Inhibition of human topoisomerase II by the antitumor metallocenes.

abstract：:Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of...

journal_title：Journal of inorganic biochemistry

authors： Crisponi G,Nurchi VM,Pivetta T,Gałezowska J,Gumienna-Kontecka E,Bailly T,Burgada R,Kozłowski H

更新日期：2008-07-01 00:00:00

abstract：:A previous publication [Frenkel, Cain, and Chao, Biochem. Biophys. Res. Commun. 127, 849-856 (1985)] described the observation that double-stranded DNA which was briefly exposed to methyl mercury (MeHg) and purified to remove free methyl mercury was transcribed at a higher rate by RNA polymerase II from wheat germ. Th...

journal_title：Journal of inorganic biochemistry

authors： Frenkel GD,Wilson H,Ducote J

更新日期：1986-06-01 00:00:00

abstract：:New heteroditopic, bi- and multidentate imino- and aminophosphine ligands were synthesised and complexed to [AuCl(THT)] (THT=tetrahydrothiophene). X-ray crystallography confirmed Schiff base formation in three products, the successful reduction of the imino-group to the sp(3)-hybridised amine in several instances, and...

journal_title：Journal of inorganic biochemistry

authors： Traut-Johnstone T,Kanyanda S,Kriel FH,Viljoen T,Kotze PD,van Zyl WE,Coates J,Rees DJ,Meyer M,Hewer R,Williams DB

更新日期：2015-04-01 00:00:00

abstract：:Subcellular fractions were prepared by differential centrifugation from heart and liver of a lamb labeled with 75Se-selenite. Crude fractions of nuclei, mitochondria, and microsomes from both tissues were solubilized with sodium dodecyl sulfate and chromatographed on columns of sephacryl S-200. A low molecular weight ...

journal_title：Journal of inorganic biochemistry

authors： Beilstein MA,Tripp MJ,Whanger PD

更新日期：1981-12-01 00:00:00

abstract：:Bacteria have developed multiple resistance mechanisms against the most used antibiotics. In particular, zinc-dependent metallo-β-lactamase producing bacteria are a growing threat, and therapeutic options are limited. Zinc chelators have recently been investigated as metallo-β-lactamase inhibitors, as they are often a...

journal_title：Journal of inorganic biochemistry

authors： La Piana L,Viaggi V,Principe L,Di Bella S,Luzzaro F,Viale M,Bertola N,Vecchio G

更新日期：2021-02-01 00:00:00

abstract：:Three biotinylated platinum(IV) complexes (1-3) were designed and synthesized. The resulting platinum(IV) complexes exhibited effective cytotoxicity against the tested cancer cell lines, especially complex 1, which was 2.0-9.6-fold more potent than cisplatin. These complexes were found to be rapidly reduced to their a...

journal_title：Journal of inorganic biochemistry

authors： Zhao J,Hua W,Xu G,Gou S

更新日期：2017-11-01 00:00:00

abstract：:Aiming to investigate the use of tridentate ligands to develop new bireductively activated prodrugs, two N(2)O-donor ligands (HL1: [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine; and HL2: [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were used to synthesize new Co(III) complexes, 1 and 2. Both complexes were chara...

journal_title：Journal of inorganic biochemistry

authors： Souza ET,Castro LC,Castro FA,do Canto Visentin L,Pinheiro CB,Pereira MD,de Paula Machado S,Scarpellini M

更新日期：2009-10-01 00:00:00

abstract：:The reactions of hydroquinone with hydrogen peroxide catalyzed by transition metal ions Cu2+, Fe2+, Fe3+, Co2+ and Mn2+ were investigated in aqueous solution at 25 degrees C. Two copper (II) complexes (bis(dimethylglyoxime) copper(II) and 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-dienatocopper(II)...

journal_title：Journal of inorganic biochemistry

authors： Meng XG,Guo Y,Hu CW,Zeng XC

更新日期：2004-12-01 00:00:00

abstract：:The relationship between respiratory and neurological effects of exposure to aluminium (Al) was investigated in a group of foundry workers exposed to Al at concentrations below the threshold limit value (TLV) binding in Poland (2.0 mg Al2O3 m(-3)). Neurological and neurophysiological parameters indicated subclinical e...

journal_title：Journal of inorganic biochemistry

authors： Halatek T,Sinczuk-Walczak H,Rydzynski K

更新日期：2005-09-01 00:00:00

abstract：:The 134 amino acid DNase domain of colicin E9 contains a zinc-finger-like HNH motif that binds divalent transition metal ions. We have used 1D 1H and 2D 1H-15N NMR methods to characterise the binding of Co2+, Ni2+ and Zn2+ to this protein. Data for the Co2+-substituted and Ni2+-substituted proteins show that the metal...

journal_title：Journal of inorganic biochemistry

authors： Hannan JP,Whittaker SB,Hemmings AM,James R,Kleanthous C,Moore GR

更新日期：2000-04-01 00:00:00

abstract：:Four amino acids--alanine, 2,3-diaminopropionic acid, cystine, and cystein--and also one diamine, ethylenediamine, were chelated with 99m-technetium (99mTc), and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and 2,4-dinitropheno...

journal_title：Journal of inorganic biochemistry

authors： Chattopadhyay M,Banerjee S

更新日期：1988-09-01 00:00:00

abstract：:The reactions of Fe(II)EDTA, Fe(II)DTPA, and Fe(II)HEDTA with hydrogen peroxide near neutral pH have been investigated. All these reactions have been assumed to proceed through an active intermediate, I1, (Formula: see text) where pac is one of the three polyaminocarboxylates mentioned above. I1, whether .OH radical o...

journal_title：Journal of inorganic biochemistry

authors： Rush JD,Koppenol WH

更新日期：1987-03-01 00:00:00

abstract：:Dentin remineralization is of clinical relevance in the therapy of caries and dentin hypersensitivity. This study is aimed at gaining more insights on a molecular scale, through IR spectroscopy, into dentin demineralization and remineralization. The dentin demineralization by ethylenediaminetetraacetic acid, EDTA (17%...

journal_title：Journal of inorganic biochemistry

authors： Di Foggia M,Prati C,Gandolfi MG,Taddei P

更新日期：2019-04-01 00:00:00

abstract：:Composites of beta-chitin with calcium carbonate polymorphs were prepared by precipitation of the mineral into a chitin scaffold by means of a double diffusion system. The beta-chitin was obtained from the pen of the Loligo sp. squid. The three main polymorphs of calcium carbonate: aragonite, calcite and vaterite, wer...

journal_title：Journal of inorganic biochemistry

authors： Falini G,Fermani S,Ripamonti A

更新日期：2002-08-30 00:00:00

abstract：:Electron spin resonance spin trapping was utilized to investigate free radical generation from cobalt (Co) mediated reactions using 5,5-dimethyl-1-pyrroline (DMPO) as a spin trap. A mixture of Co with water in the presence of DMPO generated 5,5-dimethylpyrroline-(2)-oxy(1) DMPOX, indicating the production of strong ox...

journal_title：Journal of inorganic biochemistry

authors： Leonard S,Gannett PM,Rojanasakul Y,Schwegler-Berry D,Castranova V,Vallyathan V,Shi X

更新日期：1998-07-01 00:00:00

abstract：:Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold drugs seem to be mediated, mainly, by ...

journal_title：Journal of inorganic biochemistry

authors： Darabi F,Marzo T,Massai L,Scaletti F,Michelucci E,Messori L

更新日期：2015-08-01 00:00:00

abstract：:Oxaliplatin-based chemotherapy is the mainstay for the treatment of advanced colorectal cancer. Copper transporter proteins have been implicated in the transport of platinum-based anticancer drugs, but their expression in human colorectal cancer cell lines and roles in controlling their sensitivity to oxaliplatin are ...

journal_title：Journal of inorganic biochemistry

authors： Cui H,Zhang AJ,McKeage MJ,Nott LM,Geraghty D,Guven N,Liu JJ

更新日期：2017-12-01 00:00:00

abstract：:Series of dinuclear species [Ru(2)(L)(2)(LH)(2)-mu-S(2)Cl(2)], [Ru(2)(L)(2)(LH)(4)-mu-Se(2)Cl(2)] (L=L(1)H and L(3)H) and [Ru(2)(L(2))(2)(L(2)H)-mu-Se(2)Cl(2)].2H(2)O, where L(1)H, L(2)H and L(3)H represent for 2-mercapto-5-phenyl-1,3,4-oxadiazole, 2-mercapto-benzimidazole and 2-mercapto-benzothiazole, respectively, h...

journal_title：Journal of inorganic biochemistry

authors： Mishra L,Vilaplana R,Singh VK,Yadaw AK,González-Vilchez F

更新日期：2001-09-01 00:00:00

abstract：:Bioorganometallic ferrocene-dipeptide conjugates with the Ala-Pro-cysteamine chain, Fc-L-Ala-L-Pro-NHCH2CH2SH (2) and Fc-L-Ala-D-Pro-NHCH2CH2SH (4) (Fc=ferrocenoyl), were prepared by the reduction of the ferrocene-dipeptide conjugates, Fc-L-Ala-L-Pro-cystamine-L-Pro-L-Ala-Fc (1) or Fc-L-Ala-D-Pro-cystamine-D-Pro-L-Ala...

journal_title：Journal of inorganic biochemistry

authors： Moriuchi T,Nishiyama T,Tayano Y,Hirao T

更新日期：2017-12-01 00:00:00

abstract：:Three vanadium complexes of chlorodipicolinic acid (4-chloro-2,6-dipicolinic acid) in oxidation states III, IV, and V were prepared and their properties characterized across the oxidation states. In addition, the series of hydroxylamido, methylhydroxylamido, dimethylhydroxylamido, and diethylhydroxylamido complexes we...

journal_title：Journal of inorganic biochemistry

authors： Smee JJ,Epps JA,Ooms K,Bolte SE,Polenova T,Baruah B,Yang L,Ding W,Li M,Willsky GR,la Cour A,Anderson OP,Crans DC

更新日期：2009-04-01 00:00:00

abstract：:Nickel-containing carbon monoxide dehydrogenases, acetyl-CoA synthases, nickel-iron hydrogenases, and diron hydrogenases are distinct metalloenzymes yet they share a number of important characteristics. All are O(2)-sensitive, with active-sites composed of iron and/or nickel ions coordinated primarily by sulfur ligand...

journal_title：Journal of inorganic biochemistry

authors： Lindahl PA

更新日期：2012-01-01 00:00:00

abstract：:Three new copper(II) complexes of stoichiometry [Cu(L-dipeptide)].nH(2)O, containing as ligands the dipeptides L-alanine-L-isoleucine, L-alanine-L-threonine and L-alanine-L-tyrosine were prepared. They were characterized by single crystal X-ray diffractometry, and electronic and infrared spectroscopy. In all cases, th...

journal_title：Journal of inorganic biochemistry

authors： Facchin G,Torre MH,Kremer E,Piro OE,Castellano EE,Baran EJ

更新日期：2002-04-28 00:00:00

abstract：:The effects of the divalent alkaline-earth metal ions (Ca2+ and Mg2+) on the substrate binding affinity, spin-state transition at the heme active site, conformational properties as well as the stability of the active form of cytochrome P450cam (CYP 101) have been investigated using various spectroscopic and kinetic me...

journal_title：Journal of inorganic biochemistry

authors： Manna SK,Mazumdar S

更新日期：2008-05-01 00:00:00

abstract：:Copper(II) complexes of the peptide fragment (Dpl122-130) encompassing the sequence 122-130 of human doppel protein were characterized by potentiometric, UV-Visible, CD and EPR spectroscopic methods. An analogous peptide, in which the aspartate residue was substituted by an asparagine amino acid, was synthesized in or...

journal_title：Journal of inorganic biochemistry

authors： Mendola DL,Magrì A,Hansson O,Bonomo RP,Rizzarelli E

更新日期：2009-05-01 00:00:00

abstract：:HtaA is a heme-binding protein that is part of the heme uptake system in Corynebacterium diphtheriae. HtaA contains two conserved regions (CR1 and CR2). It has been previously reported that both domains can bind heme; the CR2 domain binds hemoglobin more strongly than the CR1 domain. In this study, we report the bioph...

journal_title：Journal of inorganic biochemistry

authors： Uluisik RC,Akbas N,Lukat-Rodgers GS,Adrian SA,Allen CE,Schmitt MP,Rodgers KR,Dixon DW

更新日期：2017-02-01 00:00:00

abstract：:Cytochrome P450 (P450) of eukaryotes and prokaryotes diversified remarkably during the long course of their evolution. Since the diversification of P450 was the consequence of the adaptation of various living organisms to diverse environmental changes, the catalytic activities and physiological functions of the P450s ...

journal_title：Journal of inorganic biochemistry

authors： Omura T

更新日期：2018-09-01 00:00:00

abstract：:The rational design of anticancer agents that acts in specific biological targets is one of the most effective strategies for developing chemotherapeutic agents. Aiming at obtaining new ruthenium (II) compounds with good cytotoxicity against tumor cells, a series of new complexes of general formula [RuCl(PPh3)(Hdpa)(N...

journal_title：Journal of inorganic biochemistry

authors： Ribeiro GH,Colina-Vegas L,Clavijo JCT,Ellena J,Cominetti MR,Batista AA

更新日期：2019-04-01 00:00:00

abstract：:In this study emission and synchronous-scan fluorescence spectroscopy have been used to investigate the interaction of the class A (oxygen seeking 'hard acid') metal Al(3+), with Suwannee River fulvic acid (SRFA), as well as competition between Al(3+) and several other metal ions (Ca(2+), Mg(2+), Cu(2+), Pd(2+), La(3+...

journal_title：Journal of inorganic biochemistry

authors： Zhao J,Nelson DJ

更新日期：2005-02-01 00:00:00

abstract：:A zinc(II) complex having planar tridentate ligand, bzimpy, where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by UV, NMR, infrared spectroscopy and fluorescence spectra. The zinc complex acts as dibasic acids, in which N-H protons on benzimidazole moieties are responsible for a depr...

journal_title：Journal of inorganic biochemistry

authors： Wang J,Shuai L,Xiao X,Zeng Y,Li Z,Matsumura-Inoue T

更新日期：2005-03-01 00:00:00

abstract：:Two novel pyrazole based thiourea palladium(II) complexes, [PdCl(PPh3)(C9H8NO2S-pz)] (1) and [PdCl(PPh3)(C14H10NO2S-pz)] (2) [pz = pyrazole (C3H2N2)] have been obtained unexpectedly from chromone thiosemicarbazones (L1 and L2) and [PdCl2(PPh3)2]. The compounds have been fully characterized by physicochemical studies. ...

journal_title：Journal of inorganic biochemistry

authors： Haribabu J,Balachandran C,Tamizh MM,Arun Y,Bhuvanesh NSP,Aoki S,Karvembu R

更新日期：2020-04-01 00:00:00