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Renal handling of amino acid 99mtechnetium chelates.

Abstract：

:Four amino acids--alanine, 2,3-diaminopropionic acid, cystine, and cystein--and also one diamine, ethylenediamine, were chelated with 99m-technetium (99mTc), and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and 2,4-dinitrophenol. From the depression of renal excretion for the first three amino acid chelates, in the presence of the inhibitors, a renal tubular excretory pathway of elimination was suggested for these compounds. The renal excretions of 99mTc-cystein and 99mTc-ethylenediamine however, remained undepressed under similar experimental conditions. An explanation of these observations was forwarded from the possible chemical structures of these chelates.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Chattopadhyay M,Banerjee S

doi

10.1016/0162-0134(88)85015-3

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

25-40

issue

1

eissn

0162-0134

issn

1873-3344

pii

0162-0134(88)85015-3

journal_volume

34

pub_type

杂志文章

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