Cell signaling, beyond cytosolic calcium in eukaryotes.

Abstract:

:Calcium functions as a secondary messenger within the cytosols of eukaryotes. This serves as a reference point to evaluate three related questions:Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction. 1. Calcium, as well as cyclic AMP, also functions as a paracrine messenger; how specific and extensive is this use? 2. Calcium binding proteins and calcium extrusion mechanisms have been identified in prokaryotes; does it function as a messenger? 3. The concentrations of other divalent cations, especially zinc and magnesium, are well regulated and perturbations have specific physiological impacts; are these divalents involved in information transfer? Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction.

journal_name

J Inorg Biochem

authors

Permyakov EA,Kretsinger RH

doi

10.1016/j.jinorgbio.2008.09.006

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

77-86

issue

1

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(08)00221-3

journal_volume

103

pub_type

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