当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Novel short-chain analogues of somatostatin as ligands for Cu(II) ions. Role of the metal ion binding on the spatial structure of the ligand.

Novel short-chain analogues of somatostatin as ligands for Cu(II) ions. Role of the metal ion binding on the spatial structure of the ligand.

Abstract：

:In this paper we present the studies on coordination abilities of two short-chain analogues of somatostatin with free N-terminal and protected amino group towards copper (II) ions. The octreotide is the most popular analogue of the somatostatin (peptide hormone) used in medicine. Somatostatin analogues are used in diagnosis and treatment of the neuroendocrine tumors. Both analyzed analogues are characterized by the presence of two His instead of Cys residues in characteristic fragment of native peptide. We characterize coordination abilities of the ligands using potentiometric and spectroscopic methods. His-analogues of somatostatin are effective ligands for copper (II) ions. Both peptides are able to form the complexes with the cyclic structure.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Marciniak A,Cebrat M,Czyżnikowska Ż,Brasuń J

doi

10.1016/j.jinorgbio.2012.08.023

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

10-7

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(12)00275-9

journal_volume

117

pub_type

杂志文章

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