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The second generation of iodido complexes: trans-[PtI2(amine)(amine')] bearing different aliphatic amines.

Abstract：

:The antitumoral potential for a series of platinum iodido complexes, all bearing the same aliphatic amines (first iodido complexes generation), was demonstrated in a previous study. Concretely, cis complexes were shown to have a peculiar and different reactivity compared to cisplatin with sulfur donors models and Cyt C. In this work we have synthesized and studied iodido complexes bearing different aliphatic amines in trans configuration (the second generation) to investigate their potential antitumor activity in a panel of cell lines. Their interaction with biological models such as pBR322 and smaller biomolecules (5'-GMP, 9EtG, N-AcMet and N-AcCys) have been studied and compared to cisplatin and to the first iodido series. Their cytotoxicity, on the other hand, turned out to be especially active towards cell lines where cisplatin has no effect.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Parro T,Medrano MA,Cubo L,Muñoz-Galván S,Carnero A,Navarro-Ranninger C,Quiroga AG

doi

10.1016/j.jinorgbio.2013.04.010

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

182-7

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(13)00101-3

journal_volume

127

pub_type

杂志文章

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