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Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity.

Abstract：

:Glutaredoxins (Grxs) are ubiquitous thioltransferases and members of the thioredoxin (Trx) fold superfamily. They have multiple functions in cells including oxidative stress responses and cell signaling. A novel glutaredoxin from buckwheat (rbGrx) with higher catalytic activity was identified, cloned, and purified. The structures of glutathionylated rbGrx and an rbGrx mutant, in which cysteine 39 was mutated to alanine, were solved by x-ray diffraction at a resolution of 2.05Å and 2.29Å, respectively. In rbGrx, GSH (glutathione) is bound at the conserved GSH-binding site, and its structure shows that it has the potential to function as a scaffold protein for the assembly and delivery of GSH. The crystal structure shows that GSH does not bind to the C39A rbGrx mutant, and the C39A mutant had no catalytic activity, indicating that C39 is a key residue that is involved in both the binding of rbGrx to GSH and the regulation of its catalytic activity. The model showing the binding of GSH with rbGrx provides a basis for understanding its molecular function and its potential future applications in medicinal food science.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Zhang X,Wang W,Li C,Zhao Y,Yuan H,Tan X,Wu L,Wang Z,Wang H

doi

10.1016/j.jinorgbio.2017.04.019

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

21-27

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(16)30482-2

journal_volume

173

pub_type

杂志文章

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