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Secondary interactions involving zinc-bound ligands: roles in structural stabilization and macromolecular interactions.

Abstract：

:A large number of proteins contain bound zinc ions. These zinc ions are frequently coordinated by a combination of histidine and cysteine residues. In addition to atoms that coordinate directly to the zinc ions, these side chains have groups that can donate or accept hydrogen bonds from other groups. These secondary interactions can help stabilize the zinc-binding sites, can contribute to protein folding and stability, and, on occasion, can participate in interactions with other macromolecules. Five examples of these secondary interactions are discussed: carbonic anhydrase (where secondary interactions involving histidine residues stabilize the zinc-binding site thermodynamically and kinetically), retroviral nucleocapsid proteins and TRAF proteins (where cysteinate sulfur to peptide NH hydrogen bonds contribute to the structural relationships between adjacent domains), and nucleic acid binding proteins, Zif268 and TIS11 where secondary interactions participate in protein-nucleic acid interactions.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Namuswe F,Berg JM

doi

10.1016/j.jinorgbio.2011.10.018

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

146-9

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(11)00356-4

journal_volume

111

pub_type

杂志文章,评审

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