当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes.

The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes.

Abstract：

:The effect of AlCl(3) on the (Na(+)/K(+))ATPase activity of freeze-thawed synaptosomes, isolated from rat brain cortex, has been studied. The AlCl(3) action on the enzyme hydrolytic activity was examined using in vitro and in vivo approaches. Following exposure to AlCl(3) using both in vitro (synaptosomes incubated in the presence of AlCl(3) for 5 min) and in vivo (synaptosomes isolated from rats that received 0.03 g AlCl(3)/day for 4 months) approaches, the (Na(+)/K(+))ATPase activity was inhibited in a concentration-dependent way. The maximal inhibitory effect (approximately 60%) was observed in the presence of a AlCl(3) concentration >75 microM and at non-limiting ATP concentrations. Conversely, AlCl(3) did not inhibit the enzyme activity when UTP was used as substrate instead of ATP. Analysis of the substrate dependence of membrane-bound (Na(+)/K(+))ATPase by a computer simulation model suggests that the AlCl(3)-induced inhibitory effect is characterised by a reduction of the rate-limiting step velocity of the reaction cycle. Moreover, it seems that aluminium can induce impairment of the interprotomeric interaction within the oligomeric ensemble of membrane-bound (Na(+)/K(+))ATPase. In fact, this effect was accompanied by a slight, but significant, decrease of readily accessible SH groups, which are involved in the maintenance of the membrane-bound (Na(+)/K(+))ATPase oligomeric structure. In conclusion, during exposure to aluminium, reduction of the activation of membrane-bound (Na(+)/K(+))ATPase by high ATP concentrations occurs, which results in a partial inhibition of the enzyme.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Silva VS,Gonçalves PP

doi

10.1016/s0162-0134(03)00257-5

subject

Has Abstract

pub_date

2003-09-15 00:00:00

pages

143-50

issue

1

eissn

0162-0134

issn

1873-3344

pii

S0162013403002575

journal_volume

97

pub_type

杂志文章

相关文献

JOURNAL OF INORGANIC BIOCHEMISTRY文献大全
  • Synthesis, characterization and antibacterial studies of a copper(II) levofloxacin ternary complex.

    abstract：:Solution behavior of levofloxacin (lvx) complexes with copper(II) in the presence and absence of phen was studied in aqueous solution, by potentiometry. The results obtained show that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lvx:phen ternary complexes are stable. Hence...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.02.003

    authors： Sousa I,Claro V,Pereira JL,Amaral AL,Cunha-Silva L,de Castro B,Feio MJ,Pereira E,Gameiro P

    更新日期：2012-05-01 00:00:00

  • Synthesis, characterization and biological activity of copper complexes with pyridoxal thiosemicarbazone derivatives. X-ray crystal structure of three dimeric complexes.

    abstract：:A dimeric copper complex of the unsubstituted pyridoxal thiosemicarbazone (H(2)L), [[Cu(HL)(OH(2))](2)]Cl(2).2H(2)O, previously tested on Friend murine cell lines has been recently resynthesized to evaluate its behavior on different murine and human leukemic cell lines and has been compared, in vitro and in vivo, with...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2003.09.011

    authors： Belicchi Ferrari M,Bisceglie F,Pelosi G,Tarasconi P,Albertini R,Dall'Aglio PP,Pinelli S,Bergamo A,Sava G

    更新日期：2004-02-01 00:00:00

  • New copper(I) and heteronuclear copper(I)-ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity.

    abstract：:A new family of copper(I) complexes of general formula [Cu(dppe)(NN)]+ have been synthesized and fully characterized, with dppe=1.2-bis(diphenylphosphino)ethane and NN representing several bidentate heteroaromatic ligands: 2,2'-bipy=2.2'-bipyridine (1), Me2bpy=4.4'-dimethyl-2,2'-bipyridine (2), dpytz=3-(2-pyridyl)-5,6...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2017.01.007

    authors： Lopes J,Alves D,Morais TS,Costa PJ,Piedade MF,Marques F,Villa de Brito MJ,Helena Garcia M

    更新日期：2017-04-01 00:00:00

  • Synthesis, characterization and biological activities of mononuclear Co(III) complexes as potential bioreductively activated prodrugs.

    abstract：:Aiming to investigate the use of tridentate ligands to develop new bireductively activated prodrugs, two N(2)O-donor ligands (HL1: [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine; and HL2: [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were used to synthesize new Co(III) complexes, 1 and 2. Both complexes were chara...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2009.07.008

    authors： Souza ET,Castro LC,Castro FA,do Canto Visentin L,Pinheiro CB,Pereira MD,de Paula Machado S,Scarpellini M

    更新日期：2009-10-01 00:00:00

  • Nanocomposite of functional silver metal containing curcumin biomolecule model systems: Protein BSA bioavailability.

    abstract：:Curcumin, a constituent of Curcuma longa L-Zingiberaceae is used in traditional Indian and worldwide medicine and shows anticancer and antioxidant properties. Curcumin has numerous biological and pharmacological activities but due to its hydrophobic nature, the major drawback is poor absorption and rapid elimination, ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111210

    authors： Shedge AA,Pansare SV,Khairkar SR,Chhatre SY,Chakrabarti S,Nagarkar AA,Pansare AV,Patil VR

    更新日期：2020-11-01 00:00:00

  • Response and tolerance of root border cells to aluminum toxicity in soybean seedlings.

    abstract：:Root border cells (RBCs) and their secreted mucilage are suggested to participate in the resistance against toxic metal cations, including aluminum (Al), in the rhizosphere. However, the mechanisms by which the individual cell populations respond to Al and their role in Al resistance still remain unclear. In this rese...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2011.04.004

    authors： Cai MZ,Wang FM,Li RF,Zhang SN,Wang N,Xu GD

    更新日期：2011-07-01 00:00:00

  • Synthesis, characterization, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new functionalized terpyridine platinum(II) complexes.

    abstract：:Three new platinum(II) complexes with pendent morpholine were synthesized, namely complex 1 ([Pt(L)Cl]CF3SO3), complex 2 ([Pt(L)(NH3)](CF3SO3)2) and complex 3 ([Pt(L)(PPh3)](CF3SO3)2), where L = 4'-[4-(4-morpholinobutyloxy)phenyl]-2,2':6',2″-terpyridine and PPh3 = triphenylphosphine. The detailed molecular structures ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2018.12.003

    authors： Chai K,Kuang W,Lan Z,Zhang L,Jiang Y,Han T,Niu J,Wang J,Duan X

    更新日期：2019-03-01 00:00:00

  • Metal ligand substitution and evidence for quinone formation in taurine/alpha-ketoglutarate dioxygenase.

    abstract：:The three metal-binding ligands of the archetype Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylase, taurine/alphaKG dioxygenase (TauD), were systematically mutated to examine the effects of various ligand substitutions on enzyme activity and metallocenter properties. His99, coplanar with alphaKG and Fe(II), i...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.01.011

    authors： Grzyska PK,Müller TA,Campbell MG,Hausinger RP

    更新日期：2007-05-01 00:00:00

  • A singular value decomposition approach for kinetic analysis of reactions of HNO with myoglobin.

    abstract：:The reactions of several horse heart myoglobin species with nitrosyl hydride, HNO, derived from Angeli's salt (AS) and Piloty's acid (PA) have been followed by UV-visible, (1)H NMR and EPR spectroscopies. Spectral analysis of myoglobin-derived speciation during the reactions was obtained by using singular value decomp...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.10.005

    authors： Zapata AL,Kumar MR,Pervitsky D,Farmer PJ

    更新日期：2013-01-01 00:00:00

  • Synthesis, characterization, and structure-activity relationship of the antimicrobial activities of dinuclear N-heterocyclic carbene (NHC)-silver(I) complexes.

    abstract：:The three dinuclear silver(I) complexes of N-heterocyclic carbene (NHC) ligands, [Ag2(L-1a)](PF6)2·2CH3CN (Ag-1a), [Ag2(L-2)2](PF6)2·H2O (Ag-2), and [Ag2(L-4)2](PF6)2·2CH3CN (Ag-4), were synthesized by reactions of Ag2O with the corresponding PF6- salt of the NHC precursors indicated as H4L-1(PF6)4, H2L-2(PF6)2, and H...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.06.031

    authors： Sakamoto R,Morozumi S,Yanagawa Y,Toyama M,Takayama A,Kasuga NC,Nomiya K

    更新日期：2016-10-01 00:00:00

  • Rapid non-equilibrium aluminium-ligand interactions: studies on the precipitation of aluminium by laser light scattering, ultrafiltration and centrifugation.

    abstract：:The study aimed to develop simple assays to study aluminium-ligand interactions in natural/biological systems where equilibrium is rarely reached and thus where the initial seconds or hours of interactions are important. The immediate and non-equilibrium precipitation of aluminium hydroxide, in aqueous solution at neu...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(01)00311-7

    authors： Jugdaohsingh R,Salim N,McCrohan CR,White KN,Thompson RP,Powell JJ

    更新日期：2001-11-01 00:00:00

  • Inhibitiory effects of gold(III) ions on ribonuclease and deoxyribonuclease.

    abstract：:Inhibitory effects of gold(III) ions (Au(III)) on ribonuclease A (RNase A) and deoxyribonuclease I (DNase I) were investigated at neutral pH. RNase A was completely inhibited by 3 molar equivalents of Au(III) ions. DNase I was inhibited by 10 molar equivalents of Au(III) ions. Stoichiometric analyses suggest that Au(I...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2006.09.021

    authors： Maruyama T,Sonokawa S,Matsushita H,Goto M

    更新日期：2007-01-01 00:00:00

  • Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents.

    abstract：:The rates at which phosphonocarboxylate and diphosphonate ligands remove iron from the serum iron transport protein transferrin at 25 degrees C and pH 7.4 have been evaluated. These ligands show a combination of saturation and first-order kinetics with respect to the free ligand concentrations. The ability of the liga...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2004.08.008

    authors： Harris WR,Brook CE,Spilling CD,Elleppan S,Peng W,Xin M,Wyk JV

    更新日期：2004-11-01 00:00:00

  • Study on nucleic acid (CT-DNA and yeast tRNA) binding behaviors and cytotoxic properties of a heterodinuclear Ru(II)-Co(III) polypyridyl complex.

    abstract：:A heterodinuclear (Ru(II), Co(III)) metal polypyridyl complex [(phen)(2)Ru(bpibH(2))Co(phen)(2)](5+) {phen = 1,10-phenanthroline, bpibH(2) = 1,4-bis([1,10]phebanthroline-[5,6-d]imidazol-2-yl)-benzene} has been designed and synthesized. The comparative study on the interactions of the Ru(II)-Co(III) complex with calf t...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2010.08.006

    authors： Liang X,Zou X,Tan L,Zhu W

    更新日期：2010-12-01 00:00:00

  • Interaction of vanadium(IV) with human serum apo-transferrin.

    abstract：:The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V(IV)O(2+) to hTF, as well as whether the conformation of hTF upon binding to V(IV)O(2+) or to its complexes is ch...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.12.020

    authors： Mehtab S,Gonçalves G,Roy S,Tomaz AI,Santos-Silva T,Santos MF,Romão MJ,Jakusch T,Kiss T,Pessoa JC

    更新日期：2013-04-01 00:00:00

  • HENRYK - An endless source of metal coordination surprises.

    abstract：:The basic knowledge about biological inorganic chemistry, thermodynamics and metal binding sites of metalloproteins is crucial for the understanding of their metal binding-structure-function relationship. Metal-peptide complexes are useful and commonly used models of metal-enzyme active sites, among which copper and z...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.02.030

    authors： Kołkowska P,Hecel A,Kędzierska D,Ostrowska M,Walencik PK,Wątły J,Zdyb K,Spodzieja M,Rodziewicz-Motowidło S,Potocki S,Łuczkowski M,Gumienna-Kontecka E,Rowińska-Żyrek M

    更新日期：2016-10-01 00:00:00

  • Synthesis, characterization and DNA-binding properties of a new cobalt(II) complex: Co(bbt)2Cl2.

    abstract：:A new bis(N-benzyl-benzotriazole)dichloro Co(II) complex (Co(bbt)(2)Cl(2)) was synthesized and the structure was characterized by X-ray crystallography, IR spectrum and elemental analysis. The electrochemical characterization of Co(bbt)(2)Cl(2) was measured in detail, and the interaction of this Co(II) complex with fi...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2005.03.017

    authors： Jiao K,Wang QX,Sun W,Jian FF

    更新日期：2005-06-01 00:00:00

  • Investigation of metal complexes with metallothionein in rat tissues by hyphenated techniques.

    abstract：:The potential of hyphenated techniques based on a combination of microbore reversed-phase (RP) HPLC or capillary zone electrophoresis (CZE) with inductively coupled plasma (ICP) or electrospray (ES) mass spectrometry (MS) was demonstrated for the characterization of metal complexes with metallothionein in rat liver an...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(01)00380-4

    authors： Połec K,Peréz-Calvo M,García-Arribas O,Szpunar J,Ribas-Ozonas B,Lobinski R

    更新日期：2002-01-15 00:00:00

  • BioMOF@cellulose fabric composites for bioactive molecule delivery.

    abstract：:This work describes in situ synthesis and application of the zinc glutamate Bio Metal-Organic Framework (BioMOF) supported on cellulose fabrics as a dual material for nitric oxide (NO) and 5-fluorouracil (5FU) controlled delivery for wound and/or skin cancer therapy. In situ synthesis of BioMOF on the cotton fabric wa...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.110818

    authors： Noorian SA,Hemmatinejad N,Navarro JAR

    更新日期：2019-12-01 00:00:00

  • Effect of Zinc (II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring.

    abstract：:The impact of Zn(2+) ion on interactions of flavonols galangin (Gal), kaempferol (Kae), quercetin (Que) and myricetin (Myr) with bovine serum albumin (BSA) in aqueous solution were studied by fluorescence quenching technique. The results exhibited that Zn(2+) ion affected significantly the interactions and the effect ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2009.10.014

    authors： Cao S,Jiang X,Chen J

    更新日期：2010-02-01 00:00:00

  • The two distinctive metal ion binding domains of the wheat metallothionein Ec-1.

    abstract：:Metallothioneins are small cysteine-rich proteins believed to play a role, among others, in the homeostasis of essential metal ions such as Zn(II) and Cu(I). Recently, we could show that wheat E(c)-1 is coordinating its six Zn(II) ions in form of metal-thiolate clusters analogously to the vertebrate metallothioneins. ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2008.11.008

    authors： Peroza EA,Kaabi AA,Meyer-Klaucke W,Wellenreuther G,Freisinger E

    更新日期：2009-03-01 00:00:00

  • A proximal tryptophan in NO synthase controls activity by a novel mechanism.

    abstract：:The heme of neuronal nitric oxide synthase (nNOS) participates in O2 activation but also binds self-generated NO, resulting in reversible feedback inhibition. We utilized mutagenesis to investigate if a conserved tryptophan residue (Trp409), which engages in pi-stacking with the heme and hydrogen bonds to its axial cy...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(00)00176-8

    authors： Adak S,Stuehr DJ

    更新日期：2001-02-01 00:00:00

  • Ferrocenyl naphthalene diimides as tetraplex DNA binders.

    abstract：:Seven ferrocenyl naphthalene diimide (FND) ligands were synthesized. Each had a higher affinity for tetraplex DNA than for either single- or double-stranded DNA. The FND binding affinities were >105M-1 in 0.10M AcOH-AcONa or AcOH-AcOK (pH5.5) containing 0.10M NaCl or KCl. The FNDs with the highest binding affinities f...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.11.020

    authors： Sato S,Takenaka S

    更新日期：2017-02-01 00:00:00

  • Haem-peptide-protein interactions: Part 5. The haem undecapeptide microperoxidase-11 (Fe3+MP-11)/human serum albumin (HSA) reaction in aqueous methanolic solution. A simple system demonstrating the effect of hydrophobicity on ligand release from a ligand-

    abstract：:Previous studies of the interaction of the haem undecapeptide (MP-11) with lipidated human serum albumin in aqueous solution have been extended to a range of MeOH/H2O solution compositions. It is demonstrated that the kinetic mechanism for the interaction does not change from a simple second- and first-order reversibl...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(93)80009-x

    authors： Adams PA,Thumser AE

    更新日期：1993-04-01 00:00:00

  • Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines.

    abstract：:In this study we report the synthesis, characterization and a thorough biological evaluation of twelve organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes. The chosen hqH ligands bear various halogen atoms in different positions which enables to study effect of the substituents on physico-chemical and biological pr...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2018.05.009

    authors： Kljun J,León IE,Peršič Š,Cadavid-Vargas JF,Etcheverry SB,He W,Bai Y,Turel I

    更新日期：2018-09-01 00:00:00

  • Complexes containing benzimidazolyl-phenol ligands and Ln(III) ions: Synthesis, spectroscopic studies and preliminary cytotoxicity evaluation.

    abstract：:Fourteen new complexes were obtained from Ln(III)(NO3)3∙n-H2O and the chromophores 2-(1H-benzo[d]imidazol-2-yl)-phenol (Bzp1) or 2-(5-methyl-1H-benzo[d]imidazol-2-yl)-phenol (Bzp2). The complete characterization allowed us to assign unequivocally the structures of all the complexes. The techniques used for this purpos...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.110842

    authors： Hernández-Morales A,Rivera JM,López-Monteon A,Lagunes-Castro S,Castillo-Blum S,Cureño-Hernández K,Flores-Parra A,Villaseñor-Granados O,Colorado-Peralta R

    更新日期：2019-12-01 00:00:00

  • Genotoxic assessment of the copper chelated compounds Casiopeinas: Clues about their mechanisms of action.

    abstract：:Casiopeinas is the generic name of a group of copper chelated complexes designed to be used as antineoplastic. Some of these compounds have shown promising results, and in fact, one of them named Casiopeina III-ia has completed preclinical trials and is ready to start clinical phase I in Mexico. As part of the tests t...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.11.007

    authors： Serment-Guerrero J,Bravo-Gomez ME,Lara-Rivera E,Ruiz-Azuara L

    更新日期：2017-01-01 00:00:00

  • Catalytic properties of thioredoxin immobilized on superparamagnetic nanoparticles.

    abstract：:Thioredoxin (Trx1), a very important protein for regulating intracellular redox reactions, was immobilized on iron oxide superparamagnetic nanoparticles previously coated with 3-aminopropyltriethoxysilane (APTS) via covalent coupling using the EDC (1-ethyl-3-{3-dimethylaminopropyl}carbodiimide) method. The system was ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2011.02.006

    authors： Netto CG,Nakamatsu EH,Netto LE,Novak MA,Zuin A,Nakamura M,Araki K,Toma HE

    更新日期：2011-05-01 00:00:00

  • A molecular cytogenetic approach to studying platinum resistance.

    abstract：:The technique of comparative genomic hybridisation (CGH) has until recently been used to screen for common genomic abnormalities in fresh tumour material; it has identified previously unrecognised regions of amplification associated with poor prognosis subtypes of breast cancer and lymphoma. Our group has applied this...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(99)00140-3

    authors： Hiorns LR,Seckl MJ,Paradinas F,Sharp SY,Skelton LA,Brunstrom G,Newlands ES,Kelland LR,Leyland-Jones B

    更新日期：1999-10-01 00:00:00

  • Structural and biological aspects of copper (II) complexes with 2-methyl-3-amino-(3H)-quinazolin-4-one.

    abstract：:A series of new copper (II) complexes with 2-methyl-3-amino(3H)-quinazolin-4-one (MAQ) and various anions (Cl-, Br-, ClO(-)4, NO(-)3, SCN-, and SO(2-)4 was prepared. Their structures and properties were characterized by elemental analysis, IR, UV-Vis and ESR spectroscopy, molar conductivity, and magnetic moment measur...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(96)00122-5

    authors： Ramadan AM

    更新日期：1997-02-15 00:00:00