Citrate binding of Al3+ and Fe3+.

Abstract:

:Citrate occurs at about 0.1 mM in blood plasma and is the most likely small molecule plasma binder of both Al3+ and Fe3+. This paper assesses published stability constants for citrate binding to each metal ion. From pH 2 to 5 Al3+ forms a neutral complex with citrate that may be absorbed into the body in the upper regions of the gastrointestinal tract. It is especially dangerous to ingest aluminum-containing antacids with citrus fruit or juices. Ignoring the likely occurrence of a competing 2:1 citrate-Fe3+ complex necessitates adjustments in reported stability constants for Fe3+ binding to transferrin. In the blood, plasma transferrin steals both Fe3+ and Al3+ from citrate.

journal_name

J Inorg Biochem

authors

Martin RB

doi

10.1016/0162-0134(86)80081-2

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

181-7

issue

2-3

eissn

0162-0134

issn

1873-3344

pii

0162-0134(86)80081-2

journal_volume

28

pub_type

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