Relationship between the antiproliferative properties of Cu(II) complexes with the Schiff base derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil and the redox status mediated by antioxidant defense systems on glioma tumoral cells.

abstract：:In the quest for more effective pain palliation radiopharmaceuticals for metastatic bone cancer, this paper relates results obtained with 166Ho complexed to the bone-seeking bisphosphonate, 1-hydroxy-4-aminopropililydenediphosphonate (APD). APD is itself a bone cancer pain palliation agent and this work was therefore ...

journal_title：Journal of inorganic biochemistry

authors： Zeevaart JR,Jarvis NV,Louw WK,Jackson GE,Cukrowski I,Mouton CJ

更新日期：1999-04-01 00:00:00

abstract：:The three dinuclear silver(I) complexes of N-heterocyclic carbene (NHC) ligands, [Ag2(L-1a)](PF6)2·2CH3CN (Ag-1a), [Ag2(L-2)2](PF6)2·H2O (Ag-2), and [Ag2(L-4)2](PF6)2·2CH3CN (Ag-4), were synthesized by reactions of Ag2O with the corresponding PF6- salt of the NHC precursors indicated as H4L-1(PF6)4, H2L-2(PF6)2, and H...

journal_title：Journal of inorganic biochemistry

authors： Sakamoto R,Morozumi S,Yanagawa Y,Toyama M,Takayama A,Kasuga NC,Nomiya K

更新日期：2016-10-01 00:00:00

abstract：:The syntheses, characteristics of dinuclear macrocyclic polyamine zinc complexes and their interaction with plasmid DNA are reported. The two cyclen (1,4,7,10-tetraazacyclododecane) moieties are bridged by rigid and flexible linkages. The crystal structures of Zn2C27H43N8O15Cl4 [5c.(ClO4)3.2H2O] and Zn2C30H43N10O13Cl3...

journal_title：Journal of inorganic biochemistry

authors： Xiang QX,Zhang J,Liu PY,Xia CQ,Zhou ZY,Xie RG,Yu XQ

更新日期：2005-08-01 00:00:00

abstract：:The synthesis, characterization, and antitumor activity of a series of platinum(IV) complexes of the type DACH-PtIV(X)2Y (where DACH = trans-dl, or trans-l-1,2-diaminocyclohexane, X = OH or Cl, and Y = oxalato, malonato, methylmalonato, tartronato, ketomalonato, 1,1-cyclopropanedicarboxylato, or 1,1-cyclobutanedicarbo...

journal_title：Journal of inorganic biochemistry

authors： Khokhar AR,al-Baker S,Siddik ZH

更新日期：1994-04-01 00:00:00

abstract：:Copper(II) and nickel(II) complexes of the terminally protected nonapeptide Ac-SGAEGHHQK-NH2 modeling the metal binding sites of the (8-16) domain of amyloid-β have been studied by potentiometric, UV-vis, CD and ESR spectroscopic methods. The studies on the mutants containing only one of the histidyl residues (Ac-SGAE...

journal_title：Journal of inorganic biochemistry

authors： Grenács Á,Sanna D,Sóvágó I

更新日期：2015-10-01 00:00:00

abstract：:The heme of neuronal nitric oxide synthase (nNOS) participates in O2 activation but also binds self-generated NO, resulting in reversible feedback inhibition. We utilized mutagenesis to investigate if a conserved tryptophan residue (Trp409), which engages in pi-stacking with the heme and hydrogen bonds to its axial cy...

journal_title：Journal of inorganic biochemistry

authors： Adak S,Stuehr DJ

更新日期：2001-02-01 00:00:00

abstract：:A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positio...

journal_title：Journal of inorganic biochemistry

authors： Iglesias BA,Barata JFB,Pereira PMR,Girão H,Fernandes R,Tomé JPC,Neves MGPMS,Cavaleiro JAS

更新日期：2015-12-01 00:00:00

abstract：:Since the 1970s, the biological role of vanadium compounds has been discussed as insulin-mimetic or insulin-enhancer agents. The action of vanadium compounds has been investigated to determine how they influence the insulin signaling pathway. Khan and coworkers proposed key proteins for the insulin pathway study, intr...

journal_title：Journal of inorganic biochemistry

authors： Treviño S,Diaz A

更新日期：2020-07-01 00:00:00

abstract：:Manganese peroxidase (MnP) is an extracellular heme enzyme produced by the lignin-degrading white-rot fungus Phanerochaete chrysosporium. MnP catalyzes the peroxide-dependent oxidation of Mn(II) to Mn(III). The Mn(III) is released from the enzyme in complex with oxalate, enabling the oxalate-Mn(III) complex to serve a...

journal_title：Journal of inorganic biochemistry

authors： Sundaramoorthy M,Gold MH,Poulos TL

更新日期：2010-06-01 00:00:00

abstract：:As two quite complicated substances, arsenic (As) and copper (Cu) have polluted to the environment. As is highly toxic and could cause nerve damage. Cu is involved in the occurrence of oxidative stress. The brain is one of the main target organs of heavy metal toxicity, but the damage mechanism activated by As and/or ...

journal_title：Journal of inorganic biochemistry

authors： Liu Y,Zhao H,Wang Y,Guo M,Mu M,Xing M

更新日期：2020-10-01 00:00:00

abstract：:In this study we report the synthesis, characterization and a thorough biological evaluation of twelve organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes. The chosen hqH ligands bear various halogen atoms in different positions which enables to study effect of the substituents on physico-chemical and biological pr...

journal_title：Journal of inorganic biochemistry

authors： Kljun J,León IE,Peršič Š,Cadavid-Vargas JF,Etcheverry SB,He W,Bai Y,Turel I

更新日期：2018-09-01 00:00:00

abstract：:The entire polypeptide of hyperthermophilic Pyrococcus furiosus rubredoxin was synthesized in order to specifically probe structural determinants of protein thermostability. The uv-visible, circular dichroic, electron paramagnetic, and nuclear magnetic resonance spectra, and electrochemical properties, of the native a...

journal_title：Journal of inorganic biochemistry

authors： Christen R,Jancic T,Zhou ZH,Adams MW,Tomich JM,Smith ET

更新日期：1997-01-01 00:00:00

abstract：:Partially purified selenoprotein P from rat plasma was digested with either trypsin, endoprotease Lys-C, or endoprotease Arg-C and analyzed by high pressure liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis. Several 75Se-labeled peptides were detected. The moles of selenium in selenop...

journal_title：Journal of inorganic biochemistry

authors： Motchnik PA,Tappel AL

更新日期：1990-11-01 00:00:00

abstract：:Tree laccase, a multi-copper oxidase, has been studied as a copper donor in conjunction with the demetalated forms of three blue copper proteins. Copper transfer could be observed under reducing conditions in the absence of air. Only about 10% of the total copper in laccase could be transferred regardless of the amoun...

journal_title：Journal of inorganic biochemistry

authors： Meadows KA,Morie-Bebel MM,McMillin DR

更新日期：1991-03-01 00:00:00

abstract：:New heteroditopic, bi- and multidentate imino- and aminophosphine ligands were synthesised and complexed to [AuCl(THT)] (THT=tetrahydrothiophene). X-ray crystallography confirmed Schiff base formation in three products, the successful reduction of the imino-group to the sp(3)-hybridised amine in several instances, and...

journal_title：Journal of inorganic biochemistry

authors： Traut-Johnstone T,Kanyanda S,Kriel FH,Viljoen T,Kotze PD,van Zyl WE,Coates J,Rees DJ,Meyer M,Hewer R,Williams DB

更新日期：2015-04-01 00:00:00

abstract：:The N-terminal protected and unprotected peptides MAHHEEQHG-NH(2), Ac-MAHHEEQHG-NH(2) from Hpn (Helicobacter histidine-rich protein) and MAHHEQQQQQQA-NH(2), Ac-MAHHEQQQQQQA-NH(2) from Hpn-like protein, respectively, were synthesized and their interactions with Cu(2+) and Ni(2+) ions were studied by potentiometric, UV-...

journal_title：Journal of inorganic biochemistry

authors： Witkowska D,Bielinska S,Kamysz W,Kozlowski H

更新日期：2011-02-01 00:00:00

abstract：:A heterodinuclear (Ru(II), Co(III)) metal polypyridyl complex [(phen)(2)Ru(bpibH(2))Co(phen)(2)](5+) {phen = 1,10-phenanthroline, bpibH(2) = 1,4-bis([1,10]phebanthroline-[5,6-d]imidazol-2-yl)-benzene} has been designed and synthesized. The comparative study on the interactions of the Ru(II)-Co(III) complex with calf t...

journal_title：Journal of inorganic biochemistry

authors： Liang X,Zou X,Tan L,Zhu W

更新日期：2010-12-01 00:00:00

abstract：:Four related ruthenium(III) complexes, with the formula mer-[RuCl(3)(dmso)(N-N)] (dmso=dimethyl sulfoxide; N-N=2,2'-bipyridine (1), 1,10-phenantroline (2), dipyrido[3,2-f:2',3'-h]quinoxaline (3) and dipyrido[3,2-a:2',3'-c]phenazine (4)), have been reported. Complexes 3 and 4 are newly synthesized and characterized by ...

journal_title：Journal of inorganic biochemistry

authors： Tan C,Liu J,Chen L,Shi S,Ji L

更新日期：2008-08-01 00:00:00

abstract：:A dimeric copper complex of the unsubstituted pyridoxal thiosemicarbazone (H(2)L), [[Cu(HL)(OH(2))](2)]Cl(2).2H(2)O, previously tested on Friend murine cell lines has been recently resynthesized to evaluate its behavior on different murine and human leukemic cell lines and has been compared, in vitro and in vivo, with...

journal_title：Journal of inorganic biochemistry

authors： Belicchi Ferrari M,Bisceglie F,Pelosi G,Tarasconi P,Albertini R,Dall'Aglio PP,Pinelli S,Bergamo A,Sava G

更新日期：2004-02-01 00:00:00

abstract：:Dysregulation of apoptosis and necrosis is central to many diseases and non-invasive imaging of cell death is an important clinical objective to stage disease or to monitor treatment progress. The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysin...

journal_title：Journal of inorganic biochemistry

authors： Hueting R,Tavaré R,Dilworth JR,Mullen GE

更新日期：2013-11-01 00:00:00

abstract：:Aggregation of amyloid β-proteins (Aβ) induced by Cu2+ is a crucial element in the pathogenesis of Alzheimer's disease (AD), and cerebral acidosis is a common complication of AD. Under mildly acidic conditions, Cu2+-Aβ species have higher tendency to generate neurotoxic aggregates. Hence it is of significance to devel...

journal_title：Journal of inorganic biochemistry

authors： Xie B,Liu F,Dong X,Wang Y,Liu XM,Sun Y

更新日期：2017-06-01 00:00:00

abstract：:The effect on Cu metabolism of two organic Mo compounds, cysteine-Mo (CM) and cysteine-Mo-S (CMS), and of an inorganic compound, tetrathiomolybdate (TTM), was investigated in sheep. Intravenous administration of CMS or TTM increased total plasma Cu concentrations and promoted the appearance of trichloroacetic acid (TC...

journal_title：Journal of inorganic biochemistry

authors： Allen JD,Gawthorne JM

更新日期：1986-06-01 00:00:00

abstract：:The plasmid DNA scission by the restriction enzyme HaeIII was investigated in the presence of tetrakis(1-methylpyridinium-4-yl)porphyrin (H2TMPyP) and its manganese(III), iron(III), nickel(II), cobalt(III) and zinc(II) derivatives. The effect of metalloporphyrins on plasmid DNA cleavage was ascertained by gel electrop...

journal_title：Journal of inorganic biochemistry

authors： Tabata M,Nakajima K,Nyarko E

更新日期：2000-03-01 00:00:00

abstract：:The title compound ([3,5-Me(2)bpzaH(2)][AuCl(4)]Cl, 1) (Me(2)bpza=bis(3,5-dimethylpyrazolyl)acetic acid), was prepared by reacting H[AuCl(4)] with 3,5-Me(2)bpza; and spectroscopically and structurally characterized. In the solid state structure of 1, the pyrazolyl ligand is doubly protonated to form two strong charge ...

journal_title：Journal of inorganic biochemistry

authors： Fonteh PN,Keter FK,Meyer D,Guzei IA,Darkwa J

更新日期：2009-02-01 00:00:00

abstract：:A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) co...

journal_title：Journal of inorganic biochemistry

authors： Barbosa ASL,Guedes JS,da Silva DR,Meneghetti SMP,Meneghetti MR,da Silva AE,de Araujo MV,Alexandre-Moreira MS,de Aquino TM,de Siqueira Junior JP,de Araújo RSA,da Cruz RMD,Mendonça-Junior FJB

更新日期：2018-03-01 00:00:00

abstract：:In this brief review the most recent studies and the most relevant aspects of the complexes generated by interaction of carbohydrates and related molecules with the oxovanadium(IV) cation, VO(2+), are presented and discussed. The survey includes complexes of mono-, di- and polysaccharides, and of other molecules relat...

journal_title：Journal of inorganic biochemistry

authors： Baran EJ

更新日期：2009-04-01 00:00:00

abstract：:Synthetic and spectroscopic studies of the Hg(II) and MeHg(II) complexes of azathioprine (AZA), a biologically active 6-mercaptopurine derivative, were undertaken. The altered coordination behavior of AZA with respect to the parent mercaptopurine, with sulfur no longer being the primary donor atom, was confirmed. As c...

journal_title：Journal of inorganic biochemistry

authors： Chifotides HT,Dunbar KR,Katsaros N,Pneumatikakis G

更新日期：1994-08-15 00:00:00

abstract：:Vanadium has well-documented blood-glucose-lowering properties both in vitro and in vivo. The design of new oxovanadium(IV) coordination compounds, intended for use as insulin-enhancing agents in the treatment of diabetes mellitus, can potentially benefit from a synergistic approach, in which the whole complex has mor...

journal_title：Journal of inorganic biochemistry

authors： Woo LC,Yuen VG,Thompson KH,McNeill JH,Orvig C

更新日期：1999-09-30 00:00:00

abstract：:A systematic density functional theory study supported by extended X-ray absorption fine structure (EXAFS) and infrared spectroscopic data was conducted to elucidate how structure and vibrational spectra of aqueous desferrioxamine B (DFOB) metal complexes vary with the metal ion identity. Structural parameters derived...

journal_title：Journal of inorganic biochemistry

authors： Kruft BI,Harrington JM,Duckworth OW,Jarzęcki AA

更新日期：2013-12-01 00:00:00

abstract：:Hexacyanochromate ion, (Cr(CN)6)3-, was applied to ribonuclease T1 (RNase T1), which specifically cleaves RNA chains at guanylic acid residues. From kinetic studies, this anion was shown to bind to the active site of RNase T1 as a competitive inhibitor. Therefore, the line broadening effect of NMR resonances due to bi...

journal_title：Journal of inorganic biochemistry

authors： Inagaki F,Shimada I

更新日期：1986-10-01 00:00:00