Ternary complexes of Cu(II) ion with cimetidine and L-alanine.

abstract：:The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties. Nowadays, several oxygen sensitive luminescent probes are used to de...

journal_title：Journal of inorganic biochemistry

authors： Belej D,Jurasekova Z,Nemergut M,Wagnieres G,Jancura D,Huntosova V

更新日期：2017-09-01 00:00:00

abstract：:The synthesis, physico-chemical characterization and cytotoxicity against five human tumoral cell lines (THP-1, U937, Molt-4, Colo205 and H460) of three new cobalt(II) coordination compounds are reported (i.e. Co(HL1)Cl (1), Co(HL2)Cl (2) and [Co(HL3)Cl]0.0.5 (CH3)2CHOH (3)). H2L2 (2-{[[2-hydroxy-3-(1-naphthyloxy)prop...

journal_title：Journal of inorganic biochemistry

authors： Morcelli SR,Bull ÉS,Terra WS,Moreira RO,Borges FV,Kanashiro MM,Bortoluzzi AJ,Maciel LL,de A Almeida JC,Júnior AH,Fernandes C

更新日期：2016-08-01 00:00:00

abstract：:When pulsed cytochrome c oxidase is exposed to carbon monoxide in the absence of oxygen the enzyme is converted quickly to its CO-associated mixed valence state. The half-time for this reaction at 0 degree C is about 4 min. This is about 100 times faster than a similar reaction which begins with the resting form of th...

journal_title：Journal of inorganic biochemistry

authors： Morgan JE,Blair DF,Chan SI

更新日期：1985-03-01 00:00:00

abstract：:Subcellular fractions were prepared by differential centrifugation from heart and liver of a lamb labeled with 75Se-selenite. Crude fractions of nuclei, mitochondria, and microsomes from both tissues were solubilized with sodium dodecyl sulfate and chromatographed on columns of sephacryl S-200. A low molecular weight ...

journal_title：Journal of inorganic biochemistry

authors： Beilstein MA,Tripp MJ,Whanger PD

更新日期：1981-12-01 00:00:00

abstract：:A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) co...

journal_title：Journal of inorganic biochemistry

authors： Barbosa ASL,Guedes JS,da Silva DR,Meneghetti SMP,Meneghetti MR,da Silva AE,de Araujo MV,Alexandre-Moreira MS,de Aquino TM,de Siqueira Junior JP,de Araújo RSA,da Cruz RMD,Mendonça-Junior FJB

更新日期：2018-03-01 00:00:00

abstract：:The ability of antitumor active metallocenes Cp2MCl2, (M=Ti, V, Mo, Nb) and the biologically inactive derivative (MeCp)2TiCl2, to inhibit the relaxation of supercoiled plasmid DNA pBR322 by human topoisomerase II has been studied by gel electrophoresis. All metallocenes inhibit the enzyme with maximum inhibition obser...

journal_title：Journal of inorganic biochemistry

authors： Mokdsi G,Harding MM

更新日期：2001-01-15 00:00:00

abstract：:In contrast to the comprehensive structural information about metal complexes with adenine, the corresponding to its isomer 2-aminopurine (H2AP) is extremely poor. With the aim to rationalize the metal binding pattern of H2AP, we report the molecular and/or crystal structure of four novel compounds with various iminod...

journal_title：Journal of inorganic biochemistry

authors： Domínguez-Martín A,Choquesillo-Lazarte D,González-Pérez JM,Castiñeiras A,Niclós-Gutiérrez J

更新日期：2011-08-01 00:00:00

abstract：:Cellular uptake of a drug is one of the most important factors influencing its pharmacodynamics and pharmacokinetics. Our laboratory has previously studied platinum uptake following cisplatin, carboplatin and oxaliplatin treatment at sub-lethal doses of selected tumour cell lines. Here we report on the influence of te...

journal_title：Journal of inorganic biochemistry

authors： Gabano E,Colangelo D,Ghezzi AR,Osella D

更新日期：2008-04-01 00:00:00

abstract：:The results are reported of a potentiometric and spectrophotometric study of the proton and copper(II) complexes of methionine enkephalin and four related pentapeptides which all show greater biological activity than their parent enkephalin. Measurements were carried out at 25 degrees C and I = 0.10 mol dm-3 (KNO3). A...

journal_title：Journal of inorganic biochemistry

authors： Formicka-Kozlowska G,Pettit LD,Steel I,Livera CE,Kupryszewski G,Rolka K

更新日期：1985-08-01 00:00:00

abstract：:Selenium in the form of selenocysteine plays an essential role in a number of proteins, but its role in non-enzymatic biochemistry is also important. In this short review we discuss the interactions between inorganic selenium, arsenic and mercury under physiological conditions, especially in the presence of glutathion...

journal_title：Journal of inorganic biochemistry

authors： Prince RC,Gailer J,Gunson DE,Turner RJ,George GN,Pickering IJ

更新日期：2007-11-01 00:00:00

abstract：:Transition metals, such as Cu(+2), Mn(+2), and Co(+2), have been seen to catalyze the bicarbonate enhanced oxidation of a variety of substrates by H(2)O(2). In several of these cases it has been demonstrated that CO(2), rather than bicarbonate, is the enhancing species. Mechanisms that are in accord with the data invo...

journal_title：Journal of inorganic biochemistry

authors： Liochev SI,Fridovich I

更新日期：2006-04-01 00:00:00

abstract：:Chromium(VI) compounds (e.g. chromates) are cytotoxic, mutagenic, and potentially carcinogenic. The reduction of Cr(VI) can yield reactive intermediates such as Cr(V) and reactive oxygen species. Bronchial epithelial cells are the primary site of pulmonary exposure to inhaled Cr(VI) and are the primary cells from whic...

journal_title：Journal of inorganic biochemistry

authors： Borthiry GR,Antholine WE,Myers JM,Myers CR

更新日期：2008-07-01 00:00:00

abstract：:A large number of proteins contain bound zinc ions. These zinc ions are frequently coordinated by a combination of histidine and cysteine residues. In addition to atoms that coordinate directly to the zinc ions, these side chains have groups that can donate or accept hydrogen bonds from other groups. These secondary i...

journal_title：Journal of inorganic biochemistry

authors： Namuswe F,Berg JM

更新日期：2012-06-01 00:00:00

abstract：:Since its discovery, nitric oxide synthase (NOS), the enzyme responsible for NO biosynthesis in mammals, has been the subject of extensive investigations regarding its catalytic and molecular mechanisms. These studies reveal the high degree of sophistication of NOS functioning and regulation. However, the precise desc...

journal_title：Journal of inorganic biochemistry

authors： Santolini J

更新日期：2011-02-01 00:00:00

abstract：:The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system,...

journal_title：Journal of inorganic biochemistry

authors： Mondelli M,Bruné V,Borthagaray G,Ellena J,Nascimento OR,Leite CQ,Batista AA,Torre MH

更新日期：2008-02-01 00:00:00

abstract：:Manganese peroxidase (MnP) is an extracellular heme enzyme produced by the lignin-degrading white-rot fungus Phanerochaete chrysosporium. MnP catalyzes the peroxide-dependent oxidation of Mn(II) to Mn(III). The Mn(III) is released from the enzyme in complex with oxalate, enabling the oxalate-Mn(III) complex to serve a...

journal_title：Journal of inorganic biochemistry

authors： Sundaramoorthy M,Gold MH,Poulos TL

更新日期：2010-06-01 00:00:00

abstract：:The biochemically important anion, peroxynitrite, is commonly thought to have a cis-conformation which is stable. This is thought to have a cyclic structure, which blocks the formation of the trans-conformation. Furthermore, it is often suggested that the latter structure isomerises to the far more stable nitrate ion....

journal_title：Journal of inorganic biochemistry

authors： Symons MC

更新日期：2000-03-01 00:00:00

abstract：:The substitution of tetradentate bispidine ligands with rhodamine and cyanine dye molecules, coupled to an amine donor, forming an amide as potential fifth donor, is described. Bispidines are known to lead to very stable Cu(II) complexes, and the coordination to Cu(II) was expected to efficiently quench the fluorescen...

journal_title：Journal of inorganic biochemistry

authors： Brox D,Comba P,Herten DP,Kimmle E,Morgen M,Rühl CL,Rybina A,Stephan H,Storch G,Wadepohl H

更新日期：2015-07-01 00:00:00

abstract：:A new Ru(II) complex, [Ru(bpy)(2)(dhipH3)](ClO4)(2) (in which bpy=2,2'-bipyridine, dhipH(3)=3,4-dihydroxy-imidado[4,5-f][1,10]-phenanthroline), was synthesized and characterized, and the pH effect on the emission spectra of the complex was studied. The interaction of the complex with calf thymus DNA was investigated b...

journal_title：Journal of inorganic biochemistry

authors： Bai GY,Wang KZ,Duan ZM,Gao LH

更新日期：2004-06-01 00:00:00

abstract：:Aiming to investigate the use of tridentate ligands to develop new bireductively activated prodrugs, two N(2)O-donor ligands (HL1: [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine; and HL2: [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were used to synthesize new Co(III) complexes, 1 and 2. Both complexes were chara...

journal_title：Journal of inorganic biochemistry

authors： Souza ET,Castro LC,Castro FA,do Canto Visentin L,Pinheiro CB,Pereira MD,de Paula Machado S,Scarpellini M

更新日期：2009-10-01 00:00:00

abstract：:Aluminium (Al) has been measured in human breast tissue, and may be a contributory factor in breast cancer development. At the 10th Keele meeting, we reported that long-term exposure to Al could increase migratory properties of oestrogen-responsive MCF-7 human breast cancer cells suggesting a role for Al in the metast...

journal_title：Journal of inorganic biochemistry

authors： Bakir A,Darbre PD

更新日期：2015-11-01 00:00:00

abstract：:The pH dependence of the apparent affinity constants of perchlorate for cobalt(II)bovine carbonic anhydrase II has been measured by electronic absorption spectroscopy. The obtained data have been analyzed in terms of the ionization of two acidic groups of CoBCAII, and the affinity of perchlorate for the two water-cont...

journal_title：Journal of inorganic biochemistry

authors： Moratal JM,Martínez-Ferrer MJ,Donaire A,Aznar L

更新日期：1992-01-01 00:00:00

abstract：:It was shown that the treatment of a DNA fragment and a hepta-decanucleotide having a hairpin structure by Ru(2,2'-bipyridyl)3(3+) complex at 15 degrees C in 1 M NaCl for 10-60 min, and subsequent hydrolysis in 1 M piperidine at 95 degrees C led to the specific cleavage of the polynucleotide chain at guanosine residue...

journal_title：Journal of inorganic biochemistry

authors： Fedorova OS,Podust LM

更新日期：1988-11-01 00:00:00

abstract：:In this paper, Bi2S3 nanospheres with size of 212nm were prepared by a simple hydrothermal process. The selectively enhanced antibacterial effects of Bi2S3 nanospheres with three classes of ineffective antibiotics, β-lactam (cefuroxime, CXM; cefotaxime, CTX and piperacillin, PIP), quinolone (ciprofloxacin, CIP) and am...

journal_title：Journal of inorganic biochemistry

authors： Ma L,Wu J,Wang S,Yang H,Liang D,Lu Z

更新日期：2017-03-01 00:00:00

abstract：:Nearly all microbes require iron for growth. The low concentration of iron found in the ocean makes iron acquisition a particularly difficult task. In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake. We report herein the...

journal_title：Journal of inorganic biochemistry

authors： Gauglitz JM,Zhou H,Butler A

更新日期：2012-02-01 00:00:00

abstract：:The metallodrug chloridotetrakis(ibuprofenato)diruthenium(II,III) ([Ru2(Ibp)4Cl] or RuIbpCl (1), Ibp=carboxylate anion derived from the non-steroidal anti-inflammatory drug ibuprofen) has shown promising results in vitro and in vivo, which point to its potential as an inhibitor of glioma tumour growth in vivo. In orde...

journal_title：Journal of inorganic biochemistry

authors： Hanif-Ur-Rehman,Freitas TE,Gomes RN,Colquhoun A,de Oliveira Silva D

更新日期：2016-12-01 00:00:00

abstract：:The gallium(III) complex of a new tripodal 3-hydroxy-4-pyridinone (3,4-HP) chelator has been studied in terms of its physico-chemical and in vivo properties aimed at potential application as probe for nuclear imaging. In particular, based on spectrophotometric titrations, the hexa-coordinated (1:1) gallium complex app...

journal_title：Journal of inorganic biochemistry

authors： Chaves S,Mendonça AC,Marques SM,Prata MI,Santos AC,Martins AF,Geraldes CF,Santos MA

更新日期：2011-01-01 00:00:00

abstract：:The copper(II)-5-fluorosalicylic acid system was investigated in water and 50 v/v% water-methanol mixture by pH potentiometry combined with UV-vis spectrophotometry, and by the two-dimensional ESR simulation method, respectively. The data revealed that the stable paramagnetic mono- and bis(salicylato) copper(II) compl...

journal_title：Journal of inorganic biochemistry

authors： Szabó-Plánka T,Gyurcsik B,Nagy NV,Rockenbauer A,Sípos R,Sima J,Melník M

更新日期：2008-01-01 00:00:00

abstract：:The study aimed to develop simple assays to study aluminium-ligand interactions in natural/biological systems where equilibrium is rarely reached and thus where the initial seconds or hours of interactions are important. The immediate and non-equilibrium precipitation of aluminium hydroxide, in aqueous solution at neu...

journal_title：Journal of inorganic biochemistry

authors： Jugdaohsingh R,Salim N,McCrohan CR,White KN,Thompson RP,Powell JJ

更新日期：2001-11-01 00:00:00

abstract：:Gold nanorods (GNRs) are important platforms for biosensing and drug delivery. As for most nanomaterials, appropriate coatings such as polyethylene glycol (PEG) are needed to stabilize GNRs within biological fluids. We show here that the interactions of GNRs with proteins can be finely modulated through surface modifi...

journal_title：Journal of inorganic biochemistry

authors： Scaletti F,Feis A,Centi S,Pini R,Rotello VM,Messori L

更新日期：2015-09-01 00:00:00