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Inhibition of the GDP/GTP exchange reaction of ras p21 by aluminum ion.

Abstract：

:In an effort to understand the biochemical mechanisms of aluminum-induced neurotoxicity, we investigated the effects of aluminum ion, Al3+, on the Mg(2+)- and nucleotide-dependent protein, ras p21. Picomolar Al3+ concentrations inhibited the GTPase activity of ras p21 in an Mg(2+)-dependent manner, consistent with an Al3+/Mg2+ competition mechanism. GTPase activity was inhibited by 60% in the presence of 100 microM Mg2+ and 2.9 x 10(-10) M Al3+. Kinetic studies demonstrated that the mode of Al(3+)-induced inhibition of ras p21 GTPase activity changed from competitive to mixed non-competitive as the number of ras p21 turnovers increased. Further dissection of the ras p21 cycle revealed that Mg(2+)-dependent GDP/GTP exchange was the Al(3+)-sensitive step.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Landino LM,Macdonald TL

doi

10.1016/s0162-0134(96)00188-2

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

99-102

issue

2

eissn

0162-0134

issn

1873-3344

pii

S0162013496001882

journal_volume

66

pub_type

杂志文章

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