020-02-01 00:00:00

abstract：:Radionuclide internal contamination can induce chemical and radioactive intoxication and produce harmful free radicals in vivo. At present, administration of chelating agents is the most effective treatment against nuclide contamination. However, traditional studies on chelating agents have ignored the damage caused b...

journal_title：Journal of inorganic biochemistry

authors： Zheng T,Wan X,Zhang Q,Jin B,Peng RF

更新日期：2020-02-01 00:00:00

abstract：:Uranium is an element belonging to the actinide series. It is ubiquitous in rock, soil, and water. Uranium is found in the ecosystem due to mining and milling industrial activities and processing to nuclear fuel, but also to the extensive use of phosphate fertilizers. Understanding uranium binding in vivo is critical,...

journal_title：Journal of inorganic biochemistry

authors： Garai A,Delangle P

更新日期：2020-02-01 00:00:00

abstract：:Fourteen new complexes were obtained from Ln(III)(NO3)3∙n-H2O and the chromophores 2-(1H-benzo[d]imidazol-2-yl)-phenol (Bzp1) or 2-(5-methyl-1H-benzo[d]imidazol-2-yl)-phenol (Bzp2). The complete characterization allowed us to assign unequivocally the structures of all the complexes. The techniques used for this purpos...

journal_title：Journal of inorganic biochemistry

authors： Hernández-Morales A,Rivera JM,López-Monteon A,Lagunes-Castro S,Castillo-Blum S,Cureño-Hernández K,Flores-Parra A,Villaseñor-Granados O,Colorado-Peralta R

更新日期：2019-12-01 00:00:00

abstract：:Amino acid replacement is a useful strategy to assess the roles of axial heme ligands in the function of native heme proteins. THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin that uses a lysine residue in the E helix (Lys53, at position E10 by reference to myoglo...

journal_title：Journal of inorganic biochemistry

authors： Nye DB,Johnson EA,Mai MH,Lecomte JTJ

更新日期：2019-12-01 00:00:00

abstract：:This work describes in situ synthesis and application of the zinc glutamate Bio Metal-Organic Framework (BioMOF) supported on cellulose fabrics as a dual material for nitric oxide (NO) and 5-fluorouracil (5FU) controlled delivery for wound and/or skin cancer therapy. In situ synthesis of BioMOF on the cotton fabric wa...

journal_title：Journal of inorganic biochemistry

authors： Noorian SA,Hemmatinejad N,Navarro JAR

更新日期：2019-12-01 00:00:00

abstract：:The study of the metal binding pattern of N-methyladenines (1-, 3-, 7- or 9-Meade) towards CuII-iminodiacetate-like chelates is addressed on the basis of XRD crystal structures of sixteen novel ternary compounds. Except for three compounds, all others feature an square-based Cu(II) coordination, type 4 + 1, and the ef...

journal_title：Journal of inorganic biochemistry

authors： García-Rubiño ME,Barceló-Oliver M,Castiñeiras A,Domínguez-Martín A

更新日期：2019-11-01 00:00:00

abstract：:Antibody drug conjugates have emerged as a very attractive type of targeted therapy in cancer. They combine the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutics. This review focuses on antibody drug conjugates based on metal-containing cytotoxic payloads. We...

journal_title：Journal of inorganic biochemistry

authors： Del Solar V,Contel M

更新日期：2019-10-01 00:00:00

abstract：:Alpha-glucosidase is considered to be an important target for the treatment of noninsulin-dependent diabetes. In this work, the inhibitory effects of polyoxometalates (POMs) affected by three different factors (heteroatom, transition metal substitution element and vanadium substitution number) on α-glucosidase were st...

journal_title：Journal of inorganic biochemistry

authors： Chi G,Wang L,Chen B,Li J,Hu J,Liu S,Zhao M,Ding X,Li Y

更新日期：2019-10-01 00:00:00

abstract：:A micro-electrochemical reaction cell was coupled to an electrospray mass spectrometer in order to track redox transformations for two representative medicinal gold compounds - i.e. [(2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S)(triethylphosphine)gold(I)] and [Au(bipydmb-H)(OH)][PF6] (where bipydmb-H is deprot...

journal_title：Journal of inorganic biochemistry

authors： Kupiec M,Ziółkowski R,Massai L,Messori L,Pawlak K

更新日期：2019-09-01 00:00:00