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Copper(II) inhibits the formation of amylin amyloid in vitro.

Abstract：

:The amyloidogenic peptide amylin is found associated with pancreatic islet beta-cells and is implicated in the aetiology of type-2 diabetes mellitus. We have used fluorimetry and transmission electron microscopy to investigate in vitro the influence of Al(III), Fe(III), Zn(II) and Cu(II) on amylin amyloid formation under near-physiological conditions. Cu(II) at 10.0 microM inhibited amylin of 0.4 and 2.0 microM from forming amyloid fibrils while the same concentration of either Al(III) or Zn(II) promoted the formation of beta-pleated sheet structures. If amylin amyloid is cytotoxic to beta-cells then Cu(II) should protect against the degeneration of the islets in type-2 diabetes mellitus.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Ward B,Walker K,Exley C

doi

10.1016/j.jinorgbio.2007.09.010

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

371-5

issue

2

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(07)00276-0

journal_volume

102

pub_type

杂志文章

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