cis-1,4-diaminocyclohexane-Pt(II) and -(IV) adducts with DNA bases and nucleosides.

abstract：:Incubation of cytochrome c oxidase (CcO) in its resting state in saturated ammonium sulfate, at room temperature overnight, gave EPR signals characteristic of a single Cu(II) center. From the g// and A// values it is concluded that this is a square-planar type 2 copper center, and superhyperfine splitting shows the pr...

journal_title：Journal of inorganic biochemistry

authors： Pezeshk A,Torres J,Wilson MT,Symons MC

更新日期：2001-01-15 00:00:00

abstract：:The biochemical characterization of individual nitrergic (NO releasing) neurons is a non-trivial task both in vertebrate and invertebrate preparations. In spite of numerous efforts, there are limited data related to intracellular concentrations of essential metabolites involved in NO synthesis and degradation. This si...

journal_title：Journal of inorganic biochemistry

authors： Moroz LL,Dahlgren RL,Boudko D,Sweedler JV,Lovell P

更新日期：2005-04-01 00:00:00

abstract：:A dimeric copper complex of the unsubstituted pyridoxal thiosemicarbazone (H(2)L), [[Cu(HL)(OH(2))](2)]Cl(2).2H(2)O, previously tested on Friend murine cell lines has been recently resynthesized to evaluate its behavior on different murine and human leukemic cell lines and has been compared, in vitro and in vivo, with...

journal_title：Journal of inorganic biochemistry

authors： Belicchi Ferrari M,Bisceglie F,Pelosi G,Tarasconi P,Albertini R,Dall'Aglio PP,Pinelli S,Bergamo A,Sava G

更新日期：2004-02-01 00:00:00

abstract：:The Ce(IV)-mitoxantrone complex exhibits a higher lethality to Ehrlich ascites tumor cells than that of the free drug and shows stronger inhibition ability on the DNA synthesis of the tumor cells. Thus the Ce(IV)-mitoxantrone complex may become a more potent antitumor drug than mitoxantrone. The different interaction ...

journal_title：Journal of inorganic biochemistry

authors： Wang H,Yang P,Tian Y,Zhang Z,Zhao C

更新日期：1997-11-01 00:00:00

abstract：:Two-subunit SoxB-type cytochrome c oxidase in Bacillus stearothermophilus was over-produced, purified, and examined for its active site structures by electron paramagnetic resonance (EPR) and resonance Raman (RR) spectroscopies. This is cytochrome bo3 oxidase containing heme B at the low-spin heme site and heme O at t...

journal_title：Journal of inorganic biochemistry

authors： Uchida T,Tsubaki M,Kurokawa T,Hori H,Sakamoto J,Kitagawa T,Sone N

更新日期：2000-11-01 00:00:00

abstract：:L-Cysteinatogold(I) was prepared by the reaction of L-cysteine with KAuBr4 in acidic media and its solubility determined from pH 4 to 10. The solubility at pH 7.4 and 37 degrees C is 1 microM. In the presence of excess cysteine, the solubility increases because of formation of bis(L-cysteinato)gold(I). The equilibrium...

journal_title：Journal of inorganic biochemistry

authors： Shaw CF 3rd,Schmitz G,Thompson HO,Witkiewicz P

更新日期：1979-07-01 00:00:00

abstract：:A micro-electrochemical reaction cell was coupled to an electrospray mass spectrometer in order to track redox transformations for two representative medicinal gold compounds - i.e. [(2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S)(triethylphosphine)gold(I)] and [Au(bipydmb-H)(OH)][PF6] (where bipydmb-H is deprot...

journal_title：Journal of inorganic biochemistry

authors： Kupiec M,Ziółkowski R,Massai L,Messori L,Pawlak K

更新日期：2019-09-01 00:00:00

abstract：:Complex formation between D-penicillamine (Pen) and copper(II) ions has been studied under simulated physiological conditions in both the presence and absence of the blood plasma constituents albumin, alanine, histidine, and zinc(II). Chromatographic and uv/vis and electron spin resonance (esr) spectroscopic methods w...

journal_title：Journal of inorganic biochemistry

authors： Laurie SH,Prime DM

更新日期：1979-11-01 00:00:00

abstract：:Neuroglobin is a monomeric globin containing a six-coordinate heme b, expressed in the nervous system, which exerts an important neuroprotective role. In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of...

journal_title：Journal of inorganic biochemistry

authors： Bellei M,Bortolotti CA,Di Rocco G,Borsari M,Lancellotti L,Ranieri A,Sola M,Battistuzzi G

更新日期：2018-01-01 00:00:00

abstract：:Three amphiphilic antimony(V)-phthalocyanines have been synthesized by treating [Sb(R(4)Pc)(OH)(2)](+) salts in concentrated H(2)SO(4) and isolated as zwitter ions, [Sb(R(4)Pc)(SO(4)H)(SO(4))], where R(4)Pc denotes tetra-substituted phthalocyaninate; R(4)Pc=pc (R=H), tbpc (R=(t)Bu), and tObpc (R=O(n)Bu). Their solubil...

journal_title：Journal of inorganic biochemistry

authors： Isago H,Kagaya Y,Oyama Y,Fujita H,Sugimori T

更新日期：2012-06-01 00:00:00

abstract：:A number of oxidovanadium(IV) complexes have been reported to display anticancer activity. A theranostic approach, based on the simultaneous observation of both the effect of oxidovanadium(IV) complexes on cell viability and the disclosure of their intracellular fate, is possible by using oxidovanadium(IV) complexes f...

journal_title：Journal of inorganic biochemistry

authors： Lovisari M,Volpi G,Marabello D,Cadamuro S,Deagostino A,Diana E,Barge A,Gallicchio M,Boscaro V,Ghibaudi E

更新日期：2017-05-01 00:00:00

abstract：:Two macrocycles (1 and 2) are prepared that incorporate pendent groups in macrocycle 3 (3=1-oxa-4,7,10-triazacyclododecane) with the goal of studying the effect of these pendent groups on metal ion complexation, solution chemistry and catalysis. Zn(1) contains a macrocyclic ligand with a pendent acridine group and Zn(...

journal_title：Journal of inorganic biochemistry

authors： Rossiter CS,Mathews RA,Morrow JR

更新日期：2007-06-01 00:00:00

abstract：:Series of dinuclear species [Ru(2)(L)(2)(LH)(2)-mu-S(2)Cl(2)], [Ru(2)(L)(2)(LH)(4)-mu-Se(2)Cl(2)] (L=L(1)H and L(3)H) and [Ru(2)(L(2))(2)(L(2)H)-mu-Se(2)Cl(2)].2H(2)O, where L(1)H, L(2)H and L(3)H represent for 2-mercapto-5-phenyl-1,3,4-oxadiazole, 2-mercapto-benzimidazole and 2-mercapto-benzothiazole, respectively, h...

journal_title：Journal of inorganic biochemistry

authors： Mishra L,Vilaplana R,Singh VK,Yadaw AK,González-Vilchez F

更新日期：2001-09-01 00:00:00

abstract：:Lactoferrin (Lf) is a mammalian iron binding protein present in external secretions and in polymorphonuclear leukocytes. Its role in host defense mechanisms related to the non-immune defense system has been definitively established. Lf has two identical iron-binding sites, far from each other (44.3 A) and magnetically...

journal_title：Journal of inorganic biochemistry

authors： Fasano M,Fanali G,Polticelli F,Ascenzi P,Antonini G

更新日期：2004-08-01 00:00:00

abstract：:Antitumor antibiotic bleomycin can bind to and degrade DNA, both in vivo and in vitro. This DNA damaging property in vitro can be related to its ability to chelate ferrous ions under aerobic conditions leading to the formation of "active oxygens," which are thought to be directly responsible for the damage. At present...

journal_title：Journal of inorganic biochemistry

authors： Gutteridge JM,Shute DJ

更新日期：1981-12-01 00:00:00

abstract：:Methanobactins are copper-binding ligands produced by aerobic methanotrophic microorganisms. A quantitative understanding of their potential role in methanotrophic copper acquisition requires the investigation of their copper complexes under relevant pH conditions. In this study, a chemical speciation model describing...

journal_title：Journal of inorganic biochemistry

authors： Pesch ML,Christl I,Hoffmann M,Kraemer SM,Kretzschmar R

更新日期：2012-11-01 00:00:00

abstract：:Gold nanorods (GNRs) are important platforms for biosensing and drug delivery. As for most nanomaterials, appropriate coatings such as polyethylene glycol (PEG) are needed to stabilize GNRs within biological fluids. We show here that the interactions of GNRs with proteins can be finely modulated through surface modifi...

journal_title：Journal of inorganic biochemistry

authors： Scaletti F,Feis A,Centi S,Pini R,Rotello VM,Messori L

更新日期：2015-09-01 00:00:00

abstract：:A series of new copper (II) complexes with 2-methyl-3-amino(3H)-quinazolin-4-one (MAQ) and various anions (Cl-, Br-, ClO(-)4, NO(-)3, SCN-, and SO(2-)4 was prepared. Their structures and properties were characterized by elemental analysis, IR, UV-Vis and ESR spectroscopy, molar conductivity, and magnetic moment measur...

journal_title：Journal of inorganic biochemistry

authors： Ramadan AM

更新日期：1997-02-15 00:00:00

abstract：:The synthesis of the Co(III) porphyrin octapeptide N-acetyl-Co(III) microperoxidase-8 (NAcCoMP8) is described. NAcCoMP8 provides a means of comparing and contrasting the chemistry of Co(III) porphyrins and corrins to assess the influence of the macrocycle. Log K values, and ΔH and ΔS, for the coordination of anionic (...

journal_title：Journal of inorganic biochemistry

authors： Mathura S,Sannasy D,de Sousa AS,Perry CB,Navizet I,Marques HM

更新日期：2013-06-01 00:00:00

abstract：:A series of iminopyridine complexes of platinum(II), bearing a flexible diethereal, aryl terminated residue, where the size of aryl group is varied from phenyl to 9-anthracenyl, was synthesized. The new complexes are soluble and stable in DMSO/H2O mixtures. Besides the metal center, aryl groups are available for furth...

journal_title：Journal of inorganic biochemistry

authors： Bondi R,Dalla Via L,Hyeraci M,Pagot G,Labella L,Marchetti F,Samaritani S

更新日期：2020-12-15 00:00:00

abstract：:The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins contain Cu(I) and/or Cu(II) binding sites, with the family that binds Cu(II) only the most prevalent, based on sequence analyses. Here we present three crystal structures of the CopC protein ...

journal_title：Journal of inorganic biochemistry

authors： Udagedara SR,Wijekoon CJK,Xiao Z,Wedd AG,Maher MJ

更新日期：2019-06-01 00:00:00

abstract：:Bis[platinum(II)] [Cl2Pt(LL)PtCl2] complexes 2,5 and 8 with chiral non-racemic ligands: 1a-c (LL = (R,R), (S,S) and (R,S) N,N'-bis(3,4-diaminobutyl)hexanediamide); 4a,b (LL = (R,R) and (S,S) N,N'-bis[3,4-bis(diaminobutyl)] urea); 7a-d (LL' = (R,R), (S,S), (R,S) and (S,R) 4,5-diamino-N-(3,4-diaminobutyl) pentanamide) a...

journal_title：Journal of inorganic biochemistry

authors： Büning H,Altman J,Zorbas H,Beck W

更新日期：1999-07-15 00:00:00

abstract：:Vanadium compounds are promising anti-diabetic agents. However, reducing the metal toxicity while keeping/improving the hypoglycemic effect is still a big challenge towards the success of anti-diabetic vanadium drugs. To improve the therapeutic potency using the anti-oxidative strategy, we synthesized new N,N-dimethyl...

journal_title：Journal of inorganic biochemistry

authors： Niu X,Yang J,Yang X

更新日期：2017-12-01 00:00:00

abstract：:Calcium functions as a secondary messenger within the cytosols of eukaryotes. This serves as a reference point to evaluate three related questions:Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction. 1...

journal_title：Journal of inorganic biochemistry

authors： Permyakov EA,Kretsinger RH

更新日期：2009-01-01 00:00:00

abstract：:An iron porphycene, a structural isomer of iron porphyrin, with trifluoromethyl groups at the peripheral position of the framework was incorporated into sperm whale apomyoglobin. The prepared myoglobin shows the higher O(2) affinity than the native protein. However, the oxygen affinity of the reconstituted myoglobin i...

journal_title：Journal of inorganic biochemistry

authors： Matsuo T,Ito K,Nakashima Y,Hisaeda Y,Hayashi T

更新日期：2008-02-01 00:00:00

abstract：:[PtMe3(Me2CO)3]BF4 (1) reacts in acetone with 1,2,3,4-tetraacetyl-beta-D-glucopyranose (C2), pentaacetyl-alpha-D-glucopyranose (C3), pentaacetyl-beta-D-mannopyranose (C4) and pentaacetyl-beta-D-galactopyranose (C5) to give trimethyl(carbohydrate)platinum tetrafluoroborate complexes [PtMe3L]BF4 (2-5) (2, L=C2; 3, L=C3;...

journal_title：Journal of inorganic biochemistry

authors： Junicke H,Kluge R,Steinborn D

更新日期：2000-07-15 00:00:00

abstract：:The synthesis, physico-chemical characterization and cytotoxicity against five human tumoral cell lines (THP-1, U937, Molt-4, Colo205 and H460) of three new cobalt(II) coordination compounds are reported (i.e. Co(HL1)Cl (1), Co(HL2)Cl (2) and [Co(HL3)Cl]0.0.5 (CH3)2CHOH (3)). H2L2 (2-{[[2-hydroxy-3-(1-naphthyloxy)prop...

journal_title：Journal of inorganic biochemistry

authors： Morcelli SR,Bull ÉS,Terra WS,Moreira RO,Borges FV,Kanashiro MM,Bortoluzzi AJ,Maciel LL,de A Almeida JC,Júnior AH,Fernandes C

更新日期：2016-08-01 00:00:00

abstract：:The reaction of E-2-ferrocenylmethylidenetetralones and E,E-2,6-bis-(ferrocenylmethylidene)-cyclohexanone with 2-aminothiophenol proceed with high diastereoselectivity, forming the ~4.5:1 mixture of trans- and cis-isomers of polycyclic ferrocenylthiazepines, respectively. The reactions of E,E-2,5-bis-(ferrocenylmethyl...

journal_title：Journal of inorganic biochemistry

authors： Sánchez García JJ,Toledano-Magaña Y,Flores-Alamo M,Martínez-Klimova E,Galindo-Murillo R,Hernández-Ayala LF,Ortiz-Frade L,García-Ramos JC,Klimova EI

更新日期：2017-01-01 00:00:00

abstract：:The technique of comparative genomic hybridisation (CGH) has until recently been used to screen for common genomic abnormalities in fresh tumour material; it has identified previously unrecognised regions of amplification associated with poor prognosis subtypes of breast cancer and lymphoma. Our group has applied this...

journal_title：Journal of inorganic biochemistry

authors： Hiorns LR,Seckl MJ,Paradinas F,Sharp SY,Skelton LA,Brunstrom G,Newlands ES,Kelland LR,Leyland-Jones B

更新日期：1999-10-01 00:00:00

abstract：:Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance for all three aspects of cellular iron metabolism at the level ...

journal_title：Journal of inorganic biochemistry

authors： Kühn LC,Hentze MW

更新日期：1992-08-15 00:00:00