Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents.

Abstract:

:The rates at which phosphonocarboxylate and diphosphonate ligands remove iron from the serum iron transport protein transferrin at 25 degrees C and pH 7.4 have been evaluated. These ligands show a combination of saturation and first-order kinetics with respect to the free ligand concentrations. The ability of the ligands to remove iron from transferrin appears to be subject to steric restrictions that are essentially identical to those associated with the ability of a ligand to substitute for the synergistic carbonate anion. This observation supports the hypothesis that the first-order component for iron removal involves a mechanism in which the rate-limiting step is the slow substitution of the synergistic carbonate by the incoming chelating agent. Studies on monoferric transferrins indicate that phosphonocarboxylates are unusually effective at removing iron from the C-terminal site of the protein. Difference UV spectroscopy has been used to show that the phosphonocarboxylates bind strongly to apotransferrin. It is suggested that the rapid release of iron from the C-terminal site may be due to the binding of the ligand to an allosteric anion-binding site in the C-terminal lobe of the protein.

journal_name

J Inorg Biochem

authors

Harris WR,Brook CE,Spilling CD,Elleppan S,Peng W,Xin M,Wyk JV

doi

10.1016/j.jinorgbio.2004.08.008

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1824-36

issue

11

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(04)00226-0

journal_volume

98

pub_type

杂志文章
  • The effect of spermine concentration on the solution structure of complexes formed in copper(II)/adenosine 5'-triphosphate/phosphoserine system.

    abstract::Quaternary systems of copper(II) complexes with adenosine 5'-triphosphate, O-phospho L-serine and with equimolar or excessive amount of spermine have been investigated. The studies have been performed in aqueous solution. Types of complexes and the overall stability constants have been determined using the potentiomet...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2010.04.006

    authors: Jastrzab R,Runka T,Skowronek P,Lomozik L

    更新日期:2010-08-01 00:00:00

  • Cu(II)-selective bispidine-dye conjugates.

    abstract::The substitution of tetradentate bispidine ligands with rhodamine and cyanine dye molecules, coupled to an amine donor, forming an amide as potential fifth donor, is described. Bispidines are known to lead to very stable Cu(II) complexes, and the coordination to Cu(II) was expected to efficiently quench the fluorescen...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.05.009

    authors: Brox D,Comba P,Herten DP,Kimmle E,Morgen M,Rühl CL,Rybina A,Stephan H,Storch G,Wadepohl H

    更新日期:2015-07-01 00:00:00

  • Synthesis, spectroscopic and magnetic resonance studies of mercury (II) and methylmercury (II) complexes of azathioprine, a biologically active mercaptopurine derivative.

    abstract::Synthetic and spectroscopic studies of the Hg(II) and MeHg(II) complexes of azathioprine (AZA), a biologically active 6-mercaptopurine derivative, were undertaken. The altered coordination behavior of AZA with respect to the parent mercaptopurine, with sulfur no longer being the primary donor atom, was confirmed. As c...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/0162-0134(94)85021-6

    authors: Chifotides HT,Dunbar KR,Katsaros N,Pneumatikakis G

    更新日期:1994-08-15 00:00:00

  • Cognitive dysfunction associated with aluminum hydroxide-induced macrophagic myofasciitis: A reappraisal of neuropsychological profile.

    abstract::Patients with macrophagic myofasciitis (MMF) present with diffuse arthromyalgias, chronic fatigue, and cognitive disorder. Representative features of MMF-associated cognitive dysfunction include attentional dysfunction, dysexecutive syndrome, visual memory deficit and left ear extinction. Our study aims to reevaluate ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2017.09.019

    authors: Aoun Sebaiti M,Kauv P,Charles-Nelson A,Van Der Gucht A,Blanc-Durand P,Itti E,Gherardi RK,Bachoud-Levi AC,Authier FJ

    更新日期:2018-04-01 00:00:00

  • Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I.

    abstract::EPR-based potentiometric titrations are a well-established method for determining the reduction potentials of cofactors in large and complex proteins with at least one EPR-active state. However, such titrations require large amounts of protein. Here, we report a new method that requires an order of magnitude less prot...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2016.04.025

    authors: Wright JJ,Salvadori E,Bridges HR,Hirst J,Roessler MM

    更新日期:2016-09-01 00:00:00

  • Genotoxic assessment of the copper chelated compounds Casiopeinas: Clues about their mechanisms of action.

    abstract::Casiopeinas is the generic name of a group of copper chelated complexes designed to be used as antineoplastic. Some of these compounds have shown promising results, and in fact, one of them named Casiopeina III-ia has completed preclinical trials and is ready to start clinical phase I in Mexico. As part of the tests t...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2016.11.007

    authors: Serment-Guerrero J,Bravo-Gomez ME,Lara-Rivera E,Ruiz-Azuara L

    更新日期:2017-01-01 00:00:00

  • Copper(I) interaction with model peptides of WD6 and TM6 domains of Wilson ATPase: regulatory and mechanistic implications.

    abstract::With the aim to investigate the mechanism of Cu(I) transport by Wilson ATPase (ATP7B), we have studied the interaction of the peptides 2K10p (CH(3)CO-Lys-Gly-Met-Thr-Cys-Ala-Ser-Cys-Val-His-Asn-Lys-CONH(2)), and 2K8p (CH(3)CO-Lys-Leu-Cys-Ile-Ala-Cys-Pro-Cys-Ser-Lys-CONH(2)), part of the sixth metal binding domain (WD6...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2004.05.013

    authors: Myari A,Hadjiliadis N,Fatemi N,Sarkar B

    更新日期:2004-09-01 00:00:00

  • Kinetic study of catalytic CO(2) hydration by water-soluble model compound of carbonic anhydrase and anion inhibition effect on CO(2) hydration.

    abstract::A kinetic study of CO(2) hydration was carried out using the water-soluble zinc model complex with water-soluble nitrilotris(2-benzimidazolylmethyl-6-sulfonate) L1S, [L1SZn(OH(2))](-), mimicking the active site of carbonic anhydrase, in the presence and absence of anion inhibitors NCS(-) and Cl(-). The obtained rate c...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(01)00419-6

    authors: Nakata K,Shimomura N,Shiina N,Izumi M,Ichikawa K,Shiro M

    更新日期:2002-04-28 00:00:00

  • The intercalation to DNA of bipyridyl complexes of platinum(II) with thioureas.

    abstract::The non-covalent interaction of the complexes [Pt(bpy)(R,R'NCSNR'',R''')(2)]Cl(2) (bpy=2,2'-bipyridine; R=R'=R''=R'''=H; R=Me, R'=R''=R'''=H; R=n-Bu, R'=R''=R'''=H; R=p-tolyl, R'=R''=R'''=H; R=Et, R'=H, R''=Et, R'''=H) with calf thymus DNA has been studied at pH 7 and 25 degrees C. The processes give rise to: (i) reve...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2004.11.002

    authors: Cusumano M,Di Pietro ML,Giannetto A,Vainiglia PA

    更新日期:2005-02-01 00:00:00

  • Preparation of two types of silver-doped fluorescent carbon dots and determination of their antibacterial properties.

    abstract::The preparation and performance of doped antibacterial carbon dots (CDs) have been the research hotspot. In this paper, we report the preparation of two blue light-emitting silver-doped CDs, CD-1 and CD-2, through one- and two-step routes, respectively, by using polyethyleneimine, citric acid, and AgNO3 as raw materia...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2020.111306

    authors: Zhao D,Liu X,Zhang R,Xiao X,Li J

    更新日期:2021-01-01 00:00:00

  • Reaction mechanism of the binuclear zinc enzyme glyoxalase II - A theoretical study.

    abstract::The glyoxalase system catalyzes the conversion of toxic methylglyoxal to nontoxic d-lactic acid using glutathione (GSH) as a coenzyme. Glyoxalase II (GlxII) is a binuclear Zn enzyme that catalyzes the second step of this conversion, namely the hydrolysis of S-d-lactoylglutathione, which is the product of the Glyoxalas...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2008.10.016

    authors: Chen SL,Fang WH,Himo F

    更新日期:2009-02-01 00:00:00

  • Effect of aluminium on migration of oestrogen unresponsive MDA-MB-231 human breast cancer cells in culture.

    abstract::Aluminium (Al) has been measured in human breast tissue, and may be a contributory factor in breast cancer development. At the 10th Keele meeting, we reported that long-term exposure to Al could increase migratory properties of oestrogen-responsive MCF-7 human breast cancer cells suggesting a role for Al in the metast...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.09.001

    authors: Bakir A,Darbre PD

    更新日期:2015-11-01 00:00:00

  • Engineering and biological assessment of double core nanoplatform for co-delivery of hybrid fluorophores to human melanoma.

    abstract::We investigated new development in photodynamic therapy (PDT), aiming at enhanced tumor selectivity and biocompatibility, which included application of a third-generation photosensitizing agent, i.e. xanthene-origin Rose Bengal (RB) co-encapsulated with up-converting NaYF4 nanoparticles (NPs) co-doped with lanthanide ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2020.111088

    authors: Bazylińska U,Wawrzyńczyk D,Szewczyk A,Kulbacka J

    更新日期:2020-07-01 00:00:00

  • Synthesis, characterization, and antitumor activity of unusual pseudo five coordinate gold(III) complexes: distinct cytotoxic mechanism or expensive ligand delivery systems?

    abstract::Gold(III) complexes bearing bidentate ligands based on the 1,10-phenanthroline and 2,2'-bipyridine scaffolds have shown promising anticancer activity against a variety of tumor cell lines. In particular, our laboratory has previously found that a pseudo five coordinate gold(III) complex possessing the 2,9-di-sec-butyl...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2014.08.014

    authors: Olsen PM,Ruiz C,Lussier D,Le BK,Angel N,Smith M,Hwang CB,Khatib R,Jenkins J,Adams K,Getcher J,Tham F,Chen ZG,Wilson EH,Eichler JF

    更新日期:2014-12-01 00:00:00

  • Structural and biological aspects of copper (II) complexes with 2-methyl-3-amino-(3H)-quinazolin-4-one.

    abstract::A series of new copper (II) complexes with 2-methyl-3-amino(3H)-quinazolin-4-one (MAQ) and various anions (Cl-, Br-, ClO(-)4, NO(-)3, SCN-, and SO(2-)4 was prepared. Their structures and properties were characterized by elemental analysis, IR, UV-Vis and ESR spectroscopy, molar conductivity, and magnetic moment measur...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(96)00122-5

    authors: Ramadan AM

    更新日期:1997-02-15 00:00:00

  • Derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5' AMP. Use as enzymatic labels with glycogen phosphorylase B.

    abstract::Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5' AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy. The activities of these complexes as substitutes of 5' AMP as allosteric activators of glycogen phosphorylase b have been tested....

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/0162-0134(85)80011-8

    authors: Puig P,Terron A,Moreno V

    更新日期:1985-11-01 00:00:00

  • Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid.

    abstract::In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF6, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor ce...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2020.111021

    authors: Graminha AE,Honorato J,Dulcey LL,Godoy LR,Barbosa MF,Cominetti MR,Menezes AC,Batista AA

    更新日期:2020-05-01 00:00:00

  • Coordination chemistry of the HNO ligand with hemes and synthetic coordination complexes.

    abstract::The coordination chemistry of the one-electron reduced form of nitric oxide, termed a nitroxyl or nitrosyl hydride (NO- or HNO), is described with special focus on its interaction with hemes and heme model complexes. Nitroxyl intermediates have been proposed in the catalytic cycles of several heme-based nitrite and ni...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jinorgbio.2004.11.005

    authors: Farmer PJ,Sulc F

    更新日期:2005-01-01 00:00:00

  • Synthesis and DNA binding of mu-[2,9-bis(2-imidazo[4,5-f][1,10]phenanthroline)-1,10-phenanthroline]bis[1,10-phenanthrolinecopper(II)].

    abstract::A binuclear complex [(phen)Cu(mu-bipp)Cu(phen)](ClO(4))(4), where phen=1,10-phenanthroline and bipp=2,9-bis(2-imidazo[4,5-f][1,10]phenanthroline)-1,10-phenanthroline, has been synthesized and its interaction with calf-thymus DNA in the buffer containing 5mM Tris and 50mM NaCl has been studied by means of electronic ab...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2005.08.002

    authors: Wu JZ,Yuan L,Wu JF

    更新日期:2005-11-01 00:00:00

  • Heteroditopic P,N ligands in gold(I) complexes: synthesis, structure and cytotoxicity.

    abstract::New heteroditopic, bi- and multidentate imino- and aminophosphine ligands were synthesised and complexed to [AuCl(THT)] (THT=tetrahydrothiophene). X-ray crystallography confirmed Schiff base formation in three products, the successful reduction of the imino-group to the sp(3)-hybridised amine in several instances, and...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.01.014

    authors: Traut-Johnstone T,Kanyanda S,Kriel FH,Viljoen T,Kotze PD,van Zyl WE,Coates J,Rees DJ,Meyer M,Hewer R,Williams DB

    更新日期:2015-04-01 00:00:00

  • Covalent attachment of the heme to Synechococcus hemoglobin alters its reactivity toward nitric oxide.

    abstract::The cyanobacterium Synechococcus sp. PCC 7002 produces a monomeric hemoglobin (GlbN) implicated in the detoxification of reactive nitrogen and oxygen species. GlbN contains a b heme, which can be modified under certain reducing conditions. The modified protein (GlbN-A) has one heme-histidine C-N linkage similar to the...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2017.09.018

    authors: Preimesberger MR,Johnson EA,Nye DB,Lecomte JTJ

    更新日期:2017-12-01 00:00:00

  • Polyoxometalates: Study of inhibitory kinetics and mechanism against α-glucosidase.

    abstract::Alpha-glucosidase is considered to be an important target for the treatment of noninsulin-dependent diabetes. In this work, the inhibitory effects of polyoxometalates (POMs) affected by three different factors (heteroatom, transition metal substitution element and vanadium substitution number) on α-glucosidase were st...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2019.110784

    authors: Chi G,Wang L,Chen B,Li J,Hu J,Liu S,Zhao M,Ding X,Li Y

    更新日期:2019-10-01 00:00:00

  • Ferrocenyl naphthalene diimides as tetraplex DNA binders.

    abstract::Seven ferrocenyl naphthalene diimide (FND) ligands were synthesized. Each had a higher affinity for tetraplex DNA than for either single- or double-stranded DNA. The FND binding affinities were >105M-1 in 0.10M AcOH-AcONa or AcOH-AcOK (pH5.5) containing 0.10M NaCl or KCl. The FNDs with the highest binding affinities f...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2016.11.020

    authors: Sato S,Takenaka S

    更新日期:2017-02-01 00:00:00

  • Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.

    abstract::In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms t...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.07.003

    authors: MacDonald TC,Nehzati S,Sylvain NJ,James AK,Korbas M,Caine S,Pickering IJ,George GN,Krone PH

    更新日期:2015-10-01 00:00:00

  • Improved syntheses of β-octabromo-meso-triarylcorrole derivatives.

    abstract::In spite of significant applications as starting materials for a variety of metallocorrole derivatives, free-base β-octabromo-meso-triarylcorroles continue to be viewed as inaccessible. The reasons range from the need for tedious column-chromatographic purification to limitations of the reductive demetallation protoco...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.07.017

    authors: Capar J,Berg S,Thomas KE,Beavers CM,Gagnon KJ,Ghosh A

    更新日期:2015-12-01 00:00:00

  • Differential binding of anions to the active site of Cu,Zn superoxide dismutase. A study of the Co,Zn enzyme derivative.

    abstract::The reaction of N3- with Co,Zn superoxide dismutase, a good analogue of the native Cu,Zn enzyme, was studied in the presence and absence of phosphate, which is known to perturb the spectroscopic properties of the cobalt chromophore in the Co,Zn enzyme. EPR, NMR, and optical titrations demonstrated the formation of dif...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/0162-0134(88)80006-0

    authors: Desideri A,Paci M,Capo C,Calabrese L,Rotilio G

    更新日期:1988-08-01 00:00:00

  • Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.

    abstract::The prostate gland of humans and other animals accumulates a level of zinc that is 3-10 times greater than that found in other tissues. Associated with this ability to accumulate zinc is a rapid zinc uptake process in human prostate cells, which we previously identified as the hZIP1 zinc transporter. We now provide ad...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(03)00249-6

    authors: Franklin RB,Ma J,Zou J,Guan Z,Kukoyi BI,Feng P,Costello LC

    更新日期:2003-08-01 00:00:00

  • Introduction of a specific binding domain on myoglobin surface by new chemical modification.

    abstract::A new myoglobin, reconstituted with a modified zinc protoporphyrin, having a total of four ammonium groups at the terminal of the two propionate side chains was constructed to introduce a substrate binding site. The protein with a positively charged patch on the surface formed a stable complex with negatively charged ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(00)00153-7

    authors: Hayashi T,Ando T,Matsuda T,Yonemura H,Yamada S,Hisaeda Y

    更新日期:2000-11-01 00:00:00

  • Molecular recognition patterns of 2-aminopurine versus adenine: a view through ternary copper(II) complexes.

    abstract::In contrast to the comprehensive structural information about metal complexes with adenine, the corresponding to its isomer 2-aminopurine (H2AP) is extremely poor. With the aim to rationalize the metal binding pattern of H2AP, we report the molecular and/or crystal structure of four novel compounds with various iminod...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2011.05.009

    authors: Domínguez-Martín A,Choquesillo-Lazarte D,González-Pérez JM,Castiñeiras A,Niclós-Gutiérrez J

    更新日期:2011-08-01 00:00:00

  • Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds.

    abstract::Supranutritional selenium (Se) intake and high serum Se levels have been associated epidemiologically with increased risk for type 2 diabetes, suggesting adverse effects of dietary Se compounds and/or antioxidant selenoenzymes on the sensitivity of target tissues for insulin. Here, we compared the capability of inorga...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2011.03.010

    authors: Pinto A,Speckmann B,Heisler M,Sies H,Steinbrenner H

    更新日期:2011-06-01 00:00:00