Cell signaling, beyond cytosolic calcium in eukaryotes.


:Calcium functions as a secondary messenger within the cytosols of eukaryotes. This serves as a reference point to evaluate three related questions:Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction. 1. Calcium, as well as cyclic AMP, also functions as a paracrine messenger; how specific and extensive is this use? 2. Calcium binding proteins and calcium extrusion mechanisms have been identified in prokaryotes; does it function as a messenger? 3. The concentrations of other divalent cations, especially zinc and magnesium, are well regulated and perturbations have specific physiological impacts; are these divalents involved in information transfer? Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction.


J Inorg Biochem


Permyakov EA,Kretsinger RH




Has Abstract


2009-01-01 00:00:00














  • Interaction of vanadium(IV) with human serum apo-transferrin.

    abstract::The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V(IV)O(2+) to hTF, as well as whether the conformation of hTF upon binding to V(IV)O(2+) or to its complexes is ch...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Mehtab S,Gonçalves G,Roy S,Tomaz AI,Santos-Silva T,Santos MF,Romão MJ,Jakusch T,Kiss T,Pessoa JC

    更新日期:2013-04-01 00:00:00

  • Reprint of "Anticancer activity of hydroxy- and sulfonamide-azobenzene platinum(II) complexes in cisplatin-resistant ovarian cancer cells".

    abstract::The syntheses of three platinum(II) complexes bearing sulfonamide-((E)-2-(4-methylphenylsulfonamido)-2',6'-difluoroazobenzene, HL1) and hydroxy-azo-2,6-difluorobenzene ((E)-2-((2,6-difluorophenyl)diazenyl)phenol, HL2) bidentate ligands is described. These complexes, [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), and [Pt(...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Samper KG,Marker SC,Bayón P,MacMillan SN,Keresztes I,Palacios Ò,Wilson JJ

    更新日期:2017-12-01 00:00:00

  • Irreversibly binding anti-metal chelate antibodies: Artificial receptors for pretargeting.

    abstract::Antibodies against metal chelates may potentially be used in biomedical applications such as targeted imaging and therapy of cancer. Highly specific monoclonal antibodies can be developed, but their binding strength needs to be maximized for them to be of practical use. In general, the half-life for dissociation of an...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章,评审


    authors: Corneillie TM,Whetstone PA,Meares CF

    更新日期:2006-05-01 00:00:00

  • O2-binding to heme: electronic structure and spectrum of oxyheme, studied by multiconfigurational methods.

    abstract::We have studied the ground state of a realistic model of oxyheme with multiconfigurational second-order perturbation theory (CASPT2). Our results show that the ground-state electronic structure is strongly multiconfigurational in character. Thus, the wavefunction is a mixture of many different configurations, of which...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Jensen KP,Roos BO,Ryde U

    更新日期:2005-01-01 00:00:00

  • Synthesis, characterization, and antibacterial activity of novel Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with vitamin K3-thiosemicarbazone.

    abstract::Vitamin K3-thiosemicarbazone (C12H11N3NaO4S2 x 5H2O, abbreviated as VT), a new Schiff base derivative, has been synthesized. Its crystal structure, determined by X-ray diffraction, is triclinic, space group P1. We have also prepared five novel complexes of VT with transition metals: [M(VT)(2)2H2O] x nH2O, (n = 1 and 2...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Li QX,Tang HA,Li YZ,Wang M,Wang LF,Xia CG

    更新日期:2000-01-30 00:00:00

  • A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor.

    abstract::Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)3](ClO4)2·2H2O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize th...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Zhang J,Yu Q,Li Q,Yang L,Chen L,Zhou Y,Liu J

    更新日期:2014-05-01 00:00:00

  • Coordination chemistry and solution structure of Fe(II)-peplomycin. Two possible coordination geometries.

    abstract::The solution structure of Fe(II)-peplomycin was determined from NMR data collected for this molecule. As found previously for Fe(II)- and Co(II)-bound bleomycin; the coordination sphere of the metal is composed of the primary and secondary amines in β-aminoalanine, the pyrimidine and imidazole rings in the pyrimidinyl...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Li Y,Lehmann T

    更新日期:2012-06-01 00:00:00

  • Synthesis and biocidal activity of Zn(II) complexes of some 2,2'-substituted diphenylamines.

    abstract::Binary as well as ternary complexes of Zn(II) with diphenylamine-2,2'-dicarboxylic acid (dpdc), diphenylamine-2-amino-2'-carboxylic acid (dpac), diphenylamine-2-hydroxy-2'-carboxylic acid (dphc), diphenylamine-2-mercapto-2'-carboxylic acid (dpmc), and N-(2-pyridino) anthranilic acid (npa) have been synthesized and cha...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Sharma RC,Parashar RK

    更新日期:1987-03-01 00:00:00

  • Synthesis, characterization and DNA binding studies of a zinc complex with 2,6-bis(benzimidazol-2-yl) pyridine.

    abstract::A zinc(II) complex having planar tridentate ligand, bzimpy, where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by UV, NMR, infrared spectroscopy and fluorescence spectra. The zinc complex acts as dibasic acids, in which N-H protons on benzimidazole moieties are responsible for a depr...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Wang J,Shuai L,Xiao X,Zeng Y,Li Z,Matsumura-Inoue T

    更新日期:2005-03-01 00:00:00

  • Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.

    abstract::To characterize heme oxygenase with a selenocysteine (SeCys) as the proximal iron ligand, we have expressed truncated human heme oxygenase-1 (hHO-1) His25Cys, in which Cys-25 is the only cysteine, in the Escherichia coli cysteine auxotroph strain BL21(DE3)cys. Selenocysteine incorporation into the protein was demonstr...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Jiang Y,Trnka MJ,Medzihradszky KF,Ouellet H,Wang Y,Ortiz de Montellano PR

    更新日期:2009-03-01 00:00:00

  • Synthesis, spectroscopy and antiproliferative activity of cis- and trans-platinum(II) complexes with diethyl (pyridin-4-ylmethyl)phosphate. X-ray crystal structure of trans-Pt(II) complex.

    abstract::Preparations of cis- and trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified and characterized by far-IR, 1H NMR, 13C NMR, 31P NMR and 195Pt NMR and microanalyses. The crystal and molecular structure of trans-platinum(II) complex i.e., tr...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Kalinowska U,Matławska K,Checińska L,Domagała M,Kontek R,Osiecka R,Ochocki J

    更新日期:2005-10-01 00:00:00

  • Synthesis, characterization and antibacterial studies of a copper(II) levofloxacin ternary complex.

    abstract::Solution behavior of levofloxacin (lvx) complexes with copper(II) in the presence and absence of phen was studied in aqueous solution, by potentiometry. The results obtained show that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lvx:phen ternary complexes are stable. Hence...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Sousa I,Claro V,Pereira JL,Amaral AL,Cunha-Silva L,de Castro B,Feio MJ,Pereira E,Gameiro P

    更新日期:2012-05-01 00:00:00

  • Synthesis and evaluation of the antibiotic and adjuvant antibiotic potential of organotin(IV) derivatives.

    abstract::A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) co...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Barbosa ASL,Guedes JS,da Silva DR,Meneghetti SMP,Meneghetti MR,da Silva AE,de Araujo MV,Alexandre-Moreira MS,de Aquino TM,de Siqueira Junior JP,de Araújo RSA,da Cruz RMD,Mendonça-Junior FJB

    更新日期:2018-03-01 00:00:00

  • Quantum mechanical investigation of aqueous desferrioxamine B metal complexes: trends in structure, binding, and infrared spectroscopy.

    abstract::A systematic density functional theory study supported by extended X-ray absorption fine structure (EXAFS) and infrared spectroscopic data was conducted to elucidate how structure and vibrational spectra of aqueous desferrioxamine B (DFOB) metal complexes vary with the metal ion identity. Structural parameters derived...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Kruft BI,Harrington JM,Duckworth OW,Jarzęcki AA

    更新日期:2013-12-01 00:00:00

  • Synthesis, properties, and antitumor effects of a new mixed phosphine gold(I) compound in human colon cancer cells.

    abstract::The antineoplastic potential of a new stable mixed phosphine gold(I) complex containing tris(tert-butyl)phosphine (tBu3P) and bis(diphenylphosphino)ethene (dppet), namely [Au(tBu3P)(dppet)Cl], has been investigated in the human colon cancer HCT-116 cell line. The (31)P NMR solution study, confirms the structural featu...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Lupidi G,Avenali L,Bramucci M,Quassinti L,Pettinari R,Khalife HK,Gali-Muhtasib H,Marchetti F,Pettinari C

    更新日期:2013-07-01 00:00:00

  • Relevance of the leaving group for antitumor activity of new platinum(II) compounds containing anthracene derivatives as a carrier ligand.

    abstract::A new anticancer-active platinum(II) compound [Pt(A9pyp)(dmso)(cbdca)], containing the E-1-(9-anthryl)-3-(2-pyridyl)-2-propenone ligand (abbreviated as A9pyp) has been synthesized by the replacement of the anionic chloride ligands in cis-[Pt(A9pyp)(dmso)Cl(2)] by the dianionic chelating cyclobutanedicarboxylate ligand...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Marqués-Gallego P,Contaldi S,den Dulk H,Monari M,Brouwer J,Jaehde U,Kalayda GV,Reedijk J

    更新日期:2009-12-01 00:00:00

  • Reactivity pathways for nitric oxide and nitrosonium with iron complexes in biologically relevant sulfur coordination spheres.

    abstract::The interaction of nitric oxide (NO) with iron-sulfur cluster proteins results in the formation of dinitrosyl iron complexes (DNICs) coordinated by cysteine residues from the peptide backbone or with low molecular weight sulfur-containing molecules like glutathione. Such DNICs are among the modes available in biology ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Harrop TC,Song D,Lippard SJ

    更新日期:2007-11-01 00:00:00

  • Synthesis and spectroscopy studies of copper(II) nitrate of sulfacetamide drug. Crystal structure of [Cu(sulfacetamide)2(NO3)2]. Antibacterial studies.

    abstract::The structural spectroscopic, and thermal properties of a complex of sulfacetamide (Hsacm) with Cu(II) have been investigated. The complex [Cu(Hsacm)2(NO3)2] crystallizes in the monoclinic system, space group P2(1)/n. The cell dimensions are a = 7.696(7) A, b = 8.017(7) A, c = 19.230(10), beta = 110.80(1) degree, V = ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Blasco F,Ortiz R,Perelló L,Borrás J,Amigó J,Debaerdemaeker T

    更新日期:1994-02-01 00:00:00

  • Fluorescence study of the interaction of Suwannee River fulvic acid with metal ions and Al3+-metal ion competition.

    abstract::In this study emission and synchronous-scan fluorescence spectroscopy have been used to investigate the interaction of the class A (oxygen seeking 'hard acid') metal Al(3+), with Suwannee River fulvic acid (SRFA), as well as competition between Al(3+) and several other metal ions (Ca(2+), Mg(2+), Cu(2+), Pd(2+), La(3+...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Zhao J,Nelson DJ

    更新日期:2005-02-01 00:00:00

  • Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change.

    abstract::HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1α. Prior s...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Pektas S,Knapp MJ

    更新日期:2013-09-01 00:00:00

  • The pH of HNO donation is modulated by ring substituents in Piloty's acid derivatives: azanone donors at biological pH.

    abstract::A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives, with electron-withdrawing and -donating substituents include methyl, nitro, fluoro, tri-isopropyl, trifl...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Sirsalmath K,Suárez SA,Bikiel DE,Doctorovich F

    更新日期:2013-01-01 00:00:00

  • Bis(L-cysteinato)gold(I): chemical characterization and identification in renal cortical cytoplasm.

    abstract::L-Cysteinatogold(I) was prepared by the reaction of L-cysteine with KAuBr4 in acidic media and its solubility determined from pH 4 to 10. The solubility at pH 7.4 and 37 degrees C is 1 microM. In the presence of excess cysteine, the solubility increases because of formation of bis(L-cysteinato)gold(I). The equilibrium...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Shaw CF 3rd,Schmitz G,Thompson HO,Witkiewicz P

    更新日期:1979-07-01 00:00:00

  • Metalloporphyrin mediated DNA cleavage by a low concentration of HaeIII restriction enzyme.

    abstract::The plasmid DNA scission by the restriction enzyme HaeIII was investigated in the presence of tetrakis(1-methylpyridinium-4-yl)porphyrin (H2TMPyP) and its manganese(III), iron(III), nickel(II), cobalt(III) and zinc(II) derivatives. The effect of metalloporphyrins on plasmid DNA cleavage was ascertained by gel electrop...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Tabata M,Nakajima K,Nyarko E

    更新日期:2000-03-01 00:00:00

  • Coordination modes of histidine. 4. Coordination structures in the copper(II)-L-histidine (1:2) system.

    abstract::The coordination structures of various species in the copper(II)-L-histidine (1:2) system in aqueous solution have been deduced by investigating the pH dependence of the electronic and circular dichroism spectra. The contribution to the spectra of the glycine-like and histamine-like binding modes of L-histidine has be...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Casella L,Gullotti M

    更新日期:1983-02-01 00:00:00

  • Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5'-GMP-N7)(2)].6H(2)O.

    abstract::We have synthesised the complex [Pt(CH(3)SCH(2)CH(2)SCH(3))(5'-GMP-N7)(2)].6H(2)O (1), where 5'-GMP is 5'-guanosine monophosphate, and determined its X-ray crystal structure. Pt(II) adopts a square-planar geometry in which the bases are coordinated head-to-tail (HT) in the Delta configuration. The nucleotide conformat...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Djuran MI,Milinkovic SU,Habtemariam A,Parsons S,Sadler PJ

    更新日期:2002-02-01 00:00:00

  • Effect of Zinc (II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring.

    abstract::The impact of Zn(2+) ion on interactions of flavonols galangin (Gal), kaempferol (Kae), quercetin (Que) and myricetin (Myr) with bovine serum albumin (BSA) in aqueous solution were studied by fluorescence quenching technique. The results exhibited that Zn(2+) ion affected significantly the interactions and the effect ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Cao S,Jiang X,Chen J

    更新日期:2010-02-01 00:00:00

  • DNA-binding and in vitro cytotoxic activity of platinum(II) complexes of curcumin and caffeine.

    abstract::Three Pt(II) complexes containing the natural ligands curcumin and caffeine, namely [Pt(curc)(PPh3)2]Cl (1), [PtCl(curc)(DMSO)] (2) (curc = deprotonated curcumin) and trans-[Pt(caffeine)Cl2(DMSO)] (3), were synthesized and fully characterized. The data obtained suggest that, for both 1 and 2, the anion of curcumin is ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Censi V,Caballero AB,Pérez-Hernández M,Soto-Cerrato V,Korrodi-Gregório L,Pérez-Tomás R,Dell'Anna MM,Mastrorilli P,Gamez P

    更新日期:2019-09-01 00:00:00

  • Reversible inactivation of cytochrome P450 by alkaline earth metal ions: auxiliary metal ion induced conformation change and formation of inactive P420 species in CYP101.

    abstract::The effects of the divalent alkaline-earth metal ions (Ca2+ and Mg2+) on the substrate binding affinity, spin-state transition at the heme active site, conformational properties as well as the stability of the active form of cytochrome P450cam (CYP 101) have been investigated using various spectroscopic and kinetic me...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Manna SK,Mazumdar S

    更新日期:2008-05-01 00:00:00

  • Magnetic properties of tunicate blood cells. I. Ascidia nigra.

    abstract::The magnetic properties of intact and freeze-dried blood cells of the tunicate Ascidia nigra and of model vanadium(III) and (IV) compounds as polycrystalline solids and in aqueous solution have been measured up to 50 kOe with a SQUID susceptometer. Corrections for the samples' diamagnetism were extracted from the temp...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Lee S,Kustin K,Robinson WE,Frankel RB,Spartalian K

    更新日期:1988-07-01 00:00:00

  • Desaturation of trans-octadecenoyl-acyl carrier protein by stearoyl-acyl carrier protein delta9 desaturase.

    abstract::Positional isomers of mono-unsaturated 18:1-ACP have been used as substrates for stearoyl-acyl carrier protein delta9 desaturase to test whether a C-H bond abstraction from either the C-9 or C-10 position could lead to rearranged products diagnostic for the production of an allylic radical intermediate. The reconstitu...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Broadwater JA,Laundre BJ,Fox BG

    更新日期:2000-01-15 00:00:00