Glycosidase- and β-lactamase-like activity of dinuclear copper(II) patellamide complexes.

Abstract:

:Prochloron, a blue-green algae belonging to ancient prokaryotes, produces, like other cyanobacteria, cyclic pseudo-peptides, which are also found in its obligate symbiont ascidiae (Lissoclinum patellum). Although research has focused for some time on the putative metabolic function of these cyclic peptides, to date it is still not understood. Their role might be connected to the increased concentrations of divalent metal ions, especially Cu(II), found in ascidiae. Dinuclear copper(II) complexes of cyclic pseudo-peptides revealed a broad hydrolytic capacity, including carboanhydrase and phosphatase activity. This study reports their β-lactamase as well as α- and β-glycosidase activity with kcat=(11.34±0.91)ˑ10(-4)s(-1) for β-lactamase, kcat=(1.55±0.13)ˑ10(-4)s(-1) for α-glycosidase and kcat=(1.22±0.09)ˑ10(-4)s(-1) for β-glycosidase activity.

journal_name

J Inorg Biochem

authors

Comba P,Eisenschmidt A,Kipper N,Schießl J

doi

10.1016/j.jinorgbio.2016.02.014

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

70-5

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(16)30039-3

journal_volume

159

pub_type

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