Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes.

abstract：:The active site of [NiFe] hydrogenase is a binuclear metal complex composed of Fe and Ni atoms and is called the Ni-Fe site, where the Fe atom is known to be coordinated to three diatomic ligands. Two mass spectrometric techniques, pyrolysis-MS (pyrolysis-mass spectrometry) and TOF-SIMS (time-of-flight secondary ion m...

journal_title：Journal of inorganic biochemistry

authors： Higuchi Y,Toujou F,Tsukamoto K,Yagi T

更新日期：2000-07-01 00:00:00

abstract：:The reactivities of copper(II) complexes with histidine-containing oligopeptides towards active oxygen species such as hydrogen peroxide (H2O2) and superoxide ion (O2-) were investigated by electron spin resonance (ESR)-spin trapping and thiobarbituric acid (TBA) methods. At physiological pH values, Cu(II) complexes w...

journal_title：Journal of inorganic biochemistry

authors： Ueda J,Ozawa T,Miyazaki M,Fujiwara Y

更新日期：1994-08-01 00:00:00

abstract：:Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation. As a result of the amphiphilic properties of these siderophores it is difficult to study siderophore-mediated uptake of iron, because the a...

journal_title：Journal of inorganic biochemistry

authors： Martinez JS,Butler A

更新日期：2007-11-01 00:00:00

abstract：:Neuroglobin is a monomeric globin containing a six-coordinate heme b, expressed in the nervous system, which exerts an important neuroprotective role. In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of...

journal_title：Journal of inorganic biochemistry

authors： Bellei M,Bortolotti CA,Di Rocco G,Borsari M,Lancellotti L,Ranieri A,Sola M,Battistuzzi G

更新日期：2018-01-01 00:00:00

abstract：:The effect of Cu(II), Ni(II), Zn(II), Mg(II), and Mn(II) on the fluorescence of porcine kidney cytosol leucine aminopeptidase and three of its dansyl(Dns) peptide substrates, Leu-Gly-NHNH-Dns, Leu-Gly-NH(CH2)2NH-Dns, and Leu-Gly-NH(CH2)6NH-Dns, has been investigated. These five metal ions were chosen for study because...

journal_title：Journal of inorganic biochemistry

authors： Lin WY,Van Wart HE

更新日期：1988-01-01 00:00:00

abstract：:Amphetamine-based (Amph) drugs are metabolized in humans to their hydroxylamine (AmphNHOH) and nitroso (AmphNO) derivatives. The latter metabolites are known to bind to the Fe centers of cytochrome P450 and other heme enzymes to inhibit their activities. Although these AmphNHOH/AmphNO metabolites are present in vivo, ...

journal_title：Journal of inorganic biochemistry

authors： Powell SM,Thomas LM,Richter-Addo GB

更新日期：2020-12-01 00:00:00

abstract：:Vanadate in aqueous solution is known to influence a number of enzyme-catalyzed reactions. Such effects are well known to carry over to living systems where numerous responses to the influence of vanadium have been well-documented; perhaps the most studied being the insulin-mimetic effect. Studies of the aqueous chemi...

journal_title：Journal of inorganic biochemistry

authors： Bhattacharyya S,Tracey AS

更新日期：2001-05-01 00:00:00

abstract：:The water-insoluble and water-soluble organotin(IV)porphinate complexes based on the tris-(4-pyridinyl)porphyrin and tris(N-methyl-4-pyridiniumyl)porphyrin moieties were synthesized and characterized by elemental analysis, (1)H NMR, IR and electrospray ionization mass spectra. The in vitro activity of the compounds ag...

journal_title：Journal of inorganic biochemistry

authors： Han G,Yang P

更新日期：2002-07-25 00:00:00

abstract：:Five new heterocyclic gold carbene complexes were prepared, four chlorido-[1,3-dimethyl-4,5-diarylimidazol-2-ylidene]gold complexes 6a-d and a chlorido-[1,3-dibenzylimidazol-2-ylidene]gold complex 11, and three of them were characterised by X-ray single crystal analyses. They were tested for cytotoxicity against a pan...

journal_title：Journal of inorganic biochemistry

authors： Kaps L,Biersack B,Müller-Bunz H,Mahal K,Münzner J,Tacke M,Mueller T,Schobert R

更新日期：2012-01-01 00:00:00

abstract：:Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance for all three aspects of cellular iron metabolism at the level ...

journal_title：Journal of inorganic biochemistry

authors： Kühn LC,Hentze MW

更新日期：1992-08-15 00:00:00

abstract：:Copper is an essential metal ion to many living organisms, including mammals, as it mediates a wide variety of important biochemical processes. At elevated concentrations, copper is extremely toxic to host cells. This paradoxical nature of copper has necessitated a highly regulated procedure for its cellular accumulat...

journal_title：Journal of inorganic biochemistry

authors： Presta A,Stillman MJ

更新日期：1997-06-01 00:00:00

abstract：SYNOPSIS:MnII complexes formed with cis- and trans-DO2A (DO2A=1,4,7,10-tetraazacyclododecane-1,4 (or 1,7) -diacetic acid) chelators were investigated by pH-potentiometry, 1H relaxometry, UV-vis spectrophotometry and cyclic voltammetry. The physico-chemical characteristics of MnII complexes of these structure isomers do...

journal_title：Journal of inorganic biochemistry

authors： Garda Z,Forgács A,Do QN,Kálmán FK,Timári S,Baranyai Z,Tei L,Tóth I,Kovács Z,Tircsó G

更新日期：2016-10-01 00:00:00

abstract：:Subcellular fractions were prepared by differential centrifugation from heart and liver of a lamb labeled with 75Se-selenite. Crude fractions of nuclei, mitochondria, and microsomes from both tissues were solubilized with sodium dodecyl sulfate and chromatographed on columns of sephacryl S-200. A low molecular weight ...

journal_title：Journal of inorganic biochemistry

authors： Beilstein MA,Tripp MJ,Whanger PD

更新日期：1981-12-01 00:00:00

abstract：:Shape analysis of coordination complexes is well-suited to evaluate the subtle distortions in the trigonal bipyramidal (TBPY-5) geometry of vanadium coordinated in the active site of phosphatases and characterized by X-ray crystallography. Recent studies using the tau (τ) analysis support the assertion that vanadium i...

journal_title：Journal of inorganic biochemistry

authors： Sánchez-Lombardo I,Alvarez S,McLauchlan CC,Crans DC

更新日期：2015-06-01 00:00:00

abstract：:A new anticancer-active platinum(II) compound [Pt(A9pyp)(dmso)(cbdca)], containing the E-1-(9-anthryl)-3-(2-pyridyl)-2-propenone ligand (abbreviated as A9pyp) has been synthesized by the replacement of the anionic chloride ligands in cis-[Pt(A9pyp)(dmso)Cl(2)] by the dianionic chelating cyclobutanedicarboxylate ligand...

journal_title：Journal of inorganic biochemistry

authors： Marqués-Gallego P,Contaldi S,den Dulk H,Monari M,Brouwer J,Jaehde U,Kalayda GV,Reedijk J

更新日期：2009-12-01 00:00:00

abstract：:The transient kinetics of proton pumping and the electron transfer properties of cytochrome oxidase inserted into small unilamellar vesicles have been investigated by stopped-flow spectrophotometry. In the presence of valinomycin, proton pumping and cytochrome c oxidation by cytochrome oxidase are synchronous up to ra...

journal_title：Journal of inorganic biochemistry

authors： Brunori M,Antonini G,Colosimo A,Malatesta F,Sarti P,Jones MG,Wilson MT

更新日期：1985-03-01 00:00:00

abstract：:The binding and reactivity of the hydrosulfide ion (HS-) to iron(II) porphyrinates has been examined for several synthetic meso-tetraphenylporphine (TPP) derivatives. In all cases, HS- coordinates to the iron centers in a 1:1 stoichiometry with formation constants (Kf) that reflect the electronic characteristics of th...

journal_title：Journal of inorganic biochemistry

authors： Meininger DJ,Arman HD,Tonzetich ZJ

更新日期：2017-02-01 00:00:00

abstract：:In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms t...

journal_title：Journal of inorganic biochemistry

authors： MacDonald TC,Nehzati S,Sylvain NJ,James AK,Korbas M,Caine S,Pickering IJ,George GN,Krone PH

更新日期：2015-10-01 00:00:00

abstract：:We have studied the ground state of a realistic model of oxyheme with multiconfigurational second-order perturbation theory (CASPT2). Our results show that the ground-state electronic structure is strongly multiconfigurational in character. Thus, the wavefunction is a mixture of many different configurations, of which...

journal_title：Journal of inorganic biochemistry

authors： Jensen KP,Roos BO,Ryde U

更新日期：2005-01-01 00:00:00

abstract：:Xyloglucan is degraded by a mixture of copper(II), hydrogen peroxide and ascorbate. In the presence of ascorbate and/or hydrogen peroxide, copper(II) species were rapidly reduced to copper(I), which react with hydrogen peroxide. Spin-trapping experiments showed that hydroxyl radicals formed and attacked xyloglucan cau...

journal_title：Journal of inorganic biochemistry

authors： Tabbì G,Fry SC,Bonomo RP

更新日期：2001-04-01 00:00:00

abstract：:Tree laccase, a multi-copper oxidase, has been studied as a copper donor in conjunction with the demetalated forms of three blue copper proteins. Copper transfer could be observed under reducing conditions in the absence of air. Only about 10% of the total copper in laccase could be transferred regardless of the amoun...

journal_title：Journal of inorganic biochemistry

authors： Meadows KA,Morie-Bebel MM,McMillin DR

更新日期：1991-03-01 00:00:00

abstract：:Twenty ferritin samples were prepared at pH 6.5 with average loadings of 0-89 Fe atoms per molecule. Nuclear magnetic relaxation times T1 and T2 were measured at 3 degrees C, 23 degrees C, and at 37 degrees C and at field strength from 0.025 to 1.5 T. The field dependence, temperature dependence, and approximate equal...

journal_title：Journal of inorganic biochemistry

authors： Vymazal J,Brooks RA,Bulte JW,Gordon D,Aisen P

更新日期：1998-09-01 00:00:00

abstract：:The reaction between reduced Pseudomonas cytochrome c551 and cytochrome oxidase with two inorganic metal complexes, Co(phen)3(3+) and Mn(CyDTA)(H2O)-, has been followed by stopped-flow spectrophotometry. The electron transfer to cytochrome c551 by both reactants is a simple process, characterized by the following seco...

journal_title：Journal of inorganic biochemistry

authors： Tordi MG,Silvestrini MC,Adzamli K,Brunori M

更新日期：1987-07-01 00:00:00

abstract：:The stoichiometry and stability constants of the Ga(III) complexes of 8-hydroxyquinoline (HQ), 8-hydroxyquinoline-5-sulfonate (HQS), maltol, thiomaltol, allomaltol and thioallomaltol were determined by means of pH-potentiometry, UV-vis spectrophotometry, spectrofluorometry and (1)H NMR spectroscopy in aqueous solution...

journal_title：Journal of inorganic biochemistry

authors： Enyedy ÉA,Dömötör O,Varga E,Kiss T,Trondl R,Hartinger CG,Keppler BK

更新日期：2012-12-01 00:00:00

abstract：:Cytochrome c(551) from Pseudomonas aeruginosa is a monomeric redox protein of 82 amino-acid residues, involved in dissimilative denitrification as the physiological electron donor of cd(1) nitrite reductase. The distribution of charged residues on the surface of c(551) is very anisotropic: one side is richer in acidic...

journal_title：Journal of inorganic biochemistry

authors： Cutruzzolà F,Arese M,Ranghino G,van Pouderoyen G,Canters G,Brunori M

更新日期：2002-02-01 00:00:00

abstract：:A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) co...

journal_title：Journal of inorganic biochemistry

authors： Barbosa ASL,Guedes JS,da Silva DR,Meneghetti SMP,Meneghetti MR,da Silva AE,de Araujo MV,Alexandre-Moreira MS,de Aquino TM,de Siqueira Junior JP,de Araújo RSA,da Cruz RMD,Mendonça-Junior FJB

更新日期：2018-03-01 00:00:00

abstract：:Tiopronin, a synthetic thiol-containing drug being used in treatments of cystinuria and certain types of rare arthritis, is also a hepatoprotective and a detoxifying agent. Many analytical methods have been developed based on its redox chemistry with metal ions/complexes, but the kinetic and mechanistic aspects are po...

journal_title：Journal of inorganic biochemistry

authors： Huo S,Shi H,Liu D,Shen S,Zhang J,Song C,Shi T

更新日期：2013-08-01 00:00:00

abstract：:Bioorganometallic ferrocene-dipeptide conjugates with the Ala-Pro-cysteamine chain, Fc-L-Ala-L-Pro-NHCH2CH2SH (2) and Fc-L-Ala-D-Pro-NHCH2CH2SH (4) (Fc=ferrocenoyl), were prepared by the reduction of the ferrocene-dipeptide conjugates, Fc-L-Ala-L-Pro-cystamine-L-Pro-L-Ala-Fc (1) or Fc-L-Ala-D-Pro-cystamine-D-Pro-L-Ala...

journal_title：Journal of inorganic biochemistry

authors： Moriuchi T,Nishiyama T,Tayano Y,Hirao T

更新日期：2017-12-01 00:00:00

abstract：:Iron(III) complexes [Fe(L)(2)]Cl (1-3), where L is monoanionic N-salicylidene-arginine (sal-argH for 1), hydroxynaphthylidene-arginine (nap-argH for 2) and N-salicylidene-lysine (sal-lysH for 3), were prepared and their DNA binding and photo-induced DNA cleavage activity studied. Complex 3 as its hexafluorophosphate s...

journal_title：Journal of inorganic biochemistry

authors： Ameerunisha Begum MS,Saha S,Nethaji M,Chakravarty AR

更新日期：2010-04-01 00:00:00

abstract：:Cystine, selenocytsine, and several analogs were reduced by dithiothreitol (DTT), beta-mercaptoethanol (ME) and sodium borohydride (NaBH4). DTT was the most effective; DTT to cystine ratios from 10 to 80 were equally effective. With selenocysteine, however, absorption was considerably reduced at all ratios. Selenocyst...

journal_title：Journal of inorganic biochemistry

authors： Burnell JN,Karle JA,Shrift A

更新日期：1980-07-01 00:00:00