当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Improved separation of the curcuminoids, syntheses of their rare earth complexes, and studies of potential antiosteoporotic activity.

Improved separation of the curcuminoids, syntheses of their rare earth complexes, and studies of potential antiosteoporotic activity.

Abstract：

:The first reported homogenous rare earth curcumin (HCurc; ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione)) complexes with the formula ML3, where M(3+) is Eu(III), Gd(III) or Lu(III), were synthesized and characterized by mass spectrometry, infrared spectroscopy and, in the case of the lutetium complex, (1)H NMR spectroscopy. Most importantly an improved separation of the three curcuminoids, HCurc, HDMC ((1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione) and HBDMC ((1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione) was realized using a combination of normal-phase column and phosphate-impregnated preparative-thin layer chromatographies. The toxicities of the metal curcumin complexes and ligands were investigated in MG-63 cells, an osteoblast-like cell line, for potential activity as antiosteoporotic agents.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Mawani Y,Orvig C

doi

10.1016/j.jinorgbio.2013.12.004

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

52-8

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(13)00324-3

journal_volume

132

pub_type

杂志文章

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