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Molecular recognition patterns of 2-aminopurine versus adenine: a view through ternary copper(II) complexes.

Abstract：

:In contrast to the comprehensive structural information about metal complexes with adenine, the corresponding to its isomer 2-aminopurine (H2AP) is extremely poor. With the aim to rationalize the metal binding pattern of H2AP, we report the molecular and/or crystal structure of four novel compounds with various iminodiacetate-like (IDA-like) copper(II) chelates: [Cu(IDA)(H2AP)(H2O)]·H2O (1), [Cu(MIDA)(H2AP)(H2O)]·3H2O (2), {[Cu(NBzIDA)(H2AP)]·1.5H2O}n (3) and [Cu(MEBIDA)(H2AP)(H2O)]·3.5 H2O (4), where IDA, MIDA, NBzIDA and MEBIDA are R=H, CH3, benzyl- and p-tolyl- in R-N-(CH2-COO-)2 ligands, respectively. Synthesis strategies include direct reactions of copper(II) chelates with H2AP (alone, for 1 and 3) and/or with the base pairs H2AP:thymine (1-4) or H2AP:cytosine (3). Moreover, these compounds have been also investigated by spectral and thermal methods. Regardless of the N-derivative of the IDA chelator, molecular recognition between H2AP and the referred Cu(II)-chelates only displays the formation of the Cu-N7(purine-like) bond what is clearly in contrast to what was previously reported for adenine. The metal binding pattern of 2-aminopurine is discussed on the basis of the electronic effects and steric hindrance of the 2-amino exocyclic group.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Domínguez-Martín A,Choquesillo-Lazarte D,González-Pérez JM,Castiñeiras A,Niclós-Gutiérrez J

doi

10.1016/j.jinorgbio.2011.05.009

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1073-80

issue

8

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(11)00124-3

journal_volume

105

pub_type

杂志文章

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