Derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5' AMP. Use as enzymatic labels with glycogen phosphorylase B.

Abstract:

:Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5' AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy. The activities of these complexes as substitutes of 5' AMP as allosteric activators of glycogen phosphorylase b have been tested. The derivatives that have no interaction with the phosphate group are good analogs of the natural allosteric activator; the complexes that have direct bonding between metallic ion and phosphate groups do not activate the enzyme.

journal_name

J Inorg Biochem

authors

Puig P,Terron A,Moreno V

doi

10.1016/0162-0134(85)80011-8

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

175-85

issue

3

eissn

0162-0134

issn

1873-3344

pii

0162-0134(85)80011-8

journal_volume

25

pub_type

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