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Trace metal uptake in liver cells. 1. Influence of albumin in the medium on the uptake of copper by hepatoma cells.

Abstract：

:Cultured rat hepatoma cells (HTC-cells) were used to study the transfer of copper from a well-defined medium to and across the cell membrane and particularly the role of albumin in this process. HTC-cells, maintained in a minimal salt-glucose medium, accumulated far more copper than when maintained in the same medium, but supplemented with albumin. In the latter case, the Cu uptake strongly depended on the molar Cu/albumin ratio. The results suggest a role of albumin in the uptake of trace metals. The results indicate the presence of two types of binding sites for copper on the cell membrane. The sites of the first type bind copper very strongly and are probably responsible for the uptake of copper under physiological conditions. Their number was estimated to be about 10(6) per cell. Those of the second type only bind copper when the molar Cu/albumin ratio exceeds a value of about 1, i.e., under extreme, unphysiological conditions. Furthermore, the results suggest a direct interaction of the Cu-albumin complex with these strong binding sites as a first step in Cu uptake processes.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

van den Berg GJ,van den Hamer CJ

doi

10.1016/0162-0134(84)80016-1

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

73-84

issue

2

eissn

0162-0134

issn

1873-3344

pii

0162-0134(84)80016-1

journal_volume

22

pub_type

杂志文章

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