Abstract：
:M98Q amicyanin is isolated with zinc bound to its type 1 copper-binding site. The influence of the axial ligand of the type 1 copper site on metal specificity is strongest prior to the completion of protein folding and adoption of the final type 1 site geometry. The preference for zinc over copper correlated with the selectivity of apoamicyanin in vitro in the partially folded, rather than the completely folded state. These results suggest that metal incorporation in vivo occurs during protein folding in the periplasm and not to a preformed type 1 site.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Ma JK,Lee S,Choi M,Bishop GR,Hosler JP,Davidson VLdoi
10.1016/j.jinorgbio.2007.09.007subject
Has Abstractpub_date
2008-02-01 00:00:00pages
342-6issue
2eissn
0162-0134issn
1873-3344pii
S0162-0134(07)00265-6journal_volume
102pub_type
杂志文章abstract：:Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic l...
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journal_title：Journal of inorganic biochemistry
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