当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Peroxidase-like activities of iron(III)-porphyrins: kinetics of the reduction of a peroxidatically active derivative of deuteroferriheme by phenols.

Peroxidase-like activities of iron(III)-porphyrins: kinetics of the reduction of a peroxidatically active derivative of deuteroferriheme by phenols.

Abstract：

:The kinetics of reduction of a peroxidatically active intermediate (formed by reaction of deuteroferriheme with hydrogen peroxide) by phenol and a series of substituted phenols have been studied by stopped-flow spectrophotometry. The complex effects of varying heme concentration have been interpreted in terms of the formation of a dimeric form of the intermediate by reaction of monomeric intermediate with unoxidized ferriheme monomer. Both the relative reactivity of phenols towards the two forms of the intermediate and the rate constants for reduction of intermediate are markedly influenced by phenol substituents. Effects of pH suggest that phenolate anions are the reactive forms of the reductants. Rate constants for the monomeric intermediate reactions (kDFH) are related to those (kHRP) for the corresponding reductions of horseradish peroxidase Compound I by the following relation: log kDFH = 1.53 log kHRP -3.74.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Jones P,Mantle D,Wilson I

doi

10.1016/s0162-0134(00)80090-2

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

293-304

issue

4

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(00)80090-2

journal_volume

17

pub_type

杂志文章

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