Carbonic anhydrase inhibitors. Part 11. Coordination compounds of heterocyclic sulfonamides with lanthanides are potent inhibitors of isozymes I and II.

abstract：:Seven ferrocenyl naphthalene diimide (FND) ligands were synthesized. Each had a higher affinity for tetraplex DNA than for either single- or double-stranded DNA. The FND binding affinities were >105M-1 in 0.10M AcOH-AcONa or AcOH-AcOK (pH5.5) containing 0.10M NaCl or KCl. The FNDs with the highest binding affinities f...

journal_title：Journal of inorganic biochemistry

authors： Sato S,Takenaka S

更新日期：2017-02-01 00:00:00

abstract：:Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of...

journal_title：Journal of inorganic biochemistry

authors： Crisponi G,Nurchi VM,Pivetta T,Gałezowska J,Gumienna-Kontecka E,Bailly T,Burgada R,Kozłowski H

更新日期：2008-07-01 00:00:00

abstract：:To identify regulatory elements in the rat selenoprotein W (SeW) promoter, 2090, 1265, 741, and 404 base pair truncations of genomic DNA lying immediately upstream of the SeW coding sequence were cloned into a luciferase reporter vector (pGL3-Basic from Promega, Madison, WI, USA). 3656 and 406 base pair mouse SeW prom...

journal_title：Journal of inorganic biochemistry

authors： Hooven LA,Vorachek WR,Bauman AB,Butler JA,Ream LW,Whanger PD

更新日期：2005-10-01 00:00:00

abstract：:The binding of acetazolamide, p-fluorobenzensulfonamide, p-toluenesulfonamide, and sulfanilamide to nickel(II)-substituted carbonic anhydrase II has been studied by 1H NMR and electronic absorption spectroscopies. These inhibitors bind to the metal ion forming 1:1 complexes and their affinity constants were determined...

journal_title：Journal of inorganic biochemistry

authors： Moratal JM,Martinez-Ferrer MJ,Jiménez HR,Donaire A,Castells J,Salgado J

更新日期：1992-03-01 00:00:00

abstract：:We have studied the electron paramagnetic resonance (epr) spectra of complexes of apo-yeast enolase with 65Cu+2 in the presence and absence of substrate and magnesium ion. An unusual epr spectrum with large g parallel, large g and A rhombicity and very narrow line-widths (10 G) is seen for the first two 65Cu+2 bound i...

journal_title：Journal of inorganic biochemistry

authors： Dickinson LC,Rose SL,Westhead EW

更新日期：1980-12-01 00:00:00

abstract：:Aluminum, the most abundant neurotoxic metal in our biosphere, has been implicated in the etiology of several neurodegenerative disorders including Alzheimer's disease (AD). To further understand aluminum's influence on gene expression, we examined total messenger RNA levels in untransformed human neural cells exposed...

journal_title：Journal of inorganic biochemistry

authors： Lukiw WJ,Percy ME,Kruck TP

更新日期：2005-09-01 00:00:00

abstract：:Catalase (CAT) and myeloperoxiase (MPO) are heme-containing enzymes that have attracted attention for their role in the etiology of numerous respiratory disorders such as cystic fibrosis, bronchial asthma, and acute hypoxemic respiratory failure. However, information regarding the interrelationship and competition bet...

journal_title：Journal of inorganic biochemistry

authors： Ali I,Khan SN,Chatzicharalampous C,Bai D,Abu-Soud HM

更新日期：2019-08-01 00:00:00

abstract：:Extended x-ray absorption fine structure (EXAFS) spectra have been recorded at the Cu edge and Zn edge in native yeast superoxide dismutase and at the Cu edge and Cd edge in the yeast superoxide dismutase derivative, where Zn has been substituted with Cd. Two different metal ligand distances in the range 1.9-2.0 A and...

journal_title：Journal of inorganic biochemistry

authors： Phillips JC,Bauer R,Dunbar J,Johansen JT

更新日期：1984-11-01 00:00:00

abstract：:Vanadium compounds exert various insulin-mimetic and anti-diabetic effects both in vitro and in vivo. Vanadium(III, IV, V)-chlorodipicolinate (Vdipic-Cl) compounds, including H[V(III)(dipic-Cl)2]·5H2O (V3dipic-Cl), V(IV)O(dipic-Cl)(H2O)2 (V4dipic-Cl) and K[V(V)O2(dipic-Cl)] (V5dipic-Cl), were synthesized with the indi...

journal_title：Journal of inorganic biochemistry

authors： Xie M,Chen D,Zhang F,Willsky GR,Crans DC,Ding W

更新日期：2014-07-01 00:00:00

abstract：:Due to the broad spectrum of biological activities of flavonoids, their target molecules in the cell are intensively studied. We examined the interactions of the flavonoid quercetin (Q) and its lanthanum complex (QLa(3+)) with very recently isolated plant viral satellite (sat) dsRNA. Comparison of the cumulative bindi...

journal_title：Journal of inorganic biochemistry

authors： Rusak G,Piantanida I,Bretschneider S,Ludwig-Müller J

更新日期：2009-12-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) generates superoxide, particularly at sub-optimal l-arginine (l-Arg) substrate concentrations. Heat shock protein 90 (Hsp90) was reported to inhibit superoxide generation from nNOS protein. However, commercially available Hsp90 product from bovine brain tissues with unspecified Hs...

journal_title：Journal of inorganic biochemistry

authors： Zheng H,Weaver JM,Feng C

更新日期：2021-01-01 00:00:00

abstract：:The redox active iron-sulfur center of bovine adrenodoxin is coordinated by four cysteine residues in positions 46, 52, 55 and 92 and is covered by a loop containing the residues Glu-47, Gly-48, Thr-49, Leu-50 and Ala-51. In plant-type [2Fe-2S] ferredoxins, the corresponding loop consists of only four amino acids. The...

journal_title：Journal of inorganic biochemistry

authors： Zöllner A,Hannemann F,Lisurek M,Bernhardt R

更新日期：2002-09-20 00:00:00

abstract：:The prostate gland of humans and other animals accumulates a level of zinc that is 3-10 times greater than that found in other tissues. Associated with this ability to accumulate zinc is a rapid zinc uptake process in human prostate cells, which we previously identified as the hZIP1 zinc transporter. We now provide ad...

journal_title：Journal of inorganic biochemistry

authors： Franklin RB,Ma J,Zou J,Guan Z,Kukoyi BI,Feng P,Costello LC

更新日期：2003-08-01 00:00:00

abstract：:A series of new platinum(II) and platinum(IV) adducts of type [P(II)(cis-1,4-DACH)LCl]NO(3,) where cis-1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt(IV)(cis-1,4-DACH)Ltrans-(X)(2)Cl]NO(3), (where Y=hydroxo or acetato), were synthes...

journal_title：Journal of inorganic biochemistry

authors： Ali MS,Khokhar AR

更新日期：2003-09-01 00:00:00

abstract：:Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance for all three aspects of cellular iron metabolism at the level ...

journal_title：Journal of inorganic biochemistry

authors： Kühn LC,Hentze MW

更新日期：1992-08-15 00:00:00

abstract：:The inhibitory effect of Cu2+, Mn2+, Co2+, and I- on naproxen-induced photohemolysis was investigated. In order to better understand this effect, these ions were also tested for lipid peroxidation and protein crosslinking, which are among the main processes involved in erythrocyte membrane damage. The overall results ...

journal_title：Journal of inorganic biochemistry

authors： Giuffrida S,De Guidi G,Miano P,Sortino S,Condorelli G,Costanzo LL

更新日期：1996-09-01 00:00:00

abstract：:The study of the reactivity of three 1-(2-dimethylaminoethyl)-1H-pyrazole derivatives of general formula [1-(CH(2))(2)NMe(2)}-3,5-R(2)-pzol] {where pzol represents pyrazole and R=H (1a), Me (1b) or Ph (1c)} with [MCl(2)(DMSO)(2)] (M=Pt or Pd) under different experimental conditions allowed us to isolate and characteri...

journal_title：Journal of inorganic biochemistry

authors： Quirante J,Ruiz D,Gonzalez A,López C,Cascante M,Cortés R,Messeguer R,Calvis C,Baldomà L,Pascual A,Guérardel Y,Pradines B,Font-Bardía M,Calvet T,Biot C

更新日期：2011-12-01 00:00:00

abstract：:Chromomycin A(3) (CHR) and mithramycin (MTR), members of the aureolic acid anticancer antibiotics, supposedly act by inhibiting transcription via reversible association with DNA. The complex(es) with bivalent cation such as Mg(2+) and Zn(2+) is (are) the DNA-binding ligand(s). In this paper, we report a detailed study...

journal_title：Journal of inorganic biochemistry

authors： Devi PG,Pal S,Banerjee R,Dasgupta D

更新日期：2007-01-01 00:00:00

abstract：:The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra. The crystal structures of the compound [ZnCl(2)(3TTSCH)...

journal_title：Journal of inorganic biochemistry

authors： Alomar K,Landreau A,Kempf M,Khan MA,Allain M,Bouet G

更新日期：2010-04-01 00:00:00

abstract：:Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation. As a result of the amphiphilic properties of these siderophores it is difficult to study siderophore-mediated uptake of iron, because the a...

journal_title：Journal of inorganic biochemistry

authors： Martinez JS,Butler A

更新日期：2007-11-01 00:00:00

abstract：:The copper(II)-5-fluorosalicylic acid system was investigated in water and 50 v/v% water-methanol mixture by pH potentiometry combined with UV-vis spectrophotometry, and by the two-dimensional ESR simulation method, respectively. The data revealed that the stable paramagnetic mono- and bis(salicylato) copper(II) compl...

journal_title：Journal of inorganic biochemistry

authors： Szabó-Plánka T,Gyurcsik B,Nagy NV,Rockenbauer A,Sípos R,Sima J,Melník M

更新日期：2008-01-01 00:00:00

abstract：:The polymer-supported oxidovanadium(IV) complex PS-[V(IV)O(sal-dahp)] (2) (PS=chloromethylated polystyrene crosslinked with 5% divinylbenzene, and H3sal-dahp=dibasic pentadentate ligand derived from salicylaldehyde and 1,3-diamino-2-hydroxypropane) was prepared from the corresponding monomeric oxidovanadium(IV) comple...

journal_title：Journal of inorganic biochemistry

authors： Maurya MR,Chaudhary N,Avecilla F,Correia I

更新日期：2015-06-01 00:00:00

abstract：:Some DNA-binding experiments employing a selected number of novel dinuclear platinum complexes with the 4,4'-dipyrazolylmethane (dpzm) ligand are reported. A DNA-cleavage assay using Eco RI and Bam HI restriction endonucleases to probe the binding of the complexes at or near their unique restriction sequences of pUC9 ...

journal_title：Journal of inorganic biochemistry

authors： Broomhead JA,Rendina LM,Webster LK

更新日期：1993-02-15 00:00:00

abstract：:The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and the protein purified to homogeneity by ion exchange and hydrophobic interaction chromatography. The CYP121 gene encodes a cytochrome P450 enzyme (CYP121) that displays typical electronic abso...

journal_title：Journal of inorganic biochemistry

authors： McLean KJ,Cheesman MR,Rivers SL,Richmond A,Leys D,Chapman SK,Reid GA,Price NC,Kelly SM,Clarkson J,Smith WE,Munro AW

更新日期：2002-09-20 00:00:00

abstract：:The pH- and time-dependent reaction of the anticancer drug carboplatin, [Pt(cbdca-kappa(2)O,O')(NH(3))(2)] (cbdca=cyclobutane-1,1-dicarboxylate), with the tripeptides H-glyglymet-OH (glycylglycyl-L-methionine) and Ac-glyglymet-OH at 313 K was investigated by high-performance liquid chromatography, NMR and mass spectro...

journal_title：Journal of inorganic biochemistry

authors： Kleine M,Wolters D,Sheldrick WS

更新日期：2003-12-01 00:00:00

abstract：:The pH- and time-dependent reactions of the anticancer drug cisplatin, cis-[PtCl(2)(NH(3))(2)], with the peptides Ac-Gly-Met-Gly-OH, Ac-Ser-Met-OH and Ac-Met-His-OH (Gly=glycyl, Met=methionyl, Ser=seryl, His=histidyl) at 313 K have been investigated by high-performance liquid chromatography, nuclear magnetic resonance...

journal_title：Journal of inorganic biochemistry

authors： Manka S,Becker F,Hohage O,Sheldrick WS

更新日期：2004-11-01 00:00:00

abstract：:In spite of significant applications as starting materials for a variety of metallocorrole derivatives, free-base β-octabromo-meso-triarylcorroles continue to be viewed as inaccessible. The reasons range from the need for tedious column-chromatographic purification to limitations of the reductive demetallation protoco...

journal_title：Journal of inorganic biochemistry

authors： Capar J,Berg S,Thomas KE,Beavers CM,Gagnon KJ,Ghosh A

更新日期：2015-12-01 00:00:00

abstract：:Two new complexes [(Etdpa)MnCl(2)] and [(Adpa)Mn(Cl)(H(2)O)] (Etdpa = ethyl bis(2-pyridylmethyl)amino-2-propionate; Adpa = bis(2-pyridylmethyl)amino-2-propionic acid) were synthesized and characterized by spectral methods. The crystal structure of [(Etdpa)MnCl(2)] shows that the Mn(II) atom is coordinated by three N a...

journal_title：Journal of inorganic biochemistry

authors： Qiu-Yun C,Dong-Fang Z,Juan H,Wen-Jie G,Jing G

更新日期：2010-11-01 00:00:00

abstract：:The CuA center is a dinuclear Cu2S2(Cys) electron transfer center found in cytochrome c oxidase and nitrous oxide reductase. In a previous investigation of the equatorial histidine ligands' effect on the reduction potential, electron transfer and spectroscopic properties of the CuA center, His120 in the engineered CuA...

journal_title：Journal of inorganic biochemistry

authors： Berry SM,Wang X,Lu Y

更新日期：2000-01-15 00:00:00

abstract：:Aluminium chemistry has features in common with two other groups of elements: (1) divalent magnesium and calcium, and (2) trivalent chromium and iron. The essential differences between the first group and aluminium are explored and it is shown that the much higher acidity of aluminium makes it such a powerful competit...

journal_title：Journal of inorganic biochemistry

authors： Williams RJ

更新日期：1999-08-30 00:00:00