Dinuclear macrocyclic polyamine zinc(II) complexes: syntheses, characterization and their interaction with plasmid DNA.

abstract：:The Ce(IV)-mitoxantrone complex exhibits a higher lethality to Ehrlich ascites tumor cells than that of the free drug and shows stronger inhibition ability on the DNA synthesis of the tumor cells. Thus the Ce(IV)-mitoxantrone complex may become a more potent antitumor drug than mitoxantrone. The different interaction ...

journal_title：Journal of inorganic biochemistry

authors： Wang H,Yang P,Tian Y,Zhang Z,Zhao C

更新日期：1997-11-01 00:00:00

abstract：:With its about 100,000 three-dimensional structures, the Protein Data Bank is a copious source of information: it contains also some hundreds of structures of macromolecules complexed with lanthanide cations, which are examined here. These cations, which are found in a wide variety of protein types, were introduced to...

journal_title：Journal of inorganic biochemistry

authors： Djinovic-Carugo K,Carugo O

更新日期：2015-02-01 00:00:00

abstract：:A series of arene ruthenium(II) complexes with the general formula [(η(6)-arene)Ru(L)X2] (where arene=p-cymene, benzene, hexamethylbenzene or mesitylene, L=aminoflavone or aminochromone derivatives and X=Cl, I) were synthesized and characterized by elemental analysis, MS, IR and (1)H NMR spectroscopy. The stability of...

journal_title：Journal of inorganic biochemistry

authors： Pastuszko A,Majchrzak K,Czyz M,Kupcewicz B,Budzisz E

更新日期：2016-06-01 00:00:00

abstract：:[PtMe3(Me2CO)3]BF4 (1) reacts in acetone with 1,2,3,4-tetraacetyl-beta-D-glucopyranose (C2), pentaacetyl-alpha-D-glucopyranose (C3), pentaacetyl-beta-D-mannopyranose (C4) and pentaacetyl-beta-D-galactopyranose (C5) to give trimethyl(carbohydrate)platinum tetrafluoroborate complexes [PtMe3L]BF4 (2-5) (2, L=C2; 3, L=C3;...

journal_title：Journal of inorganic biochemistry

authors： Junicke H,Kluge R,Steinborn D

更新日期：2000-07-15 00:00:00

abstract：:Fusobacterium nucleatum is an anaerobic, Gram-negative bacteria linked to colon cancer. It is interesting to determine how metal ions interact with bacterial adhesin proteins. To this end, the coordination of ATDAAS-NH2 and MKKFL-NH2 fragments of Fusobacterium adhesin A (FadA) to copper(II) ions was studied by potenti...

journal_title：Journal of inorganic biochemistry

authors： Krupa K,Lesiów M,Stokowa-Sołtys K,Starosta R,Ptaszyńska N,Łęgowska A,Rolka K,Wernecki M,Cal M,Jeżowska-Bojczuk M

更新日期：2018-12-01 00:00:00

abstract：:The novel steroidal carrier ligand 17-α-[4'-ethynyl-dimethylbenzylamine]-17-β-testosterone (ET-dmba 1) and the steroid--C,N-chelate platinum(II) derivatives [Pt(ET-dmba)Cl(L)] (L = DMSO (2) and PTA (3; PTA =1,3,5-triaza-7-phosphaadamantane)) have been prepared. Values of IC(50) were calculated for the new platinum com...

journal_title：Journal of inorganic biochemistry

authors： Ruiz J,Rodríguez V,Cutillas N,Espinosa A,Hannon MJ

更新日期：2011-04-01 00:00:00

abstract：:A number of oxidovanadium(IV) complexes have been reported to display anticancer activity. A theranostic approach, based on the simultaneous observation of both the effect of oxidovanadium(IV) complexes on cell viability and the disclosure of their intracellular fate, is possible by using oxidovanadium(IV) complexes f...

journal_title：Journal of inorganic biochemistry

authors： Lovisari M,Volpi G,Marabello D,Cadamuro S,Deagostino A,Diana E,Barge A,Gallicchio M,Boscaro V,Ghibaudi E

更新日期：2017-05-01 00:00:00

abstract：:The reaction of thiosemicarbazones (TSCs) with [Au(I)(THT)Cl], THT=tetrahydrothiophene, has been investigated. The resulting gold(I) complexes have been characterized by a range of spectroscopic techniques: NMR spectroscopy, mass spectrometry, microanalysis and infrared spectroscopy. The in vitro antimalarial data for...

journal_title：Journal of inorganic biochemistry

authors： Khanye SD,Smith GS,Lategan C,Smith PJ,Gut J,Rosenthal PJ,Chibale K

更新日期：2010-10-01 00:00:00

abstract：:The coordination structures of various species in the copper(II)-L-histidine (1:2) system in aqueous solution have been deduced by investigating the pH dependence of the electronic and circular dichroism spectra. The contribution to the spectra of the glycine-like and histamine-like binding modes of L-histidine has be...

journal_title：Journal of inorganic biochemistry

authors： Casella L,Gullotti M

更新日期：1983-02-01 00:00:00

abstract：:The antitumor activity of a ruthenium(II) polypyridyl complex, Δ-[Ru(bpy)2(HPIP)](ClO4)2 (Δ-Ru1, where bpy=2,2'-bipyridine, HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline), was evaluated. The in vivo experiments showed that Δ-Ru1 inhibited the growth of a human cervical carcinoma cell line (HeLa) xenotrans...

journal_title：Journal of inorganic biochemistry

authors： Wang JQ,Zhang PY,Ji LN,Chao H

更新日期：2015-05-01 00:00:00

abstract：:This work describes in situ synthesis and application of the zinc glutamate Bio Metal-Organic Framework (BioMOF) supported on cellulose fabrics as a dual material for nitric oxide (NO) and 5-fluorouracil (5FU) controlled delivery for wound and/or skin cancer therapy. In situ synthesis of BioMOF on the cotton fabric wa...

journal_title：Journal of inorganic biochemistry

authors： Noorian SA,Hemmatinejad N,Navarro JAR

更新日期：2019-12-01 00:00:00

abstract：:The binding of Cu2+ to native and copper-free dopamine beta-monooxygenase has been investigated by potentiometric titrations using a Cu2+-selective electrode. Stoichiometric formation constants have been determined from regression analysis of the resulting titration curves. The results establish a stoichiometry of fou...

journal_title：Journal of inorganic biochemistry

authors： Syvertsen C,Gaustad R,Schrøder K,Ljones T

更新日期：1986-01-01 00:00:00

abstract：:The binding of Ru(phen)(2)dppz(2+) (dppz=dipyrido[3,2-a:2',3'-c]phenazine) to DNA was investigated at pH 7.0 and 25 degrees C using stopped-flow and spectrophotometric methods. Equilibrium measurements show that two modes of binding, whose characteristics depend on the polymer to dye ratio (C(P)/C(D)), are operative. ...

journal_title：Journal of inorganic biochemistry

authors： Biver T,Cavazza C,Secco F,Venturini M

更新日期：2007-03-01 00:00:00

abstract：:The experiments here reported evidence on the importance of the residual charge of a nucleotide derivative, for the adsorption on nHAP (hydroxyapatite nanocrystals), in water solution. We found that the simple presence of phosphates on the nucleotide derivative does not guarantee adsorption on nHAP. On the other hand,...

journal_title：Journal of inorganic biochemistry

authors： Benedetti M,Antonucci D,De Castro F,Girelli CR,Lelli M,Roveri N,Fanizzi FP

更新日期：2015-12-01 00:00:00

abstract：:The discovery of new metal-selective complexing agents may be facilitated by applying an in vitro selection strategy. Such a strategy was recently devised to identify and enrich populations of bacteriophage that rely on Mg(II)-, Zn(II)-, or Au(III)-selective stabilization for survival in the presence of denaturing ure...

journal_title：Journal of inorganic biochemistry

authors： Whang T,Daly B,Yin J

更新日期：1996-07-01 00:00:00

abstract：:The interaction of Rh2(OAc)4 with human serum albumin (HSA) has been studied by absorption difference spectroscopy, CD spectroscopy, and quantitative precipitating HSA-antibody test. Our results demonstrate that this rhodium complex reacts easily with HSA at several ratios of reagents. The Rh atoms are coordinated to ...

journal_title：Journal of inorganic biochemistry

authors： Trynda L,Pruchnik F

更新日期：1995-04-01 00:00:00

abstract：:The bifunctional Pt(IV) conjugate cis,cis,trans-diamminedichloridobis(valproato)platinum(IV), based on the cisplatin square-plane with two axial valproato (2-propylpentanoate, VPA) ligands, has been re-synthesized with a modified procedure and its biological activity was compared with that of its isomer cis,cis,trans-...

journal_title：Journal of inorganic biochemistry

authors： Alessio M,Zanellato I,Bonarrigo I,Gabano E,Ravera M,Osella D

更新日期：2013-12-01 00:00:00

abstract：:A series of new 3d metal complexes with 5-chloro-quinolin-8-ol (ClQ), [Mn(ClQ)2] (1), [Fe(ClQ)3] (2), [Co(ClQ)2(H2O)2] (3), [Ni(ClQ)2(H2O)2] (4), [Cu(ClQ)2] (5), [Zn(ClQ)2(H2O)2] (6), [Mn(ClQ)3]·DMF (7) and [Co(ClQ)3]·DMF·(EtOH)0.35 (8) (DMF=N,N-dimethylformamide), has been synthesized and characterized by elemental a...

journal_title：Journal of inorganic biochemistry

authors： Potočňák I,Vranec P,Farkasová V,Sabolová D,Vataščinová M,Kudláčová J,Radojević ID,Čomić LR,Markovic BS,Volarevic V,Arsenijevic N,Trifunović SR

更新日期：2016-01-01 00:00:00

abstract：:Aluminium (Al) has been measured in human breast tissue, and may be a contributory factor in breast cancer development. At the 10th Keele meeting, we reported that long-term exposure to Al could increase migratory properties of oestrogen-responsive MCF-7 human breast cancer cells suggesting a role for Al in the metast...

journal_title：Journal of inorganic biochemistry

authors： Bakir A,Darbre PD

更新日期：2015-11-01 00:00:00

abstract：:We report the synthesis and toxicity of a series of rhenium(I) tricarbonyl complexes incorporating the trisaminomethylethane (TAME) ligand. Compounds with the (TAME)Re(CO)(3)(+) cation were synthesized via several routes, including by use of Re(CO)(5)X precursors as well as the aqueous cation Re(CO)(3)(H(2)O)(3)(+). S...

journal_title：Journal of inorganic biochemistry

authors： Binkley SL,Barone NV,Underwood AC,Milsted A,Franklin BR,Herrick RS,Ziegler CJ

更新日期：2010-06-01 00:00:00

abstract：:Gold(III) complexes bearing bidentate ligands based on the 1,10-phenanthroline and 2,2'-bipyridine scaffolds have shown promising anticancer activity against a variety of tumor cell lines. In particular, our laboratory has previously found that a pseudo five coordinate gold(III) complex possessing the 2,9-di-sec-butyl...

journal_title：Journal of inorganic biochemistry

authors： Olsen PM,Ruiz C,Lussier D,Le BK,Angel N,Smith M,Hwang CB,Khatib R,Jenkins J,Adams K,Getcher J,Tham F,Chen ZG,Wilson EH,Eichler JF

更新日期：2014-12-01 00:00:00

abstract：:The effect of inositol hexakisphosphate, 2,3-diphosphoglycerate, dextran sulphate, and heparin on the spectroscopic (absorbance, circular dichroism, EPR) properties of the nitric oxide derivative of ferrous dromedary (Camelus dromedarius) hemoglobin was investigated. The results obtained show that: (i) all polyanions ...

journal_title：Journal of inorganic biochemistry

authors： Ascenzi P,Santucci R,Desideri A,Amiconi G

更新日期：1988-04-01 00:00:00

abstract：:The three metal-binding ligands of the archetype Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylase, taurine/alphaKG dioxygenase (TauD), were systematically mutated to examine the effects of various ligand substitutions on enzyme activity and metallocenter properties. His99, coplanar with alphaKG and Fe(II), i...

journal_title：Journal of inorganic biochemistry

authors： Grzyska PK,Müller TA,Campbell MG,Hausinger RP

更新日期：2007-05-01 00:00:00

abstract：:Three new platinum(II) complexes with pendent morpholine were synthesized, namely complex 1 ([Pt(L)Cl]CF3SO3), complex 2 ([Pt(L)(NH3)](CF3SO3)2) and complex 3 ([Pt(L)(PPh3)](CF3SO3)2), where L = 4'-[4-(4-morpholinobutyloxy)phenyl]-2,2':6',2″-terpyridine and PPh3 = triphenylphosphine. The detailed molecular structures ...

journal_title：Journal of inorganic biochemistry

authors： Chai K,Kuang W,Lan Z,Zhang L,Jiang Y,Han T,Niu J,Wang J,Duan X

更新日期：2019-03-01 00:00:00

abstract：:Methanobactins are copper-binding ligands produced by aerobic methanotrophic microorganisms. A quantitative understanding of their potential role in methanotrophic copper acquisition requires the investigation of their copper complexes under relevant pH conditions. In this study, a chemical speciation model describing...

journal_title：Journal of inorganic biochemistry

authors： Pesch ML,Christl I,Hoffmann M,Kraemer SM,Kretzschmar R

更新日期：2012-11-01 00:00:00

abstract：:Iron overload can act as catalyst for the formation of free radicals, which may promote oxidant-mediated breast carcinogenesis. However, the association between iron and breast cancer has not been comprehensively elucidated. In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6...

journal_title：Journal of inorganic biochemistry

authors： Cheng M,Liu P,Xu LX

更新日期：2020-09-01 00:00:00

abstract：:An iron porphycene, a structural isomer of iron porphyrin, with trifluoromethyl groups at the peripheral position of the framework was incorporated into sperm whale apomyoglobin. The prepared myoglobin shows the higher O(2) affinity than the native protein. However, the oxygen affinity of the reconstituted myoglobin i...

journal_title：Journal of inorganic biochemistry

authors： Matsuo T,Ito K,Nakashima Y,Hisaeda Y,Hayashi T

更新日期：2008-02-01 00:00:00

abstract：:The antineoplastic potential of a new stable mixed phosphine gold(I) complex containing tris(tert-butyl)phosphine (tBu3P) and bis(diphenylphosphino)ethene (dppet), namely [Au(tBu3P)(dppet)Cl], has been investigated in the human colon cancer HCT-116 cell line. The (31)P NMR solution study, confirms the structural featu...

journal_title：Journal of inorganic biochemistry

authors： Lupidi G,Avenali L,Bramucci M,Quassinti L,Pettinari R,Khalife HK,Gali-Muhtasib H,Marchetti F,Pettinari C

更新日期：2013-07-01 00:00:00

abstract：:Bis(picolinato)oxovanadium(IV) [VO(pic)2] is one of the most potent insulin-mimetic vanadium complexes. To probe coordination structural changes of this complex in vivo and provide insights into the origin of its high potency, an electron spin-echo envelope modulation (ESEEM) study was performed on organs (kidney, liv...

journal_title：Journal of inorganic biochemistry

authors： Fukui K,Fujisawa Y,OhyaNishiguchi H,Kamada H,Sakurai H

更新日期：1999-11-01 00:00:00

abstract：:Uranium is an element belonging to the actinide series. It is ubiquitous in rock, soil, and water. Uranium is found in the ecosystem due to mining and milling industrial activities and processing to nuclear fuel, but also to the extensive use of phosphate fertilizers. Understanding uranium binding in vivo is critical,...

journal_title：Journal of inorganic biochemistry

authors： Garai A,Delangle P

更新日期：2020-02-01 00:00:00