当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes.

Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes.

Abstract：

:The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)(2)(L)](ClO(4))(2) complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal-bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometric measurements. Testing copper(II) complexes in mouse neuroblastoma N2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Pivetta T,Cannas MD,Demartin F,Castellano C,Vascellari S,Verani G,Isaia F

doi

10.1016/j.jinorgbio.2010.11.017

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

329-38

issue

3

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(10)00270-9

journal_volume

105

pub_type

杂志文章

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