Abstract:
:The inhibitory effect of Cu2+, Mn2+, Co2+, and I- on naproxen-induced photohemolysis was investigated. In order to better understand this effect, these ions were also tested for lipid peroxidation and protein crosslinking, which are among the main processes involved in erythrocyte membrane damage. The overall results support the hypothesis that metal cations act via a redox scavenging of the radicals which are produced on the lipid component of the membrane. This process occurs through hydrogen abstraction operated by photogenerated naproxen radicals. Moreover, copper can also act as a superoxide anion scavenger: its decay is noxious in photohemolysis, whereas it is not in lipid peroxidation. Metal cations, besides, are not able to scavenge protein crosslinking. On the other hand, iodide is able to reduce both processes because it acts as a heavy atom, favoring intersystem crossing to the unreactive triplet state of the drug, thus reducing naproxen photolysis and, as a consequence, the amount of the damaging species produced. This mechanism was supported by luminescence experiments performed in the absence and in the presence of iodide.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Giuffrida S,De Guidi G,Miano P,Sortino S,Condorelli G,Costanzo LLdoi
10.1016/0162-0134(95)00226-xsubject
Has Abstractpub_date
1996-09-01 00:00:00pages
253-63issue
4eissn
0162-0134issn
1873-3344pii
016201349500226Xjournal_volume
63pub_type
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journal_title:Journal of inorganic biochemistry
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journal_title:Journal of inorganic biochemistry
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of inorganic biochemistry
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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更新日期:2010-03-01 00:00:00