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Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF).

Abstract：

:Human metallothionein-3 (hMT3), also named as human neuronal growth inhibitory factor (hGIF), can inhibit the outgrowth of embryonic cortical neurons in the presence of brain extracts. In order to systematically study the structure-property-reactivity-function relationship of hGIF, our laboratory designed a series of mutants and studied their structure, property, reactivity and functions by a series of chemical and biological tools including UV spectroscopy, CD spectroscopy, NMR, chemical reaction and primary neuronal culture assays. In summary, we concluded that the bioactivity of hGIF was regulated by multiple factors, including the (6)CPCP(9) motif, an additional threonine insert at sequence position 5, domain-domain interactions, the structure and stability of the metal-thiolate cluster and the linker. Our studies provide more and more evidences which revealed that the bioactivity of hGIF is mainly related to the essential metal release and its characteristic conformation.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Ding ZC,Zheng Q,Cai B,Ni FY,Yu WH,Teng XC,Gao Y,Liu F,Chen D,Wang Y,Wu HM,Sun HZ,Zhang MJ,Tan XS,Huang ZX

doi

10.1016/j.jinorgbio.2008.07.007

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1965-72

issue

11

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(08)00172-4

journal_volume

102

pub_type

杂志文章,评审

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