Abstract:
:Three binuclear Ru(II) complexes with two [Ru(bpy)(2)(pip)](2+)-based subunits {where bpy=2,2'-bipyridine and pip=2-phenylimidazo[4,5-f][1,10]phenanthroline} being linked by varied lengths of flexible bridges, were synthesized and characterized by (1)H NMR, elemental analysis, UV-visible (UV-vis) and photoluminescence spectroscopy. The structures of the three complexes were optimized by density functional theory calculations. The interaction of the complexes with calf thymus DNA was investigated by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN)(6)](4-), DNA competitive binding with ethidium bromide, DNA melting experiments, and viscosity measurements. The experimental results indicated that the three complexes bound to the DNA most probably in a threading intercalation binding mode with high DNA binding constant values three orders of magnitude greater than the DNA binding constant value reported for proven DNA intercalator, mononuclear counterpart [Ru(bpy)(2)(p-mopip)](2+) {p-mopip=2-(4-methoxylphenyl)imidazo[4,5-f][1,10]phenanthroline}.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Ju CC,Zhang AG,Yuan CL,Zhao XL,Wang KZdoi
10.1016/j.jinorgbio.2010.12.004subject
Has Abstractpub_date
2011-03-01 00:00:00pages
435-43issue
3eissn
0162-0134issn
1873-3344pii
S0162-0134(10)00285-0journal_volume
105pub_type
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