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Changes in poly[d(T-G).d(C-A)] chirality due to Hg(II)-binding: circular dichroism (CD) studies.

Abstract：

:The conformation of poly[d(T-G).d(C-A)] in aqueous solution (0.1 M NaClO4, 5 mM cacodylic acid buffer, pH 6.9) was studied by circular dichroism (CD) spectroscopy in the ultraviolet. The conformation of the polynucleotide, as reflected by its chiroptical signature, changes in a highly cooperative fashion in the presence of Hg(ClO4)2. The CD changes signal transitions first from the B to a modified B-state (B*), or to a non-B structure termed X, and finally to a form that is presumably Z. The alterations are totally reversible subsequent to the removal of mercury with the help of a suitable complexing agent such as sodium cyanide, indicating that mercuration does not disrupt Watson-Crick hydrogen bonding to any extent.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Gruenwedel DW,Cruikshank MK

doi

10.1016/0162-0134(91)84066-i

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

29-36

issue

1

eissn

0162-0134

issn

1873-3344

pii

0162-0134(91)84066-I

journal_volume

43

pub_type

杂志文章

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