当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > The synthesis, lipophilicity and cytotoxic effects of new ruthenium(II) arene complexes with chromone derivatives.

The synthesis, lipophilicity and cytotoxic effects of new ruthenium(II) arene complexes with chromone derivatives.

Abstract：

:A series of arene ruthenium(II) complexes with the general formula [(η(6)-arene)Ru(L)X2] (where arene=p-cymene, benzene, hexamethylbenzene or mesitylene, L=aminoflavone or aminochromone derivatives and X=Cl, I) were synthesized and characterized by elemental analysis, MS, IR and (1)H NMR spectroscopy. The stability of the selected complexes was assessed by UV-Vis spectroscopy in 24-hour period. The lipophilicity of the synthesized complexes was determined by the shake-flask method, and their cytotoxicity evaluated in vitro on patient-derived melanoma populations. The most active complexes against melanoma cells contain 7-aminoflavone and 6-aminoflavone as a ligand. The relationship between the cytotoxicity of all the obtained compounds and their logP values was determined and briefly analyzed with two different patterns observed.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Pastuszko A,Majchrzak K,Czyz M,Kupcewicz B,Budzisz E

doi

10.1016/j.jinorgbio.2016.02.020

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

133-41

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(16)30045-9

journal_volume

159

pub_type

杂志文章

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