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Synthesis, characterization and DNA-binding properties of a new cobalt(II) complex: Co(bbt)2Cl2.

Abstract：

:A new bis(N-benzyl-benzotriazole)dichloro Co(II) complex (Co(bbt)(2)Cl(2)) was synthesized and the structure was characterized by X-ray crystallography, IR spectrum and elemental analysis. The electrochemical characterization of Co(bbt)(2)Cl(2) was measured in detail, and the interaction of this Co(II) complex with fish sperm DNA was studied by electrochemical techniques and ultraviolet-visible (UV-Vis) spectrophotometry. The cyclic voltammetry (CV) showed that Co(bbt)(2)Cl(2) had two reduction peaks and one oxidation peak on gold electrode. It was found that the currents of both the reduction peaks and the oxidation peak decreased significantly in the presence of DNA compared with those in the absence of DNA, which indicated that Co(bbt)(2)Cl(2) could interact with DNA. The binding of DNA with the complex was not only electrostatic binding but also intercalation.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Jiao K,Wang QX,Sun W,Jian FF

doi

10.1016/j.jinorgbio.2005.03.017

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1369-75

issue

6

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(05)00078-4

journal_volume

99

pub_type

杂志文章

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