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Quercetin as a shuttle for labile iron.

Abstract：

:The antioxidant activity of flavonoids may involve their ability to complex body iron in non-redox-active forms. In this study, it was found that the catechol flavonoids rutin and quercetin are able to suppress redox-active labile plasma iron (LPI) in both buffered solution and in iron-overloaded sera. Both flavonoids are effective in loading the metal into the iron-transport protein transferrin. Iron derivatives of quercetin and rutin are able to permeate cell membranes, however, only free quercetin is able to gain access to the cytosol and decrease intracellular labile iron pools. These results suggest that the antioxidant activity of quercetin may be dependent on its ability to shuttle labile iron from cell compartments followed by its transfer to transferrin.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Baccan MM,Chiarelli-Neto O,Pereira RM,Espósito BP

doi

10.1016/j.jinorgbio.2011.11.014

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

34-9

issue

1

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(11)00348-5

journal_volume

107

pub_type

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