Abstract：
:Metal-arene complexes containing bioactive natural-product derived ligands can have new and unusual properties. We report the synthesis, characterization and antiproliferative activity of two new Ru(II) arene complexes with imidazole (dichlorido complex 1) or bipyridyl (chlorido complex 2) ligands conjugated to 18β-glycyrrhetinic acid, an active triterpenoid metabolite of Glycyrrhiza glabra. In general, the conjugated ligands and complexes showed only moderate activity against HeLa (cervical), MCF-7 (breast) and A2780 (ovarian) cancer cells, although the activity of complex 2 in the former two cell lines approached that of the drug cisplatin. Complex 2 (in contrast to complex 1) also exhibited significant activity towards both Gram-positive S. aureus and Gram-negative E. coil bacteria. Complex 2 can induce condensation of DNA and enhances the generation of intracellular reactive oxygen species (ROS). The conjugation of natural products to ligands in organometallic half-sandwich complexes provides a strategy to enhance their biological activities.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Kong Y,Chen F,Su Z,Qian Y,Wang FX,Wang X,Zhao J,Mao ZW,Liu HKdoi
10.1016/j.jinorgbio.2018.02.004subject
Has Abstractpub_date
2018-05-01 00:00:00pages
194-199eissn
0162-0134issn
1873-3344pii
S0162-0134(17)30759-6journal_volume
182pub_type
杂志文章abstract：:We present hereby an overview of the reactions of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, with ligands (primarily oxygen) and electrons, pointing out where necessary unresolved facts or questionable interpretations. ...
journal_title：Journal of inorganic biochemistry
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pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
