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Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Abstract：

:In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Percy ME,Kruck TP,Pogue AI,Lukiw WJ

doi

10.1016/j.jinorgbio.2011.08.001

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1505-12

issue

11

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(11)00214-5

journal_volume

105

pub_type

杂志文章,评审

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