An EXAFS study of the zinc sites in sheep liver metallothionein.

abstract：:Metallodrugs have become an integral part of modern medicinal chemistry with platinum drugs as anti-cancer agents being well-known examples. The historically interesting compound Zeise's salt, potassium trichlorido(ethene)platinate(II) has scarcely been investigated in this context yet. This study is geared towards sh...

journal_title：Journal of inorganic biochemistry

authors： Cziferszky M,Gust R

更新日期：2018-12-01 00:00:00

abstract：:New water soluble, enantiopure arene ruthenium compound SRuSN-(1R,4S)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (Bn = benzyl, 1a') has been synthesized. The novel compound along with that previously described RRuRN-(1S,4R)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (1a) was evaluated by polarimetry, ultra-violet and circular dichr...

journal_title：Journal of inorganic biochemistry

authors： de la Cueva-Alique I,Sierra S,Muñoz-Moreno L,Pérez-Redondo A,Bajo AM,Marzo I,Gude L,Cuenca T,Royo E

更新日期：2018-06-01 00:00:00

abstract：:Iron is an essential nutrient for most bacteria. Depending on the oxygen available in the surrounding environment, iron is found in two distinct forms: ferrous (Fe(II)) or ferric (Fe(III)). Bacteria utilize different transport systems for the uptake of the two different forms of iron. In oxic growth conditions, iron i...

journal_title：Journal of inorganic biochemistry

authors： Carpenter C,Payne SM

更新日期：2014-04-01 00:00:00

abstract：:In an effort to understand the biochemical mechanisms of aluminum-induced neurotoxicity, we investigated the effects of aluminum ion, Al3+, on the Mg(2+)- and nucleotide-dependent protein, ras p21. Picomolar Al3+ concentrations inhibited the GTPase activity of ras p21 in an Mg(2+)-dependent manner, consistent with an ...

journal_title：Journal of inorganic biochemistry

authors： Landino LM,Macdonald TL

更新日期：1997-05-01 00:00:00

abstract：:Copper(II) complexes supported by N3-tridentate ligands, consisting of a rigid cyclic diamine (8-membered cyclic-diamine; L8 or 7-membered cyclic-diamine; L7) and a 2-(2-pyridyl)ethyl (-CH2CH2Py) group, were synthesized and structurally characterized. Reaction of the copper(II) complexes and cumene hydroperoxide (CmOO...

journal_title：Journal of inorganic biochemistry

authors： Abe T,Morimoto Y,Mieda K,Sugimoto H,Fujieda N,Ogura T,Itoh S

更新日期：2017-12-01 00:00:00

abstract：:In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl- or NO3-), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e-⇌[CuI(N-N)2]+X-. The disproportion of O2•- was explored in presence of the electro-generated species [CuI(N-N)2]+ ...

journal_title：Journal of inorganic biochemistry

authors： Manzanera-Estrada ME,Cruz-Ramírez M,Flores-Alamo M,Gracia Y Jiménez JM,Galindo-Murillo R,García-Ramos JC,Ruiz-Azuara L,Ortiz-Frade L

更新日期：2017-10-01 00:00:00

abstract：:Since its discovery, nitric oxide synthase (NOS), the enzyme responsible for NO biosynthesis in mammals, has been the subject of extensive investigations regarding its catalytic and molecular mechanisms. These studies reveal the high degree of sophistication of NOS functioning and regulation. However, the precise desc...

journal_title：Journal of inorganic biochemistry

authors： Santolini J

更新日期：2011-02-01 00:00:00

abstract：:Novel chiral Ru(II) complexes [Ru(bpy)2L]2+ (bpy = 2,2-bipyridine; L: o-mopip = 2-(2-methoxylphenyl)imidazo[4,5-f][1,10]phenanthroline, p-mopip = 2-(4-methoxylphenyl)imidazo[4,5-f][1,10]phenanthroline) containing -OCH3 at different positions on the phenyl ring have been synthesized and characterized. The DNA-binding a...

journal_title：Journal of inorganic biochemistry

authors： Shi S,Liu J,Li J,Zheng KC,Huang XM,Tan CP,Chen LM,Ji LN

更新日期：2006-03-01 00:00:00

abstract：:The low-molecular weight water-soluble Fe(III) and Mn(III) porphyrins--in biologically relevant phosphate-buffered saline medium with ascorbic acid as a source of electrons, under aerobic conditions but without co-oxidant - catalyze the hydroxylation of anti-cancer drug cyclophosphamide to active metabolite 4-hydroxyc...

journal_title：Journal of inorganic biochemistry

authors： Spasojević I,Colvin OM,Warshany KR,Batinić-Haberle I

更新日期：2006-11-01 00:00:00

abstract：:A new ligand, N,N'-dibenzylethane-1,2-diamine (L) and its four transition metal(II) complexes, ML(2)(OAc)(2).2H(2)O (M=Cu, Ni, Zn, Co), have been synthesized and characterized by elemental analysis, mass spectra, molar conductivity, NMR and IR. Moreover, the crystals structure of Cu(II) and Ni(II) complexes characteri...

journal_title：Journal of inorganic biochemistry

authors： Wu SS,Yuan WB,Wang HY,Zhang Q,Liu M,Yu KB

更新日期：2008-11-01 00:00:00

abstract：:Ten new vanadocene complexes bearing N,N'-chelating ligands were prepared, characterized, and their cytotoxicity toward a panel of cancer cells was measured. Structures of four vanadocene compounds were determined by single crystal X-ray diffraction analysis. Complexes containing 1,2-bis(phenylimino)acenaphthene (bian...

journal_title：Journal of inorganic biochemistry

authors： Melounková L,Machálková A,Havelek R,Honzíček J,Řezáčová M,Císařová I,Peterová E,Vinklárek J

更新日期：2019-06-01 00:00:00

abstract：:Tree laccase, a multi-copper oxidase, has been studied as a copper donor in conjunction with the demetalated forms of three blue copper proteins. Copper transfer could be observed under reducing conditions in the absence of air. Only about 10% of the total copper in laccase could be transferred regardless of the amoun...

journal_title：Journal of inorganic biochemistry

authors： Meadows KA,Morie-Bebel MM,McMillin DR

更新日期：1991-03-01 00:00:00

abstract：:Bovine calmodulin, spin-labeled at tyrosine-99, has been utilized in electron paramagnetic resonance (EPR) studies to investigate calmodulin interactions with Ca(II), Cd(II), and Mg(II). The addition of either Ca(II) or Cd(II) to apo-calmodulin results in a complex capable of activating target enzymes, such as 3', 5'-...

journal_title：Journal of inorganic biochemistry

authors： You GF,Buccigross JM,Nelson DJ

更新日期：1990-02-01 00:00:00

abstract：:Previous studies of the interaction of the haem undecapeptide (MP-11) with lipidated human serum albumin in aqueous solution have been extended to a range of MeOH/H2O solution compositions. It is demonstrated that the kinetic mechanism for the interaction does not change from a simple second- and first-order reversibl...

journal_title：Journal of inorganic biochemistry

authors： Adams PA,Thumser AE

更新日期：1993-04-01 00:00:00

abstract：:In this work we present results of density functional theory (DFT) calculations on dicopper patellamides and their affinity for molecular oxygen and carbonate. Patellamides are cyclic octapeptides that are produced by a cyanobacterium, and may show promise as therapeutics. Thus, carbonate binding to a dicopper patella...

journal_title：Journal of inorganic biochemistry

authors： Latifi R,Bagherzadeh M,Milne BF,Jaspars M,de Visser SP

更新日期：2008-12-01 00:00:00

abstract：:Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray ...

journal_title：Journal of inorganic biochemistry

authors： Ahmad Khan R,Al-Farhan K,de Almeida A,Alsalme A,Casini A,Ghazzali M,Reedijk J

更新日期：2014-11-01 00:00:00

abstract：:Three Pt(II) complexes containing the natural ligands curcumin and caffeine, namely [Pt(curc)(PPh3)2]Cl (1), [PtCl(curc)(DMSO)] (2) (curc = deprotonated curcumin) and trans-[Pt(caffeine)Cl2(DMSO)] (3), were synthesized and fully characterized. The data obtained suggest that, for both 1 and 2, the anion of curcumin is ...

journal_title：Journal of inorganic biochemistry

authors： Censi V,Caballero AB,Pérez-Hernández M,Soto-Cerrato V,Korrodi-Gregório L,Pérez-Tomás R,Dell'Anna MM,Mastrorilli P,Gamez P

更新日期：2019-09-01 00:00:00

abstract：:The pre-steady-state reduction of cytochrome P450 (P450) 2B4 by P450 reductase (reductase) was modeled by assuming that an equilibrium between three catalytic conformers of P450 regulates the multi-phasic reduction of the enzyme. This model was compared to a model of reduction involving a minimum number of phases. Bas...

journal_title：Journal of inorganic biochemistry

authors： Reed JR,Hollenberg PF

更新日期：2003-11-01 00:00:00

abstract：:We have studied the electron paramagnetic resonance (epr) spectra of complexes of apo-yeast enolase with 65Cu+2 in the presence and absence of substrate and magnesium ion. An unusual epr spectrum with large g parallel, large g and A rhombicity and very narrow line-widths (10 G) is seen for the first two 65Cu+2 bound i...

journal_title：Journal of inorganic biochemistry

authors： Dickinson LC,Rose SL,Westhead EW

更新日期：1980-12-01 00:00:00

abstract：:The pH dependence of the apparent affinity constants of perchlorate for cobalt(II)bovine carbonic anhydrase II has been measured by electronic absorption spectroscopy. The obtained data have been analyzed in terms of the ionization of two acidic groups of CoBCAII, and the affinity of perchlorate for the two water-cont...

journal_title：Journal of inorganic biochemistry

authors： Moratal JM,Martínez-Ferrer MJ,Donaire A,Aznar L

更新日期：1992-01-01 00:00:00

abstract：:1,2-diolato ligands, such as carbohydrates and glycoproteins, tend to stabilize chromium(V), thus forming important intermediates that have been implicated in the genotoxicity of Cr(VI). Since many years, room-temperature continuous-wave electron paramagnetic resonance (EPR) at X-band microwave frequencies has been us...

journal_title：Journal of inorganic biochemistry

authors： Van Doorslaer S,Beirinckx Q,Nys K,Mangiameli MF,Cuypers B,Callens F,Vrielinck H,González JC

更新日期：2016-09-01 00:00:00

abstract：:The reaction of Mycobacterium tuberculosis KatG and the mutant KatG(S315T) with two different organic peroxides is studied using resonance Raman spectroscopy. For the first time, an intermediate is observed in a catalase-peroxidase with vibrations that are characteristic of Compound II. The observation of this interme...

journal_title：Journal of inorganic biochemistry

authors： Kapetanaki SM,Chouchane S,Yu S,Magliozzo RS,Schelvis JP

更新日期：2005-06-01 00:00:00

abstract：:The antitumoral potential for a series of platinum iodido complexes, all bearing the same aliphatic amines (first iodido complexes generation), was demonstrated in a previous study. Concretely, cis complexes were shown to have a peculiar and different reactivity compared to cisplatin with sulfur donors models and Cyt ...

journal_title：Journal of inorganic biochemistry

authors： Parro T,Medrano MA,Cubo L,Muñoz-Galván S,Carnero A,Navarro-Ranninger C,Quiroga AG

更新日期：2013-10-01 00:00:00

abstract：:With the aim to investigate the mechanism of Cu(I) transport by Wilson ATPase (ATP7B), we have studied the interaction of the peptides 2K10p (CH(3)CO-Lys-Gly-Met-Thr-Cys-Ala-Ser-Cys-Val-His-Asn-Lys-CONH(2)), and 2K8p (CH(3)CO-Lys-Leu-Cys-Ile-Ala-Cys-Pro-Cys-Ser-Lys-CONH(2)), part of the sixth metal binding domain (WD6...

journal_title：Journal of inorganic biochemistry

authors： Myari A,Hadjiliadis N,Fatemi N,Sarkar B

更新日期：2004-09-01 00:00:00

abstract：:A series of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines has been prepared. The complexes have the following composition: cis-[Pt(Boh)(2)Cl(2)] (1), cis-[Pt(Oc)(2)Cl(2)] (2), cis-[Pt(Ros)(2)Cl(2)] (3), cis-[Pt(i-PrOc)(2)Cl(2)] (4), cis-[Pt(BohH(+))(2)Cl(2)]Cl(2) (5), cis-[Pt(OcH(+))(2)Cl(2)]Cl(2)...

journal_title：Journal of inorganic biochemistry

authors： Malon M,Trávnícek Z,Marek R,Strnad M

更新日期：2005-11-01 00:00:00

abstract：:The non-covalent binding of [(en)Pt(mu-dpzm)2Pt(en)]4+ to segments of DNA containing only G and C bases has been studied to gain an understanding of the pre-covalent binding association of cationic polynuclear platinum(II) anti-cancer drugs at G/C sites. 1H-NMR and CD spectroscopy were used to study the binding of the...

journal_title：Journal of inorganic biochemistry

authors： Wheate NJ,Cutts SM,Phillips DR,Aldrich-Wright JR,Collins JG

更新日期：2001-03-01 00:00:00

abstract：:A series of new 3d metal complexes with 5-chloro-quinolin-8-ol (ClQ), [Mn(ClQ)2] (1), [Fe(ClQ)3] (2), [Co(ClQ)2(H2O)2] (3), [Ni(ClQ)2(H2O)2] (4), [Cu(ClQ)2] (5), [Zn(ClQ)2(H2O)2] (6), [Mn(ClQ)3]·DMF (7) and [Co(ClQ)3]·DMF·(EtOH)0.35 (8) (DMF=N,N-dimethylformamide), has been synthesized and characterized by elemental a...

journal_title：Journal of inorganic biochemistry

authors： Potočňák I,Vranec P,Farkasová V,Sabolová D,Vataščinová M,Kudláčová J,Radojević ID,Čomić LR,Markovic BS,Volarevic V,Arsenijevic N,Trifunović SR

更新日期：2016-01-01 00:00:00

abstract：:The N-terminal protected and unprotected peptides MAHHEEQHG-NH(2), Ac-MAHHEEQHG-NH(2) from Hpn (Helicobacter histidine-rich protein) and MAHHEQQQQQQA-NH(2), Ac-MAHHEQQQQQQA-NH(2) from Hpn-like protein, respectively, were synthesized and their interactions with Cu(2+) and Ni(2+) ions were studied by potentiometric, UV-...

journal_title：Journal of inorganic biochemistry

authors： Witkowska D,Bielinska S,Kamysz W,Kozlowski H

更新日期：2011-02-01 00:00:00

abstract：:Zincon (ZI) is one of the most common chromophoric chelating probes for the determination of Zn2+ and Cu2+ ions. It is also known to bind other metal ions. However, literature data on its binding properties and molar absorption coefficients are rather poor, varying among publications or determined only in certain cond...

journal_title：Journal of inorganic biochemistry

authors： Kocyła A,Pomorski A,Krężel A

更新日期：2017-11-01 00:00:00

abstract：:Carboxypeptidase A-catalyzed hydrolysis of peptides and depsipeptides is competitively inhibited by N-(1-carboxy-5-t-butyloxycarbonylaminopentyl)-L-phenylalanine (Boc-CA-Phe, Ki = 1.3 microM) and the angiotensin converting enzyme inhibitor, N-(1-carboxy-5-carbobenzoxyaminopentyl)-glycyl-L-phenylalanine (Z-CA-Gly-Phe, ...

journal_title：Journal of inorganic biochemistry

authors： Martin MT,Holmquist B,Riordan JF

更新日期：1989-05-01 00:00:00