Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.

Abstract:

:The stoichiometry and stability constants of the Ga(III) complexes of 8-hydroxyquinoline (HQ), 8-hydroxyquinoline-5-sulfonate (HQS), maltol, thiomaltol, allomaltol and thioallomaltol were determined by means of pH-potentiometry, UV-vis spectrophotometry, spectrofluorometry and (1)H NMR spectroscopy in aqueous solution. Spectrofluorometry was used to determine the stability constants of the Ga(III)-HQ species in water. Formation of [GaL](2+), [GaL(2)](+) and [GaL(3)] complexes was found and the Ga(III) binding ability of the ligands followed the order: thioallomaltol

journal_name

J Inorg Biochem

authors

Enyedy ÉA,Dömötör O,Varga E,Kiss T,Trondl R,Hartinger CG,Keppler BK

doi

10.1016/j.jinorgbio.2012.08.005

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

189-97

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(12)00255-3

journal_volume

117

pub_type

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