Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines.

abstract：:In an effort to examine the relative position of a hairpin loop in New Delhi metallo-β-lactamase, NDM-1, during catalysis, rapid freeze quench double electron electron resonance (RFQ-DEER) spectroscopy was used. A doubly-labeled mutant of NDM-1, which had one spin label on the invariant loop at position 69 and another...

journal_title：Journal of inorganic biochemistry

authors： Aitha M,Moller AJ,Sahu ID,Horitani M,Tierney DL,Crowder MW

更新日期：2016-03-01 00:00:00

abstract：:Insulin resistance is identified through numerous pathophysiological conditions, such as Diabetes mellitus II, obesity, hypertension and other metabolic syndromes. Enhancement of insulin action and\or its complete replacement by insulin-enhancing or insulin-mimetic agents seems to improve treatment of metabolic diseas...

journal_title：Journal of inorganic biochemistry

authors： Tsave O,Yavropoulou MP,Kafantari M,Gabriel C,Yovos JG,Salifoglou A

更新日期：2016-10-01 00:00:00

abstract：:The visible and ultraviolet circular dichroic spectra resulting from the interaction of bovine alpha-lactalbumin with successive Cu(II) ions have been recorded under a variety of conditions. Analysis of the observed change-transfer and d-d band transitions can be made in terms of two kinds of binding sites: at a histi...

journal_title：Journal of inorganic biochemistry

authors： Tieghem E,Van Dael H,Van Cauwelaert F

更新日期：1991-05-01 00:00:00

abstract：:A photostable Ru(2,2-biquinoline)2(3-(2-pyridyl)-5-(4-carboxyphenyl)-1,2,4-triazolate) (Ru(biq)2(trzbenzCOOH)) complex that exhibits near-infrared (NIR) emission centred at 786 nm is reported. The parent complex was conjugated via amide coupling to a cell-penetrating peptide sequence octa-arginine (R8), and two signal...

journal_title：Journal of inorganic biochemistry

authors： Cullinane D,Gkika KS,Byrne A,Keyes TE

更新日期：2020-06-01 00:00:00

abstract：:The kinetics of reduction of a peroxidatically active intermediate (formed by reaction of deuteroferriheme with hydrogen peroxide) by phenol and a series of substituted phenols have been studied by stopped-flow spectrophotometry. The complex effects of varying heme concentration have been interpreted in terms of the f...

journal_title：Journal of inorganic biochemistry

authors： Jones P,Mantle D,Wilson I

更新日期：1982-12-01 00:00:00

abstract：:In heme peroxidases, a distal His residue plays an essential role in the initial two electron oxidation of resting state enzyme to compound I by hydrogen peroxide. A distal Arg residue assists in this process. The contributions of the charge, H-bonding capacity, size, and mobility of this Arg residue to Coprinus ciner...

journal_title：Journal of inorganic biochemistry

authors： Schiødt CB,Veitch NC,Welinder KG

更新日期：2007-02-01 00:00:00

abstract：:Due to the broad spectrum of biological activities of flavonoids, their target molecules in the cell are intensively studied. We examined the interactions of the flavonoid quercetin (Q) and its lanthanum complex (QLa(3+)) with very recently isolated plant viral satellite (sat) dsRNA. Comparison of the cumulative bindi...

journal_title：Journal of inorganic biochemistry

authors： Rusak G,Piantanida I,Bretschneider S,Ludwig-Müller J

更新日期：2009-12-01 00:00:00

abstract：:The synthesis and characterization of four palladium(II) complexes with substituted salicylaldehydes (X-saloH) having the general formula [Pd(X-salo)2] was undertaken. The complexes are formulated as [Pd(3-OCH3-salo)2] 1, [Pd(5-NO2-salo)2] 2, [Pd(5-Cl-salo)2] 3, and [Pd(5-Br-salo)2] 4. The structure of complex 1 was v...

journal_title：Journal of inorganic biochemistry

authors： Zianna A,Geromichalos GD,Hatzidimitriou AG,Coutouli-Argyropoulou E,Lalia-Kantouri M,Psomas G

更新日期：2019-05-01 00:00:00

abstract：:Three biotinylated platinum(IV) complexes (1-3) were designed and synthesized. The resulting platinum(IV) complexes exhibited effective cytotoxicity against the tested cancer cell lines, especially complex 1, which was 2.0-9.6-fold more potent than cisplatin. These complexes were found to be rapidly reduced to their a...

journal_title：Journal of inorganic biochemistry

authors： Zhao J,Hua W,Xu G,Gou S

更新日期：2017-11-01 00:00:00

abstract：:HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1α. Prior s...

journal_title：Journal of inorganic biochemistry

authors： Pektas S,Knapp MJ

更新日期：2013-09-01 00:00:00

abstract：:Raman spectra were acquired on ox femur samples treated with hydrazine to remove the organic components of bone. A large increase in the signal-noise ratio of the mineral spectrum resulted from the exposure of the mineral surface and the removal of fluorescent components of the organic matrix. The effect of hydrazine ...

journal_title：Journal of inorganic biochemistry

authors： Walters MA,Leung YC,Blumenthal NC,LeGeros RZ,Konsker KA

更新日期：1990-07-01 00:00:00

abstract：:Since the 1970s, the biological role of vanadium compounds has been discussed as insulin-mimetic or insulin-enhancer agents. The action of vanadium compounds has been investigated to determine how they influence the insulin signaling pathway. Khan and coworkers proposed key proteins for the insulin pathway study, intr...

journal_title：Journal of inorganic biochemistry

authors： Treviño S,Diaz A

更新日期：2020-07-01 00:00:00

abstract：:The first reported homogenous rare earth curcumin (HCurc; ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione)) complexes with the formula ML3, where M(3+) is Eu(III), Gd(III) or Lu(III), were synthesized and characterized by mass spectrometry, infrared spectroscopy and, in the case of the lutetium co...

journal_title：Journal of inorganic biochemistry

authors： Mawani Y,Orvig C

更新日期：2014-03-01 00:00:00

abstract：:An array of poly- and mononuclear complexes of Pt(II) with polypyridyl ligands is reported. The framework complexes [(PtCl(2))(2)(bpp)(2)(micro-PtCl(2))](H(2)O)(2) [bpp=2,3-bis(2-pyridyl)pyrazine], [PtCl(2)(micro-tptz)PtClNCPh]Cl [tptz=2,4,6-tris(2-pyridyl)-1,3,5-triazine], and mononuclear PtCl(2)(NH(2)dpt) [NH(2)dpt=...

journal_title：Journal of inorganic biochemistry

authors： Rubino S,Portanova P,Albanese A,Calvaruso G,Orecchio S,Fontana G,Stocco GC

更新日期：2007-10-01 00:00:00

abstract：:Antitumor antibiotic bleomycin can bind to and degrade DNA, both in vivo and in vitro. This DNA damaging property in vitro can be related to its ability to chelate ferrous ions under aerobic conditions leading to the formation of "active oxygens," which are thought to be directly responsible for the damage. At present...

journal_title：Journal of inorganic biochemistry

authors： Gutteridge JM,Shute DJ

更新日期：1981-12-01 00:00:00

abstract：:The stoichiometry of dioxygen uptake of Co complexes with 4',5'-bis-(5-chloro-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1a), 4',5'-bis(2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1b), 4',5'-bis-(5-methoxy-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1c), 4',5'-bis-(5-chloro-2-hydroxyphenylmethyliden...

journal_title：Journal of inorganic biochemistry

authors： Sun B,Chen J,Hu J,Li X

更新日期：2006-08-01 00:00:00

abstract：:Vanadium has well-documented blood-glucose-lowering properties both in vitro and in vivo. The design of new oxovanadium(IV) coordination compounds, intended for use as insulin-enhancing agents in the treatment of diabetes mellitus, can potentially benefit from a synergistic approach, in which the whole complex has mor...

journal_title：Journal of inorganic biochemistry

authors： Woo LC,Yuen VG,Thompson KH,McNeill JH,Orvig C

更新日期：1999-09-30 00:00:00

abstract：:Nitroxyl (HNO) has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during decomposition limits the use of AS requiring other HNO sources. Acyloxy nitroso c...

journal_title：Journal of inorganic biochemistry

authors： DuMond JF,Wright MW,King SB

更新日期：2013-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) generates superoxide, particularly at sub-optimal l-arginine (l-Arg) substrate concentrations. Heat shock protein 90 (Hsp90) was reported to inhibit superoxide generation from nNOS protein. However, commercially available Hsp90 product from bovine brain tissues with unspecified Hs...

journal_title：Journal of inorganic biochemistry

authors： Zheng H,Weaver JM,Feng C

更新日期：2021-01-01 00:00:00

abstract：:To characterize heme oxygenase with a selenocysteine (SeCys) as the proximal iron ligand, we have expressed truncated human heme oxygenase-1 (hHO-1) His25Cys, in which Cys-25 is the only cysteine, in the Escherichia coli cysteine auxotroph strain BL21(DE3)cys. Selenocysteine incorporation into the protein was demonstr...

journal_title：Journal of inorganic biochemistry

authors： Jiang Y,Trnka MJ,Medzihradszky KF,Ouellet H,Wang Y,Ortiz de Montellano PR

更新日期：2009-03-01 00:00:00

abstract：:A new ligand, N,N'-dibenzylethane-1,2-diamine (L) and its four transition metal(II) complexes, ML(2)(OAc)(2).2H(2)O (M=Cu, Ni, Zn, Co), have been synthesized and characterized by elemental analysis, mass spectra, molar conductivity, NMR and IR. Moreover, the crystals structure of Cu(II) and Ni(II) complexes characteri...

journal_title：Journal of inorganic biochemistry

authors： Wu SS,Yuan WB,Wang HY,Zhang Q,Liu M,Yu KB

更新日期：2008-11-01 00:00:00

abstract：:Transition metal homeostasis is necessary to sustain life. First row transition metals act as cofactors within the cell, performing vital functions ranging from DNA repair to respiration. However, intracellular metal concentrations exceeding physiological requirements may be toxic. In E. coli, the YqjH flavoprotein is...

journal_title：Journal of inorganic biochemistry

authors： Blahut M,Dzul S,Wang S,Kandegedara A,Grossoehme NE,Stemmler T,Outten FW

更新日期：2018-07-01 00:00:00

abstract：:The reactivities of copper(II) complexes with histidine-containing oligopeptides towards active oxygen species such as hydrogen peroxide (H2O2) and superoxide ion (O2-) were investigated by electron spin resonance (ESR)-spin trapping and thiobarbituric acid (TBA) methods. At physiological pH values, Cu(II) complexes w...

journal_title：Journal of inorganic biochemistry

authors： Ueda J,Ozawa T,Miyazaki M,Fujiwara Y

更新日期：1994-08-01 00:00:00

abstract：:Vanadate has been recognized as a specific and potent phosphatase inhibitor since its structure is similar to that of phosphate. In this study, we measured the inhibition of glutathione S-transferase-tagged protein tyrosine phosphatase 1B (GST-PTP1B) and alkaline phosphatase (ALP) by the insulin enhancing compounds, b...

journal_title：Journal of inorganic biochemistry

authors： Li M,Ding W,Baruah B,Crans DC,Wang R

更新日期：2008-10-01 00:00:00

abstract：:Aiming at obtaining new copper complexes with good cytotoxicity against cancer cells, triphenylphosphine (TPP) was introduced to obtain insight into the influence of the co-ligands. In this paper, two copper complexes, Cu(2-pbmq)(CH3OH)Br2 (1) and [Cu(2-pbmq)(TPP)Br]2 (2) were designed, synthesized, and characterized ...

journal_title：Journal of inorganic biochemistry

authors： Li S,Zhao J,Guo Y,Mei Y,Yuan B,Gan N,Zhang J,Hu J,Hou H

更新日期：2020-09-01 00:00:00

abstract：:Biological studies on [Fe(L)2](NO3).0.5H2O (1), [Fe(L)2][PF6] (2), [Co(L)2](NCS) (3), [Ni(HL)2]Cl2.3H2O (4) and Cu(L)(NO3) (5), where HL=C7H8N4S, pyridine-2-carbaldehyde thiosemicarbazone, have been carried out. The crystal structure of compound 3 has been solved. It consists of discrete monomeric cationic entities co...

journal_title：Journal of inorganic biochemistry

authors： García-Tojal J,García-Orad A,Díaz AA,Serra JL,Urtiaga MK,Arriortua MI,Rojo T

更新日期：2001-04-01 00:00:00

abstract：:Ten new vanadocene complexes bearing N,N'-chelating ligands were prepared, characterized, and their cytotoxicity toward a panel of cancer cells was measured. Structures of four vanadocene compounds were determined by single crystal X-ray diffraction analysis. Complexes containing 1,2-bis(phenylimino)acenaphthene (bian...

journal_title：Journal of inorganic biochemistry

authors： Melounková L,Machálková A,Havelek R,Honzíček J,Řezáčová M,Císařová I,Peterová E,Vinklárek J

更新日期：2019-06-01 00:00:00

abstract：:Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold drugs seem to be mediated, mainly, by ...

journal_title：Journal of inorganic biochemistry

authors： Darabi F,Marzo T,Massai L,Scaletti F,Michelucci E,Messori L

更新日期：2015-08-01 00:00:00

abstract：:An iron porphycene, a structural isomer of iron porphyrin, with trifluoromethyl groups at the peripheral position of the framework was incorporated into sperm whale apomyoglobin. The prepared myoglobin shows the higher O(2) affinity than the native protein. However, the oxygen affinity of the reconstituted myoglobin i...

journal_title：Journal of inorganic biochemistry

authors： Matsuo T,Ito K,Nakashima Y,Hisaeda Y,Hayashi T

更新日期：2008-02-01 00:00:00

abstract：:Transition metals, such as Cu(+2), Mn(+2), and Co(+2), have been seen to catalyze the bicarbonate enhanced oxidation of a variety of substrates by H(2)O(2). In several of these cases it has been demonstrated that CO(2), rather than bicarbonate, is the enhancing species. Mechanisms that are in accord with the data invo...

journal_title：Journal of inorganic biochemistry

authors： Liochev SI,Fridovich I

更新日期：2006-04-01 00:00:00