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Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.

Abstract：

:In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

MacDonald TC,Nehzati S,Sylvain NJ,James AK,Korbas M,Caine S,Pickering IJ,George GN,Krone PH

doi

10.1016/j.jinorgbio.2015.07.003

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

10-7

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(15)30030-1

journal_volume

151

pub_type

杂志文章

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