Abstract:
:An overview is given of the results of metal ion-diclofenac interactions. Several complexes have been synthesized at the University of Ioannina. Binuclear complexes, [Cu(L)2(H2O)]2 x 2H2O and [CuL2(S)]2 where S is H2O, EtOH, DMSO, (CH3)2CO and DMF, and mononuclear complexes, [MnL2(H2O)], [FeL2(H2O)2], [CoL2(H2O)2] x 0.5H2O, [CoL2(H2O)], [NiL2(H2O)2] x 2H2O, [NiL2] and [PdL2] x 2H2O, have been characterized by spectroscopy, X-ray crystallography and electrochemical studies. The catalytic activity of these complexes was correlated to the reduction potential. Some of the complexes of diclofenac exhibit very promising anti-inflammatory activity and act as antioxidant compounds, a property that is absent from diclofenac.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Kovala-Demertzi Ddoi
10.1016/s0162-0134(99)00175-0subject
Has Abstractpub_date
2000-04-01 00:00:00pages
153-7issue
1-4eissn
0162-0134issn
1873-3344pii
S0162-0134(99)00175-0journal_volume
79pub_type
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