Synthesis, characterization, and in vitro cytotoxic effects of K4 [PtCl2ATP].

abstract：:Hexacyanochromate ion, (Cr(CN)6)3-, was applied to ribonuclease T1 (RNase T1), which specifically cleaves RNA chains at guanylic acid residues. From kinetic studies, this anion was shown to bind to the active site of RNase T1 as a competitive inhibitor. Therefore, the line broadening effect of NMR resonances due to bi...

journal_title：Journal of inorganic biochemistry

authors： Inagaki F,Shimada I

更新日期：1986-10-01 00:00:00

abstract：:Iron is an essential nutrient for most bacteria. Depending on the oxygen available in the surrounding environment, iron is found in two distinct forms: ferrous (Fe(II)) or ferric (Fe(III)). Bacteria utilize different transport systems for the uptake of the two different forms of iron. In oxic growth conditions, iron i...

journal_title：Journal of inorganic biochemistry

authors： Carpenter C,Payne SM

更新日期：2014-04-01 00:00:00

abstract：:Changes in speciation of copper(II) in reactions with epigallocatechin gallate (EGCG) and gallic acid (GA) as a function of pH have been investigated by multifrequency (X- and S-band) EPR spectroscopy in the fluid and frozen states. The EPR spectra show the formation of three distinct mononuclear species with each of ...

journal_title：Journal of inorganic biochemistry

authors： Pirker KF,Baratto MC,Basosi R,Goodman BA

更新日期：2012-07-01 00:00:00

abstract：:Chromomycin A(3) (CHR) and mithramycin (MTR), members of the aureolic acid anticancer antibiotics, supposedly act by inhibiting transcription via reversible association with DNA. The complex(es) with bivalent cation such as Mg(2+) and Zn(2+) is (are) the DNA-binding ligand(s). In this paper, we report a detailed study...

journal_title：Journal of inorganic biochemistry

authors： Devi PG,Pal S,Banerjee R,Dasgupta D

更新日期：2007-01-01 00:00:00

abstract：:A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positio...

journal_title：Journal of inorganic biochemistry

authors： Iglesias BA,Barata JFB,Pereira PMR,Girão H,Fernandes R,Tomé JPC,Neves MGPMS,Cavaleiro JAS

更新日期：2015-12-01 00:00:00

abstract：:The present Mössbauer spectroscopic studies of isolated bacterioferritin and whole cells of Pseudomonas aeruginosa have shown that the iron core of bacterioferritin is not altered on isolation. These studies have also shown that the bacterioferritin core is typically 85% oxidized within the cell and may contain a sign...

journal_title：Journal of inorganic biochemistry

authors： Kadir FH,Read NM,Dickson DP,Greenwood C,Thompson A,Moore GR

更新日期：1991-09-01 00:00:00

abstract：:Subcellular fractions were prepared by differential centrifugation from heart and liver of a lamb labeled with 75Se-selenite. Crude fractions of nuclei, mitochondria, and microsomes from both tissues were solubilized with sodium dodecyl sulfate and chromatographed on columns of sephacryl S-200. A low molecular weight ...

journal_title：Journal of inorganic biochemistry

authors： Beilstein MA,Tripp MJ,Whanger PD

更新日期：1981-12-01 00:00:00

abstract：:Twenty ferritin samples were prepared at pH 6.5 with average loadings of 0-89 Fe atoms per molecule. Nuclear magnetic relaxation times T1 and T2 were measured at 3 degrees C, 23 degrees C, and at 37 degrees C and at field strength from 0.025 to 1.5 T. The field dependence, temperature dependence, and approximate equal...

journal_title：Journal of inorganic biochemistry

authors： Vymazal J,Brooks RA,Bulte JW,Gordon D,Aisen P

更新日期：1998-09-01 00:00:00

abstract：SYNOPSIS:MnII complexes formed with cis- and trans-DO2A (DO2A=1,4,7,10-tetraazacyclododecane-1,4 (or 1,7) -diacetic acid) chelators were investigated by pH-potentiometry, 1H relaxometry, UV-vis spectrophotometry and cyclic voltammetry. The physico-chemical characteristics of MnII complexes of these structure isomers do...

journal_title：Journal of inorganic biochemistry

authors： Garda Z,Forgács A,Do QN,Kálmán FK,Timári S,Baranyai Z,Tei L,Tóth I,Kovács Z,Tircsó G

更新日期：2016-10-01 00:00:00

abstract：:Catalase (CAT) and myeloperoxiase (MPO) are heme-containing enzymes that have attracted attention for their role in the etiology of numerous respiratory disorders such as cystic fibrosis, bronchial asthma, and acute hypoxemic respiratory failure. However, information regarding the interrelationship and competition bet...

journal_title：Journal of inorganic biochemistry

authors： Ali I,Khan SN,Chatzicharalampous C,Bai D,Abu-Soud HM

更新日期：2019-08-01 00:00:00

abstract：:The successful design and pre-clicked synthesis of a non-toxic and cytosol trackable carboplatin-like near infrared fluorophore conjugate via strain-promoted azide alkyne cycloaddition (SPAAC) is reported. Reaction of cis-[Pt(2-azidopropane-1,3-diamine)(cbdca)] (cbdca = cyclobutane-1,1-dicarboxylato) and a bicyclo[6.1...

journal_title：Journal of inorganic biochemistry

authors： Kitteringham E,Wu D,Cheung S,Twamley B,O'Shea DF,Griffith DM

更新日期：2018-05-01 00:00:00

abstract：:The pH- and time-dependent reactions of the anticancer drug cisplatin, cis-[PtCl(2)(NH(3))(2)], with the peptides Ac-Gly-Met-Gly-OH, Ac-Ser-Met-OH and Ac-Met-His-OH (Gly=glycyl, Met=methionyl, Ser=seryl, His=histidyl) at 313 K have been investigated by high-performance liquid chromatography, nuclear magnetic resonance...

journal_title：Journal of inorganic biochemistry

authors： Manka S,Becker F,Hohage O,Sheldrick WS

更新日期：2004-11-01 00:00:00

abstract：:Two new homo- and hetero-dinuclear complexes, [Cu(2)L(im)](ClO(4))(3)4H(2)O (1) and [CuZnL(im)](ClO(4))(3)4H(2)O (2) (where Im=1H-1midazole and L=3, 6, 9, 16, 19, 22-hexaaza-6, 19-bis(1H-imidazol-4-ylmethyl)tricycle[22, 2, 2, 2(11,14)]triaconta-1, 11, 13, 24, 27, 29-hexaene) were synthesized and characterized as model...

journal_title：Journal of inorganic biochemistry

authors： Yuan Q,Cai K,Qi ZP,Bai ZS,Su Z,Sun WY

更新日期：2009-08-01 00:00:00

abstract：:We prepared and characterized new iridium(III) complexes: [Ir(NC)2(MPPIP)](PF6) (N-C = 2-phenylpyridine 1; benzo[h]quinolone 2; 1-phenylisoquinolone, 3, MPPIP = 2-(4-(4'-methylpiperazin-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline). MTT (MTT = 3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide) method ...

journal_title：Journal of inorganic biochemistry

authors： Gu Y,Wen H,Bai L,Zhou Y,Zhang H,Tian L,Zhang Y,Hao J,Liu Y

更新日期：2020-11-01 00:00:00

abstract：:Nearly all microbes require iron for growth. The low concentration of iron found in the ocean makes iron acquisition a particularly difficult task. In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake. We report herein the...

journal_title：Journal of inorganic biochemistry

authors： Gauglitz JM,Zhou H,Butler A

更新日期：2012-02-01 00:00:00

abstract：:The plasmid DNA scission by the restriction enzyme HaeIII was investigated in the presence of tetrakis(1-methylpyridinium-4-yl)porphyrin (H2TMPyP) and its manganese(III), iron(III), nickel(II), cobalt(III) and zinc(II) derivatives. The effect of metalloporphyrins on plasmid DNA cleavage was ascertained by gel electrop...

journal_title：Journal of inorganic biochemistry

authors： Tabata M,Nakajima K,Nyarko E

更新日期：2000-03-01 00:00:00

abstract：:The non-covalent binding of [(en)Pt(mu-dpzm)2Pt(en)]4+ to segments of DNA containing only G and C bases has been studied to gain an understanding of the pre-covalent binding association of cationic polynuclear platinum(II) anti-cancer drugs at G/C sites. 1H-NMR and CD spectroscopy were used to study the binding of the...

journal_title：Journal of inorganic biochemistry

authors： Wheate NJ,Cutts SM,Phillips DR,Aldrich-Wright JR,Collins JG

更新日期：2001-03-01 00:00:00

abstract：:L-Cysteinatogold(I) was prepared by the reaction of L-cysteine with KAuBr4 in acidic media and its solubility determined from pH 4 to 10. The solubility at pH 7.4 and 37 degrees C is 1 microM. In the presence of excess cysteine, the solubility increases because of formation of bis(L-cysteinato)gold(I). The equilibrium...

journal_title：Journal of inorganic biochemistry

authors： Shaw CF 3rd,Schmitz G,Thompson HO,Witkiewicz P

更新日期：1979-07-01 00:00:00

abstract：:Zinc is an essential element for nutrition as well as for the proper development and function of brain cells, and its traces are present in a wide range of foods. It is a constituent of many enzyme systems and is an integral part of insulin and of the active site of intracellular enzymes. However, excessive accumulati...

journal_title：Journal of inorganic biochemistry

authors： Suwalsky M,Novoa V,Villena F,Sotomayor CP,Aguilar LF,Ronowska A,Szutowicz A

更新日期：2009-05-01 00:00:00

abstract：:The pre-steady-state reduction of cytochrome P450 (P450) 2B4 by P450 reductase (reductase) was modeled by assuming that an equilibrium between three catalytic conformers of P450 regulates the multi-phasic reduction of the enzyme. This model was compared to a model of reduction involving a minimum number of phases. Bas...

journal_title：Journal of inorganic biochemistry

authors： Reed JR,Hollenberg PF

更新日期：2003-11-01 00:00:00

abstract：:The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system,...

journal_title：Journal of inorganic biochemistry

authors： Mondelli M,Bruné V,Borthagaray G,Ellena J,Nascimento OR,Leite CQ,Batista AA,Torre MH

更新日期：2008-02-01 00:00:00

abstract：:Aggregation of amyloid β-proteins (Aβ) induced by Cu2+ is a crucial element in the pathogenesis of Alzheimer's disease (AD), and cerebral acidosis is a common complication of AD. Under mildly acidic conditions, Cu2+-Aβ species have higher tendency to generate neurotoxic aggregates. Hence it is of significance to devel...

journal_title：Journal of inorganic biochemistry

authors： Xie B,Liu F,Dong X,Wang Y,Liu XM,Sun Y

更新日期：2017-06-01 00:00:00

abstract：:The basic knowledge about biological inorganic chemistry, thermodynamics and metal binding sites of metalloproteins is crucial for the understanding of their metal binding-structure-function relationship. Metal-peptide complexes are useful and commonly used models of metal-enzyme active sites, among which copper and z...

journal_title：Journal of inorganic biochemistry

authors： Kołkowska P,Hecel A,Kędzierska D,Ostrowska M,Walencik PK,Wątły J,Zdyb K,Spodzieja M,Rodziewicz-Motowidło S,Potocki S,Łuczkowski M,Gumienna-Kontecka E,Rowińska-Żyrek M

更新日期：2016-10-01 00:00:00

abstract：:Copper(II) complexes supported by N3-tridentate ligands, consisting of a rigid cyclic diamine (8-membered cyclic-diamine; L8 or 7-membered cyclic-diamine; L7) and a 2-(2-pyridyl)ethyl (-CH2CH2Py) group, were synthesized and structurally characterized. Reaction of the copper(II) complexes and cumene hydroperoxide (CmOO...

journal_title：Journal of inorganic biochemistry

authors： Abe T,Morimoto Y,Mieda K,Sugimoto H,Fujieda N,Ogura T,Itoh S

更新日期：2017-12-01 00:00:00

abstract：:The dinuclear complex [Zn(2)(DPCPMP)(pivalate)](ClO4), where DPCPMP is the new unsymmetrical ligand [2-(N-(3-((bis((pyridin-2-yl)methyl)amino)methyl)-2-hydroxy-5-methylbenzyl)-N-((pyridin-2-yl)methyl)amino)acetic acid], has been synthesized and characterized. The complex is a functional model for zinc phosphoesterases...

journal_title：Journal of inorganic biochemistry

authors： Das B,Daver H,Pyrkosz-Bulska M,Persch E,Barman SK,Mukherjee R,Gumienna-Kontecka E,Jarenmark M,Himo F,Nordlander E

更新日期：2014-03-01 00:00:00

abstract：:The coordination geometry around copper(II) in [Cu(imda)(phen)(H2O)] (1) (H2imda = iminodiacetic acid, phen = 1,10-phenanthroline) is described as distorted octahedral while those in [Cu(imda)(5,6-dmp)] (2) (5,6-dmp = 5,6-dimethyl-1,10-phenanthroline) and [Cu(imda)(dpq)] (3) (dpq = dipyrido-[3,2-d:2',3'-f]-quinoxaline...

journal_title：Journal of inorganic biochemistry

authors： Selvakumar B,Rajendiran V,Uma Maheswari P,Stoeckli-Evans H,Palaniandavar M

更新日期：2006-03-01 00:00:00

abstract：:In heme peroxidases, a distal His residue plays an essential role in the initial two electron oxidation of resting state enzyme to compound I by hydrogen peroxide. A distal Arg residue assists in this process. The contributions of the charge, H-bonding capacity, size, and mobility of this Arg residue to Coprinus ciner...

journal_title：Journal of inorganic biochemistry

authors： Schiødt CB,Veitch NC,Welinder KG

更新日期：2007-02-01 00:00:00

abstract：:A series of arene ruthenium(II) complexes with the general formula [(η(6)-arene)Ru(L)X2] (where arene=p-cymene, benzene, hexamethylbenzene or mesitylene, L=aminoflavone or aminochromone derivatives and X=Cl, I) were synthesized and characterized by elemental analysis, MS, IR and (1)H NMR spectroscopy. The stability of...

journal_title：Journal of inorganic biochemistry

authors： Pastuszko A,Majchrzak K,Czyz M,Kupcewicz B,Budzisz E

更新日期：2016-06-01 00:00:00

abstract：:The energy diagram for the catalytic cycle of dioxygen evolution in photosystem II has been recomputed using a slightly different model than the one used previously, since the results showed an erroneous trend in the critical region from S(2) to S(3). By replacing the bicarbonate ligand, which was bridging between cal...

journal_title：Journal of inorganic biochemistry

authors： Siegbahn PE,Lundberg M

更新日期：2006-05-01 00:00:00

abstract：:Horse spleen ferritin (HoSF) reconstituted with small iron cores ranging in size from 8 to 500 iron atoms was studied by magnetic susceptibility and pH measurements to determine when the added Fe3+ begins to aggregate and form antiferromagnetically coupled clusters and also to determine the hydrolytic state of the iro...

journal_title：Journal of inorganic biochemistry

authors： Hilty S,Webb B,Frankel RB,Watt GD

更新日期：1994-11-15 00:00:00