Superoxide dismutase inhibition of alkaline hemin-mediated O2 activation.

Abstract:

:Inhibition of hemin-mediated O2 activation by bovine superoxide dismutase and the copper tetrammine complex has been examined. It is shown that the inhibitory effect of these species is not due to metabolism of O2-., but to a nonspecific inhibition of the process by the Cu2+ ion. We propose that the inhibition occurs at the level of electron transfer from NADH to iron in an analogous manner to that proposed for the Cu2+ inhibition of microsomal electron transfer.

journal_name

J Inorg Biochem

authors

Adams C,Adams PA

doi

10.1016/0162-0134(89)80026-1

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

29-34

issue

1

eissn

0162-0134

issn

1873-3344

pii

0162-0134(89)80026-1

journal_volume

37

pub_type

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